Human Gene ANKRD26 (uc009xku.1)
Description: Homo sapiens ankyrin repeat domain 26 (ANKRD26), transcript variant 1, mRNA.
RefSeq Summary (NM_014915): This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Transcript (Including UTRs)
Position: hg19 chr10:27,293,045-27,389,427 Size: 96,383 Total Exon Count: 34 Strand: -
Coding Region
Position: hg19 chr10:27,294,519-27,389,255 Size: 94,737 Coding Exon Count: 34
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ANKRD26
CDC HuGE Published Literature: ANKRD26
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00023 - Ankyrin repeat
PF12001 - Domain of unknown function (DUF3496)
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)
PF14915 - CCDC144C protein coiled-coil region
SCOP Domains: 48403 - Ankyrin repeat
ModBase Predicted Comparative 3D Structure on Q9UPS8-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Descriptions from all associated GenBank mRNAs
KJ902241 - Synthetic construct Homo sapiens clone ccsbBroadEn_11635 ANKRD26 gene, encodes complete protein.BC110646 - Homo sapiens ankyrin repeat domain 26, mRNA (cDNA clone IMAGE:4385560), partial cds.AL137351 - Homo sapiens mRNA; cDNA DKFZp434E0825 (from clone DKFZp434E0825).LF384178 - JP 2014500723-A/191681: Polycomb-Associated Non-Coding RNAs.LF365352 - JP 2014500723-A/172855: Polycomb-Associated Non-Coding RNAs.AL162063 - Homo sapiens mRNA; cDNA DKFZp762D185 (from clone DKFZp762D185).AK128577 - Homo sapiens cDNA FLJ46736 fis, clone TRACH3020769, weakly similar to Myosin heavy chain, nonmuscle type B.AB028997 - Homo sapiens KIAA1074 mRNA for KIAA1074 protein.JD298300 - Sequence 279324 from Patent EP1572962.BC130453 - Homo sapiens ankyrin repeat domain 26, mRNA (cDNA clone MGC:163325 IMAGE:40146484), complete cds.AB384103 - Synthetic construct DNA, clone: pF1KSDA1074, Homo sapiens ANKRD26 gene for ankyrin repeat domain-containing protein 26, complete cds, without stop codon, in Flexi system.LF365354 - JP 2014500723-A/172857: Polycomb-Associated Non-Coding RNAs.LF365355 - JP 2014500723-A/172858: Polycomb-Associated Non-Coding RNAs.LF365356 - JP 2014500723-A/172859: Polycomb-Associated Non-Coding RNAs.LF365357 - JP 2014500723-A/172860: Polycomb-Associated Non-Coding RNAs.LF365358 - JP 2014500723-A/172861: Polycomb-Associated Non-Coding RNAs.LF365359 - JP 2014500723-A/172862: Polycomb-Associated Non-Coding RNAs.LF365360 - JP 2014500723-A/172863: Polycomb-Associated Non-Coding RNAs.LF365361 - JP 2014500723-A/172864: Polycomb-Associated Non-Coding RNAs.LF365362 - JP 2014500723-A/172865: Polycomb-Associated Non-Coding RNAs.LF365363 - JP 2014500723-A/172866: Polycomb-Associated Non-Coding RNAs.LF365364 - JP 2014500723-A/172867: Polycomb-Associated Non-Coding RNAs.LF365365 - JP 2014500723-A/172868: Polycomb-Associated Non-Coding RNAs.LF365366 - JP 2014500723-A/172869: Polycomb-Associated Non-Coding RNAs.LF365367 - JP 2014500723-A/172870: Polycomb-Associated Non-Coding RNAs.LF365368 - JP 2014500723-A/172871: Polycomb-Associated Non-Coding RNAs.LF365370 - JP 2014500723-A/172873: Polycomb-Associated Non-Coding RNAs.LF365371 - JP 2014500723-A/172874: