Description: Homo sapiens melanoma antigen family A, 10 (MAGEA10), transcript variant 1, mRNA. RefSeq Summary (NM_001011543): This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]. Transcript (Including UTRs) Position: hg19 chrX:151,301,783-151,307,050 Size: 5,268 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chrX:151,302,983-151,304,092 Size: 1,110 Coding Exon Count: 1
ID:MAGAA_HUMAN DESCRIPTION: RecName: Full=Melanoma-associated antigen 10; AltName: Full=Cancer/testis antigen 1.10; Short=CT1.10; AltName: Full=MAGE-10 antigen; FUNCTION: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. TISSUE SPECIFICITY: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. SIMILARITY: Contains 1 MAGE domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01454 - MAGE family PF12440 - Melanoma associated antigen family N terminal
ModBase Predicted Comparative 3D Structure on P43363
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
