Description: Homo sapiens POU class 2 homeobox 1 (POU2F1), transcript variant 3, mRNA. RefSeq Summary (NM_001198786): The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]. Transcript (Including UTRs) Position: hg19 chr1:167,368,423-167,381,541 Size: 13,119 Total Exon Count: 2 Strand: +
Alzheimer's Disease Taguchi, K. et al. 2005, Identification of hippocampus-related candidate genes for Alzheimer's disease., Annals of neurology. 2005 Apr;57(4):585-8.
[PubMed 15786443]
Our results suggest that POU2F1 is a candidate gene for AD.
plasma levels of liver enzymes Yuan ,et al. 2008, Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes, American journal of human genetics 2008 83- 4 : 520-8.
[PubMed 18940312]
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
LF205434 - JP 2014500723-A/12937: Polycomb-Associated Non-Coding RNAs. AK308004 - Homo sapiens cDNA, FLJ97952. AK303201 - Homo sapiens cDNA FLJ57693 complete cds, highly similar to POU domain, class 2, transcription factor 1. AK091438 - Homo sapiens cDNA FLJ34119 fis, clone FCBBF3009464, highly similar to POU domain, class 2, transcription factor 1. BC052274 - Homo sapiens POU class 2 homeobox 1, mRNA (cDNA clone MGC:59844 IMAGE:4622256), complete cds. X13403 - Human mRNA for octamer-binding protein Oct-1. KT438684 - Homo sapiens POU class 2 homeobox 1 (POU2F1) mRNA, complete cds. AY113189 - Homo sapiens OCT-1 protein (POU2F1) mRNA, complete cds. BC001664 - Homo sapiens POU class 2 homeobox 1, mRNA (cDNA clone MGC:1676 IMAGE:2966289), complete cds. BC003571 - Homo sapiens POU class 2 homeobox 1, mRNA (cDNA clone MGC:2114 IMAGE:3544378), complete cds. MH025885 - Homo sapiens POU class 2 homeobox 1 isoform Oct-1R (POU2F1) mRNA, complete cds, alternatively spliced. KJ901652 - Synthetic construct Homo sapiens clone ccsbBroadEn_11046 POU2F1 gene, encodes complete protein. AB463190 - Synthetic construct DNA, clone: pF1KB9569, Homo sapiens POU2F1 gene for POU class 2 homeobox 1, without stop codon, in Flexi system. BC007388 - Homo sapiens POU class 2 homeobox 1, mRNA (cDNA clone IMAGE:3830953), partial cds. S66902 - oct-1B=POU homeodomain protein {alternatively spliced} [human, NTera 2D1, mRNA Partial, 89 nt]. MA441011 - JP 2018138019-A/12937: Polycomb-Associated Non-Coding RNAs.