Polycomb-Associated Non-Coding RNAs.DQ577672 - Homo sapiens piRNA piR-45784, complete sequence.LF365374 - JP 2014500723-A/172877: Polycomb-Associated Non-Coding RNAs.AK001137 - Homo sapiens cDNA FLJ10275 fis, clone HEMBB1001175, weakly similar to ANKYRIN.LF365375 - JP 2014500723-A/172878: Polycomb-Associated Non-Coding RNAs.LF365376 - JP 2014500723-A/172879: Polycomb-Associated Non-Coding RNAs.LF365378 - JP 2014500723-A/172881: Polycomb-Associated Non-Coding RNAs.KY966267 - Homo sapiens cell line 95T1000 GNS/ANKRD26/NCKAP1L fusion mRNA, partial sequence.DQ586806 - Homo sapiens piRNA piR-53918, complete sequence.LF365381 - JP 2014500723-A/172884: Polycomb-Associated Non-Coding RNAs.LF365383 - JP 2014500723-A/172886: Polycomb-Associated Non-Coding RNAs.MA619755 - JP 2018138019-A/191681: Polycomb-Associated Non-Coding RNAs.MA600929 - JP 2018138019-A/172855: Polycomb-Associated Non-Coding RNAs.MA600931 - JP 2018138019-A/172857: Polycomb-Associated Non-Coding RNAs.MA600932 - JP 2018138019-A/172858: Polycomb-Associated Non-Coding RNAs.MA600933 - JP 2018138019-A/172859: Polycomb-Associated Non-Coding RNAs.MA600934 - JP 2018138019-A/172860: Polycomb-Associated Non-Coding RNAs.MA600935 - JP 2018138019-A/172861: Polycomb-Associated Non-Coding RNAs.MA600936 - JP 2018138019-A/172862: Polycomb-Associated Non-Coding RNAs.MA600937 - JP 2018138019-A/172863: Polycomb-Associated Non-Coding RNAs.MA600938 - JP 2018138019-A/172864: Polycomb-Associated Non-Coding RNAs.MA600939 - JP 2018138019-A/172865: Polycomb-Associated Non-Coding RNAs.MA600940 - JP 2018138019-A/172866: Polycomb-Associated Non-Coding RNAs.MA600941 - JP 2018138019-A/172867: Polycomb-Associated Non-Coding RNAs.MA600942 - JP 2018138019-A/172868: Polycomb-Associated Non-Coding RNAs.MA600943 - JP 2018138019-A/172869: Polycomb-Associated Non-Coding RNAs.MA600944 - JP 2018138019-A/172870: Polycomb-Associated Non-Coding RNAs.MA600945 - JP 2018138019-A/172871: Polycomb-Associated Non-Coding RNAs.MA600947 - JP 2018138019-A/172873: Polycomb-Associated Non-Coding RNAs.MA600948 - JP 2018138019-A/172874: Polycomb-Associated Non-Coding RNAs.MA600951 - JP 2018138019-A/172877: Polycomb-Associated Non-Coding RNAs.MA600952 - JP 2018138019-A/172878: Polycomb-Associated Non-Coding RNAs.MA600953 - JP 2018138019-A/172879: Polycomb-Associated Non-Coding RNAs.MA600955 - JP 2018138019-A/172881: Polycomb-Associated Non-Coding RNAs.MA600958 - JP 2018138019-A/172884: Polycomb-Associated Non-Coding RNAs.MA600960 - JP 2018138019-A/172886: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: KIAA1074, NM_014915, NP_055730, Q9UPS8-3UCSC ID: uc009xku.1RefSeq Accession: NM_014915
Protein: Q9UPS8-3 , splice isoform of Q9UPS8
CCDS: CCDS41499.1
GeneReviews for This Gene
GeneReviews article(s) related to gene ANKRD26:ankrd26 (ANKRD26-Related Thrombocytopenia)
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_014915.2
exon count:
34 CDS single in 3' UTR:
no
RNA size:
6816
ORF size:
5133 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
8127.00 frame shift in genome:
no
% Coverage:
99.46
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.