Human Gene XPR1 (uc009wxn.3)
Description: Homo sapiens xenotropic and polytropic retrovirus receptor 1 (XPR1), transcript variant 2, mRNA.
RefSeq Summary (NM_001135669): The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016].
Transcript (Including UTRs)
Position: hg19 chr1:180,601,146-180,859,415 Size: 258,270 Total Exon Count: 14 Strand: +
Coding Region
Position: hg19 chr1:180,601,338-180,853,202 Size: 251,865 Coding Exon Count: 14
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): XPR1
CDC HuGE Published Literature: XPR1
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF03105 - SPX domain
PF03124 - EXS family
ModBase Predicted Comparative 3D Structure on Q9UBH6-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
BC028576 - Homo sapiens cDNA clone IMAGE:4827651, containing frame-shift errors.AK309750 - Homo sapiens cDNA, FLJ99791.BC041142 - Homo sapiens xenotropic and polytropic retrovirus receptor, mRNA (cDNA clone MGC:47521 IMAGE:5582839), complete cds.AF089744 - Homo sapiens xenotropic and polytropic murine leukemia virus receptor (X3) mRNA, complete cds.AF099082 - Homo sapiens xenotropic and polytropic murine retrovirus receptor (XPR1) mRNA, complete cds.CU691970 - Synthetic construct Homo sapiens gateway clone IMAGE:100021210 5' read XPR1 mRNA.KJ892715 - Synthetic construct Homo sapiens clone ccsbBroadEn_02109 XPR1 gene, encodes complete protein.AF115389 - Homo sapiens SYG1 protein (SYG1) mRNA, complete cds.JD309134 - Sequence 290158 from Patent EP1572962.JD523711 - Sequence 504735 from Patent EP1572962.AL133058 - Homo sapiens mRNA; cDNA DKFZp434K0615 (from clone DKFZp434K0615).AL137583 - Homo sapiens mRNA; cDNA DKFZp434F1310 (from clone DKFZp434F1310).AK074789 - Homo sapiens cDNA FLJ90308 fis, clone NT2RP2000818, highly similar to Homo sapiens xenotropic and polytropic murine leukemia virus receptor (X3) mRNA.JD555378 - Sequence 536402 from Patent EP1572962.JD555576 - Sequence 536600 from Patent EP1572962.JD373495 - Sequence 354519 from Patent EP1572962.JD268055 - Sequence 249079 from Patent EP1572962.JD409396 - Sequence 390420 from Patent EP1572962.JD126073 - Sequence 107097 from Patent EP1572962.LF205405 - JP 2014500723-A/12908: Polycomb-Associated Non-Coding RNAs.LF320147 - JP 2014500723-A/127650: Polycomb-Associated Non-Coding RNAs.JD339528 - Sequence 320552 from Patent EP1572962.LF320146 - JP 2014500723-A/127649: Polycomb-Associated Non-Coding RNAs.JD323355 - Sequence 304379 from Patent EP1572962.JD171445 - Sequence 152469 from Patent EP1572962.JD062184 - Sequence 43208 from Patent EP1572962.JD298816 - Sequence 279840 from Patent EP1572962.JD304062 - Sequence 285086 from Patent EP1572962.JD275101 - Sequence 256125 from Patent EP1572962.JD566172 - Sequence 547196 from Patent EP1572962.JD297111 - Sequence 278135 from Patent EP1572962.JD503939 - Sequence 484963 from Patent EP1572962.JD298772 - Sequence 279796 from Patent EP1572962.JD323812 - Sequence 304836 from Patent EP1572962.LF320145 - JP 2014500723-A/127648: Polycomb-Associated Non-Coding RNAs.LF320144 - JP 2014500723-A/127647: Polycomb-Associated Non-Coding RNAs.JD530164 - Sequence 511188 from Patent EP1572962.AK056306 - Homo sapiens cDNA FLJ31744 fis, clone NT2RI2007277.JD229742 - Sequence 210766 from Patent EP1572962.JD536187 - Sequence 517211 from Patent EP1572962.JD376050 - Sequence 357074 from Patent EP1572962.JD542829 - Sequence 523853 from Patent EP1572962.JD542830 - Sequence 523854 from Patent EP1572962.JD542831 - Sequence 523855 from Patent EP1572962.JD542832 - Sequence 523856 from Patent EP1572962.JD344147 - Sequence 325171 from Patent EP1572962.JD498424 - Sequence 479448 from Patent EP1572962.AK023131 - Homo sapiens cDNA FLJ13069 fis, clone NT2RP3001752.LF320143 - JP 2014500723-A/127646: Polycomb-Associated Non-Coding RNAs.LF320142 - JP 2014500723-A/127645: Polycomb-Associated Non-Coding RNAs.AB075495 - Homo sapiens neuroblastoma cDNA, clone:Nbla00181, full insert sequence.LF320141 - JP 2014500723-A/127644: Polycomb-Associated Non-Coding RNAs.U79279 - Human clone 23774 mRNA sequence.LF320140 - JP 2014500723-A/127643: Polycomb-Associated Non-Coding RNAs.MA440982 - JP 2018138019-A/12908: Polycomb-Associated Non-Coding RNAs.MA555724 - JP 2018138019-A/127650: Polycomb-Associated Non-Coding RNAs.MA555723 - JP 2018138019-A/127649: Polycomb-Associated Non-Coding RNAs.MA555722 - JP 2018138019-A/127648: Polycomb-Associated Non-Coding RNAs.MA555721 - JP 2018138019-A/127647: Polycomb-Associated Non-Coding RNAs.MA555720 - JP 2018138019-A/127646: Polycomb-Associated Non-Coding RNAs.MA555719 - JP 2018138019-A/127645: Polycomb-Associated Non-Coding RNAs.MA555718 - JP 2018138019-A/127644: Polycomb-Associated Non-Coding RNAs.MA555717 - JP 2018138019-A/127643: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
GeneReviews for This Gene
GeneReviews article(s) related to gene XPR1:bgc (Primary Familial Brain Calcification)
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001135669.1
exon count:
14 CDS single in 3' UTR:
no
RNA size:
8305
ORF size:
1896 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
3860.00 frame shift in genome:
no
% Coverage:
99.95
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.