Human Gene RDX (uc009yxx.1)
  Description: Homo sapiens radixin (RDX), transcript variant 2, mRNA.
RefSeq Summary (NM_001260493): Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
Transcript (Including UTRs)
   Position: hg19 chr11:110,045,605-110,167,437 Size: 121,833 Total Exon Count: 17 Strand: -


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA DescriptionsPathwaysOther Names
GeneReviewsModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:110,045,605-110,167,437)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblEntrez GeneExonPrimerH-INVHGNC
LynxMalacardsOMIMPubMedWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RDX
CDC HuGE Published Literature: RDX
Positive Disease Associations: Arteries , Myocardial Infarction
Related Studies:
  1. Arteries
    , , . [PubMed 0]
  2. Myocardial Infarction
    , , . [PubMed 0]
  3. Myocardial Infarction
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: RDX
Diseases sorted by gene-association score: deafness, autosomal recessive 24* (1246), nonsyndromic hearing loss and deafness* (283), autosomal recessive non-syndromic sensorineural deafness type dfnb* (117), dfnb24 nonsyndromic hearing loss and deafness* (100), nonsyndromic deafness* (81), neurofibromatosis, type 2 (21), kindler syndrome (9), meningioma, familial (6), pathologic nystagmus (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 99.50 RPKM in Adrenal Gland
Total median expression: 732.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  DQ916741 - Homo sapiens radixin isoform e (RDX) mRNA, complete cds, alternatively spliced.
DQ916742 - Homo sapiens radixin isoform f (RDX) mRNA, complete cds, alternatively spliced.
DQ916738 - Homo sapiens radixin isoform b (RDX) mRNA, complete cds, alternatively spliced.
DQ916739 - Homo sapiens radixin isoform c (RDX) mRNA, complete cds, alternatively spliced.
DQ916740 - Homo sapiens radixin isoform d (RDX) mRNA, complete cds, alternatively spliced.
AL137751 - Homo sapiens mRNA; cDNA DKFZp434I0812 (from clone DKFZp434I0812); partial cds.
BX648536 - Homo sapiens mRNA; cDNA DKFZp779D2226 (from clone DKFZp779D2226).
BC047109 - Homo sapiens radixin, mRNA (cDNA clone MGC:48283 IMAGE:5284438), complete cds.
JD278683 - Sequence 259707 from Patent EP1572962.
AK295075 - Homo sapiens cDNA FLJ58499 complete cds, highly similar to Radixin.
L02320 - Human radixin mRNA, complete cds.
AK316061 - Homo sapiens cDNA, FLJ78960 complete cds, highly similar to Radixin.
AK312903 - Homo sapiens cDNA, FLJ93349, Homo sapiens radixin (RDX), mRNA.
KJ897461 - Synthetic construct Homo sapiens clone ccsbBroadEn_06855 RDX gene, encodes complete protein.
KR710945 - Synthetic construct Homo sapiens clone CCSBHm_00018338 RDX (RDX) mRNA, encodes complete protein.
AB527544 - Synthetic construct DNA, clone: pF1KB6120, Homo sapiens RDX gene for radixin, without stop codon, in Flexi system.
BC020751 - Homo sapiens radixin, mRNA (cDNA clone IMAGE:4691774), partial cds.
BC002626 - Homo sapiens radixin, mRNA (cDNA clone IMAGE:3607251), partial cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04810 - Regulation of actin cytoskeleton

-  Other Names for This Gene
  Alternate Gene Symbols: DQ916741, NM_001260493
UCSC ID: uc009yxx.1
RefSeq Accession: NM_001260493

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene RDX:
deafness-overview (Genetic Hearing Loss Overview)

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: DQ916741.1
exon count: 17CDS single in 3' UTR: no RNA size: 2558
ORF size: 0CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 3430.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.