Human Gene POU2F1 (uc009wvg.1)
  Description: Homo sapiens POU class 2 homeobox 1 (POU2F1), transcript variant 3, mRNA.
RefSeq Summary (NM_001198786): The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010].
Transcript (Including UTRs)
   Position: hg19 chr1:167,368,423-167,381,541 Size: 13,119 Total Exon Count: 2 Strand: +


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:167,368,423-167,381,541)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerH-INVHGNCLynxMalacards
PubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): POU2F1
CDC HuGE Published Literature: POU2F1
Positive Disease Associations: Alzheimer's Disease , Erythrocyte Count , plasma levels of liver enzymes
Related Studies:
  1. Alzheimer's Disease
    Taguchi, K. et al. 2005, Identification of hippocampus-related candidate genes for Alzheimer's disease., Annals of neurology. 2005 Apr;57(4):585-8. [PubMed 15786443]
    Our results suggest that POU2F1 is a candidate gene for AD.
  2. Erythrocyte Count
    , , . [PubMed 0]
  3. plasma levels of liver enzymes
    Yuan ,et al. 2008, Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes, American journal of human genetics 2008 83- 4 : 520-8. [PubMed 18940312]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: POU2F1
Diseases sorted by gene-association score: herpes simplex (9), primary amebic meningoencephalitis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.75 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 125.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF205434 - JP 2014500723-A/12937: Polycomb-Associated Non-Coding RNAs.
AK308004 - Homo sapiens cDNA, FLJ97952.
AK303201 - Homo sapiens cDNA FLJ57693 complete cds, highly similar to POU domain, class 2, transcription factor 1.
AK091438 - Homo sapiens cDNA FLJ34119 fis, clone FCBBF3009464, highly similar to POU domain, class 2, transcription factor 1.
BC052274 - Homo sapiens POU class 2 homeobox 1, mRNA (cDNA clone MGC:59844 IMAGE:4622256), complete cds.
X13403 - Human mRNA for octamer-binding protein Oct-1.
KT438684 - Homo sapiens POU class 2 homeobox 1 (POU2F1) mRNA, complete cds.
AY113189 - Homo sapiens OCT-1 protein (POU2F1) mRNA, complete cds.
BC001664 - Homo sapiens POU class 2 homeobox 1, mRNA (cDNA clone MGC:1676 IMAGE:2966289), complete cds.
BC003571 - Homo sapiens POU class 2 homeobox 1, mRNA (cDNA clone MGC:2114 IMAGE:3544378), complete cds.
MH025885 - Homo sapiens POU class 2 homeobox 1 isoform Oct-1R (POU2F1) mRNA, complete cds, alternatively spliced.
KJ901652 - Synthetic construct Homo sapiens clone ccsbBroadEn_11046 POU2F1 gene, encodes complete protein.
AB463190 - Synthetic construct DNA, clone: pF1KB9569, Homo sapiens POU2F1 gene for POU class 2 homeobox 1, without stop codon, in Flexi system.
BC007388 - Homo sapiens POU class 2 homeobox 1, mRNA (cDNA clone IMAGE:3830953), partial cds.
S66902 - oct-1B=POU homeodomain protein {alternatively spliced} [human, NTera 2D1, mRNA Partial, 89 nt].
MA441011 - JP 2018138019-A/12937: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: S66902
UCSC ID: uc009wvg.1
RefSeq Accession: NM_001198786

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: S66902.1
exon count: 2CDS single in 3' UTR: no RNA size: 89
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 578.00frame shift in genome: no % Coverage: 100.00
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.