Description: Homo sapiens DIP2 disco-interacting protein 2 homolog B (Drosophila) (DIP2B), mRNA. RefSeq Summary (NM_173602): This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr12:51,079,616-51,142,450 Size: 62,835 Total Exon Count: 27 Strand: + Coding Region Position: hg19 chr12:51,086,788-51,138,622 Size: 51,835 Coding Exon Count: 25
ID:DIP2B_HUMAN DESCRIPTION: RecName: Full=Disco-interacting protein 2 homolog B; Short=DIP2 homolog B; TISSUE SPECIFICITY: Moderately expressed in adult brain, placenta, skeletal muscle, heart, kidney, pancreas, lung, spleen and colon. Expression was weaker in adult liver, kidney, spleen, and ovary, and in fetal brain and liver. In the brain, it is expressed in the cerebral cortex; the frontal, parietal, occipital and temporal lobes; the paracentral gyrus; the pons; the corpus callosum and the hippocampus. Highest expression levels in the brain were found in the cerebral cortex and the frontal and parietal lobes. SIMILARITY: Belongs to the DIP2 family. SEQUENCE CAUTION: Sequence=AAH75027.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=BAC03705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=BAC05025.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW58149.1; Type=Erroneous gene model prediction;
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): DIP2B CDC HuGE Published Literature: DIP2B Positive Disease Associations: Colorectal Neoplasms Related Studies:
Colorectal Neoplasms Richard S Houlston et al. Nature genetics 2010, Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33., Nature genetics.
[PubMed 20972440]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P265
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
