Human Gene TCEAL4 (uc004ekn.3)
  Description: Homo sapiens transcription elongation factor A (SII)-like 4 (TCEAL4), transcript variant 4, mRNA.
RefSeq Summary (NM_001006937): This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015].
Transcript (Including UTRs)
   Position: hg19 chrX:102,840,419-102,842,655 Size: 2,237 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chrX:102,841,604-102,842,251 Size: 648 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:102,840,419-102,842,655)mRNA (may differ from genome)Protein (215 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TCAL4_HUMAN
DESCRIPTION: RecName: Full=Transcription elongation factor A protein-like 4; Short=TCEA-like protein 4; AltName: Full=Transcription elongation factor S-II protein-like 4;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the TFS-II family. TFA subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 291.31 RPKM in Ovary
Total median expression: 3797.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -92.40229-0.403 Picture PostScript Text
3' UTR -83.30404-0.206 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021156 - TF_A-like/BEX-like
IPR010370 - TFA

Pfam Domains:
PF04538 - Brain expressed X-linked like family

ModBase Predicted Comparative 3D Structure on Q96EI5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0050699 WW domain binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AF314542 - Homo sapiens B lymphocyte activation-related protein mRNA, complete cds.
AL833640 - Homo sapiens mRNA; cDNA DKFZp686M0279 (from clone DKFZp686M0279).
AK024827 - Homo sapiens cDNA: FLJ21174 fis, clone CAS11066.
AK225117 - Homo sapiens mRNA for transcription elongation factor A-like 4 variant, clone: CAS11066.
Z36792 - H.sapiens (xs141) mRNA, 400bp.
AK093021 - Homo sapiens cDNA FLJ35702 fis, clone SPLEN2020034.
AX747862 - Sequence 1387 from Patent EP1308459.
AF271783 - Homo sapiens NPD017 mRNA, complete cds.
AY885169 - Homo sapiens transcription elongation factor A (SII)-like 4 variant 1 mRNA, complete cds, alternatively spliced.
BC012296 - Homo sapiens transcription elongation factor A (SII)-like 4, mRNA (cDNA clone MGC:5372 IMAGE:3445403), complete cds.
CU680276 - Synthetic construct Homo sapiens gateway clone IMAGE:100016788 5' read TCEAL4 mRNA.
HQ447129 - Synthetic construct Homo sapiens clone IMAGE:100070417; CCSB002411_02 transcription elongation factor A (SII)-like 4 (TCEAL4) gene, encodes complete protein.
KJ899592 - Synthetic construct Homo sapiens clone ccsbBroadEn_08986 TCEAL4 gene, encodes complete protein.
GQ891301 - Homo sapiens clone HEL-S-24a epididymis secretory sperm binding protein mRNA, complete cds.
JD158616 - Sequence 139640 from Patent EP1572962.
JD363347 - Sequence 344371 from Patent EP1572962.
JD374921 - Sequence 355945 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001006937, NPD017, NP_079139, Q8WY12, Q96EI5, Q9H2H1, Q9H775, TCAL4_HUMAN
UCSC ID: uc004ekn.3
RefSeq Accession: NM_001006937
Protein: Q96EI5 (aka TCAL4_HUMAN)
CCDS: CCDS14510.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001006937.1
exon count: 3CDS single in 3' UTR: no RNA size: 1289
ORF size: 648CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1493.00frame shift in genome: no % Coverage: 99.38
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.