Description: Homo sapiens catalase (CAT), mRNA. RefSeq Summary (NM_001752): This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]. Transcript (Including UTRs) Position: hg19 chr11:34,470,739-34,485,782 Size: 15,044 Total Exon Count: 10 Strand: +
blood catalase levels Forsberg, L. et al. 2001, A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels, Free radical biology & medicine. 2001 Mar;30(5):500-5.
[PubMed 11182520]
we report here the first common (allele frequency in a Swedish population, 28%) genetic variant in a fundamental oxidative stress protection gene with a defined phenotype.
bone density Oh, B. et al. 2007, Associations of catalase gene polymorphisms with bone mineral density and bone turnover markers in postmenopausal women, J Med Genet 2007 44(1) e62.
[PubMed 17209132]
These findings indicate that the +22348C-->T polymorphism and HT4 of CAT may be useful genetic markers for bone metabolism.
catalase activity Ahn, J. et al. 2006, Associations between Catalase Phenotype and Genotype, Cancer Epidemiol Biomarkers Prev 2006 15(6) 1217-22.
[PubMed 16775184]
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
KJ890831 - Synthetic construct Homo sapiens clone ccsbBroadEn_00225 CAT gene, encodes complete protein. KR711567 - Synthetic construct Homo sapiens clone CCSBHm_00026863 CAT (CAT) mRNA, encodes complete protein. KR711568 - Synthetic construct Homo sapiens clone CCSBHm_00026864 CAT (CAT) mRNA, encodes complete protein. KR711569 - Synthetic construct Homo sapiens clone CCSBHm_00026865 CAT (CAT) mRNA, encodes complete protein. LF205797 - JP 2014500723-A/13300: Polycomb-Associated Non-Coding RNAs. AK291585 - Homo sapiens cDNA FLJ78138 complete cds, highly similar to Homo sapiens catalase (CAT), mRNA. BC110398 - Homo sapiens catalase, mRNA (cDNA clone MGC:117400 IMAGE:5551309), complete cds. AK315350 - Homo sapiens cDNA, FLJ96395, highly similar to Homo sapiens catalase (CAT), mRNA. X04076 - Human kidney mRNA for catalase. BC112217 - Homo sapiens catalase, mRNA (cDNA clone MGC:138422 IMAGE:8327685), complete cds. BC112219 - Homo sapiens catalase, mRNA (cDNA clone MGC:138424 IMAGE:8327687), complete cds. GQ891493 - Homo sapiens clone HEL-S-214 epididymis secretory sperm binding protein mRNA, complete cds. AB587573 - Synthetic construct DNA, clone: pF1KE1962, Homo sapiens CAT gene for catalase, without stop codon, in Flexi system. E01497 - cDNA encoding human catalase. HQ258304 - Synthetic construct Homo sapiens clone IMAGE:100072613 catalase (CAT) gene, encodes complete protein. AY028632 - Homo sapiens catalase (CAT) mRNA, complete cds. AK301577 - Homo sapiens cDNA FLJ60361 complete cds, highly similar to Catalase (EC 1.11.1.6). AK310184 - Homo sapiens cDNA, FLJ17226. MA441374 - JP 2018138019-A/13300: Polycomb-Associated Non-Coding RNAs. JD026241 - Sequence 7265 from Patent EP1572962. JD019536 - Sequence 560 from Patent EP1572962. JD030140 - Sequence 11164 from Patent EP1572962. LF348339 - JP 2014500723-A/155842: Polycomb-Associated Non-Coding RNAs. LF348337 - JP 2014500723-A/155840: Polycomb-Associated Non-Coding RNAs. BC027300 - Homo sapiens, Similar to catalase, clone IMAGE:3924219, mRNA, partial cds. CS121466 - Sequence 1 from Patent WO2005056048. LF348330 - JP 2014500723-A/155833: Polycomb-Associated Non-Coding RNAs. MA583916 - JP 2018138019-A/155842: Polycomb-Associated Non-Coding RNAs. MA583914 - JP 2018138019-A/155840: Polycomb-Associated Non-Coding RNAs. MA583907 - JP 2018138019-A/155833: Polycomb-Associated Non-Coding RNAs.