Description: Homo sapiens ring finger protein 128, E3 ubiquitin protein ligase (RNF128), transcript variant 1, mRNA. RefSeq Summary (NM_194463): The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chrX:105,969,894-106,040,246 Size: 70,353 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chrX:105,970,144-106,038,943 Size: 68,800 Coding Exon Count: 7
ID:RN128_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase RNF128; EC=6.3.2.-; AltName: Full=Gene related to anergy in lymphocytes protein; AltName: Full=RING finger protein 128; Flags: Precursor; FUNCTION: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural- inducing signals (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Endomembrane system; Single-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). INDUCTION: Induced under anergic conditions. Up-regulated during T-cell anergy induction following signaling through the T-cell antigen receptor. DOMAIN: Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain. PTM: Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination. SIMILARITY: Contains 1 PA (protease associated) domain. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAB15682.1; Type=Frameshift; Positions=291;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TEB7
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0016567 protein ubiquitination GO:0016579 protein deubiquitination GO:0031647 regulation of protein stability GO:0042036 negative regulation of cytokine biosynthetic process GO:0061462 protein localization to lysosome GO:1904352 positive regulation of protein catabolic process in the vacuole
US Server
