Human Gene SLC25A14 (uc004evp.1)
  Description: Homo sapiens solute carrier family 25 (mitochondrial carrier, brain), member 14 (SLC25A14), nuclear gene encoding mitochondrial protein, transcript variant long, mRNA.
Transcript (Including UTRs)
   Position: hg19 chrX:129,474,047-129,507,335 Size: 33,289 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chrX:129,474,253-129,506,924 Size: 32,672 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:129,474,047-129,507,335)mRNA (may differ from genome)Protein (325 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
ReactomeTreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: UCP5_HUMAN
DESCRIPTION: RecName: Full=Brain mitochondrial carrier protein 1; Short=BMCP-1; AltName: Full=Mitochondrial uncoupling protein 5; Short=UCP 5; AltName: Full=Solute carrier family 25 member 14;
FUNCTION: Participates in the mitochondrial proton leak measured in brain mitochondria.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Mainly expressed in brain. Some expression in testis and pituitary.
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SLC25A14
CDC HuGE Published Literature: SLC25A14
Positive Disease Associations: schizophrenia
Related Studies:
  1. schizophrenia
    Yasuno, K. et al. 2006, Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia, Am J Med Genet B Neuropsychiatr Genet 2006. [PubMed 17066476]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.02 RPKM in Pituitary
Total median expression: 188.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -66.82206-0.324 Picture PostScript Text
3' UTR -115.40411-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002030 - Mit_uncoupling
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on O95258
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0009060 aerobic respiration
GO:0055085 transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005743 mitochondrial inner membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane


-  Descriptions from all associated GenBank mRNAs
  AK304649 - Homo sapiens cDNA FLJ54254 complete cds, highly similar to Brain mitochondrial carrier protein 1.
AK296155 - Homo sapiens cDNA FLJ60600 complete cds, highly similar to Brain mitochondrial carrier protein 1.
AF078544 - Homo sapiens brain mitochondrial carrier protein-1 (BMCP1) mRNA, nuclear gene encoding mitochondrial protein, complete cds.
BC119667 - Homo sapiens solute carrier family 25 (mitochondrial carrier, brain), member 14, mRNA (cDNA clone MGC:149544 IMAGE:40116118), complete cds.
BC119666 - Homo sapiens solute carrier family 25 (mitochondrial carrier, brain), member 14, mRNA (cDNA clone MGC:149543 IMAGE:40116117), complete cds.
KJ892669 - Synthetic construct Homo sapiens clone ccsbBroadEn_02063 SLC25A14 gene, encodes complete protein.
AF155809 - Homo sapiens mitochondrial uncoupling protein 5 long form mRNA, complete cds; nuclear gene for mitochondrial product.
AF155810 - Homo sapiens mitochondrial uncoupling protein 5 short form with insertion mRNA, complete cds; nuclear gene for mitochondrial product.
AF155811 - Homo sapiens mitochondrial uncoupling protein 5 short form mRNA, complete cds; nuclear gene for mitochondrial product.
AY358099 - Homo sapiens clone DNA80562 UCP5 (UNQ791) mRNA, complete cds.
AK297499 - Homo sapiens cDNA FLJ60702 complete cds, highly similar to Brain mitochondrial carrier protein 1.
AK309433 - Homo sapiens cDNA, FLJ99474.
JD418795 - Sequence 399819 from Patent EP1572962.
JD055781 - Sequence 36805 from Patent EP1572962.
JD165153 - Sequence 146177 from Patent EP1572962.
JD416887 - Sequence 397911 from Patent EP1572962.
JD148959 - Sequence 129983 from Patent EP1572962.
JD096389 - Sequence 77413 from Patent EP1572962.
JD448070 - Sequence 429094 from Patent EP1572962.
JD038137 - Sequence 19161 from Patent EP1572962.
JD269859 - Sequence 250883 from Patent EP1572962.
JD359490 - Sequence 340514 from Patent EP1572962.
JD042515 - Sequence 23539 from Patent EP1572962.
JD549362 - Sequence 530386 from Patent EP1572962.
JD206594 - Sequence 187618 from Patent EP1572962.
JD170336 - Sequence 151360 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O95258 (Reactome details) participates in the following event(s):

R-HSA-166220 FA anion diffuses laterally to UCP
R-HSA-166387 The FA anion diffuses away laterally from UCP
R-HSA-166214 FA anion flip-flops to the opposite surface
R-HSA-170026 Protons are translocated from the intermembrane space to the matrix
R-HSA-167826 The fatty acid cycling model
R-HSA-166187 Mitochondrial Uncoupling Proteins
R-HSA-167827 The proton buffering model
R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: BMCP1, D3DTG2, NM_003951, NP_003942, O95258, Q0VDH7, Q9HC60, Q9HC61, UCP5, UCP5_HUMAN, UNQ791/PRO1682
UCSC ID: uc004evp.1
RefSeq Accession: NM_003951
Protein: O95258 (aka UCP5_HUMAN)
CCDS: CCDS14623.1, CCDS14624.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_003951.2
exon count: 10CDS single in 3' UTR: no RNA size: 1601
ORF size: 978CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2156.00frame shift in genome: no % Coverage: 99.63
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 34# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.