ID:UCP5_HUMAN DESCRIPTION: RecName: Full=Brain mitochondrial carrier protein 1; Short=BMCP-1; AltName: Full=Mitochondrial uncoupling protein 5; Short=UCP 5; AltName: Full=Solute carrier family 25 member 14; FUNCTION: Participates in the mitochondrial proton leak measured in brain mitochondria. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Mainly expressed in brain. Some expression in testis and pituitary. SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SLC25A14 CDC HuGE Published Literature: SLC25A14 Positive Disease Associations: schizophrenia Related Studies:
schizophrenia Yasuno, K. et al. 2006, Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia, Am J Med Genet B Neuropsychiatr Genet 2006.
[PubMed 17066476]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95258
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK304649 - Homo sapiens cDNA FLJ54254 complete cds, highly similar to Brain mitochondrial carrier protein 1. AK296155 - Homo sapiens cDNA FLJ60600 complete cds, highly similar to Brain mitochondrial carrier protein 1. AF078544 - Homo sapiens brain mitochondrial carrier protein-1 (BMCP1) mRNA, nuclear gene encoding mitochondrial protein, complete cds. BC119667 - Homo sapiens solute carrier family 25 (mitochondrial carrier, brain), member 14, mRNA (cDNA clone MGC:149544 IMAGE:40116118), complete cds. BC119666 - Homo sapiens solute carrier family 25 (mitochondrial carrier, brain), member 14, mRNA (cDNA clone MGC:149543 IMAGE:40116117), complete cds. KJ892669 - Synthetic construct Homo sapiens clone ccsbBroadEn_02063 SLC25A14 gene, encodes complete protein. AF155809 - Homo sapiens mitochondrial uncoupling protein 5 long form mRNA, complete cds; nuclear gene for mitochondrial product. AF155810 - Homo sapiens mitochondrial uncoupling protein 5 short form with insertion mRNA, complete cds; nuclear gene for mitochondrial product. AF155811 - Homo sapiens mitochondrial uncoupling protein 5 short form mRNA, complete cds; nuclear gene for mitochondrial product. AY358099 - Homo sapiens clone DNA80562 UCP5 (UNQ791) mRNA, complete cds. AK297499 - Homo sapiens cDNA FLJ60702 complete cds, highly similar to Brain mitochondrial carrier protein 1. AK309433 - Homo sapiens cDNA, FLJ99474. JD418795 - Sequence 399819 from Patent EP1572962. JD055781 - Sequence 36805 from Patent EP1572962. JD165153 - Sequence 146177 from Patent EP1572962. JD416887 - Sequence 397911 from Patent EP1572962. JD148959 - Sequence 129983 from Patent EP1572962. JD096389 - Sequence 77413 from Patent EP1572962. JD448070 - Sequence 429094 from Patent EP1572962. JD038137 - Sequence 19161 from Patent EP1572962. JD269859 - Sequence 250883 from Patent EP1572962. JD359490 - Sequence 340514 from Patent EP1572962. JD042515 - Sequence 23539 from Patent EP1572962. JD549362 - Sequence 530386 from Patent EP1572962. JD206594 - Sequence 187618 from Patent EP1572962. JD170336 - Sequence 151360 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95258 (Reactome details) participates in the following event(s):
R-HSA-166220 FA anion diffuses laterally to UCP R-HSA-166387 The FA anion diffuses away laterally from UCP R-HSA-166214 FA anion flip-flops to the opposite surface R-HSA-170026 Protons are translocated from the intermembrane space to the matrix R-HSA-167826 The fatty acid cycling model R-HSA-166187 Mitochondrial Uncoupling Proteins R-HSA-167827 The proton buffering model R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism