Description: Homo sapiens glutamate receptor, ionotropic, kainate 4 (GRIK4), mRNA. RefSeq Summary (NM_014619): This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]. Transcript (Including UTRs) Position: hg19 chr11:120,530,978-120,856,969 Size: 325,992 Total Exon Count: 19 Strand: + Coding Region Position: hg19 chr11:120,531,028-120,856,969 Size: 325,942 Coding Exon Count: 19
ID:GRIK4_HUMAN DESCRIPTION: RecName: Full=Glutamate receptor, ionotropic kainate 4; AltName: Full=Excitatory amino acid receptor 1; Short=EAA1; AltName: Full=Glutamate receptor KA-1; Short=KA1; Flags: Precursor; FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. SUBUNIT: Forms a heteromeric channel with GRIK1 or GRIK3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
Cognitive performance Cirulli ,et al. Eur J Hum Genet 2010, Common genetic variation and performance on standardized cognitive tests , European journal of human genetics : EJHG 2010 .
[PubMed 20125193]
Hematocrit Qiong Yang et al. BMC medical genetics 2007, Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903294]
Using genome-wide association methodology, we have successfully identified a SNP in complete LD with a sequence variant previously shown to be strongly associated with factor VII, providing proof of principle for this approach. Further study of additional strongly associated SNPs and linked regions may identify novel variants that influence the inter-individual variability in hemostatic factors and hematological phenotypes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00060 - Ligand-gated ion channel PF00497 - Bacterial extracellular solute-binding proteins, family 3 PF01094 - Receptor family ligand binding region PF10613 - Ligated ion channel L-glutamate- and glycine-binding site
SCOP Domains: 53822 - Periplasmic binding protein-like I 53850 - Periplasmic binding protein-like II
ModBase Predicted Comparative 3D Structure on Q16099
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK292726 - Homo sapiens cDNA FLJ77953 complete cds, highly similar to Homo sapiens glutamate receptor, ionotropic, kainate 4 (GRIK4), mRNA. AK314284 - Homo sapiens cDNA, FLJ95040, highly similar to Homo sapiens glutamate receptor, ionotropic, kainate 4 (GRIK4), mRNA. BC146652 - Homo sapiens glutamate receptor, ionotropic, kainate 4, mRNA (cDNA clone MGC:164809 IMAGE:40147575), complete cds. BC150173 - Homo sapiens glutamate receptor, ionotropic, kainate 4, mRNA (cDNA clone MGC:164786 IMAGE:40147389), complete cds. AB384776 - Synthetic construct DNA, clone: pF1KB3287, Homo sapiens GRIK4 gene for glutamate receptor, ionotropic kainate 4 precursor, complete cds, without stop codon, in Flexi system. S67803 - excitatory amino acid receptor 1=glutamate ionotropic receptor [human, hippocampus, mRNA Partial, 2871 nt].
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04080 - Neuroactive ligand-receptor interaction
Reactome (by CSHL, EBI, and GO)
Protein Q16099 (Reactome details) participates in the following event(s):
R-HSA-451283 kainate receptor binds glutamate R-HSA-451311 Activation of Ca-permeable Kainate receptors R-HSA-451308 Activation of Ca-permeable Kainate Receptor R-HSA-451306 Ionotropic activity of kainate receptors R-HSA-451326 Activation of kainate receptors upon glutamate binding R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System