Description: Homo sapiens phosphodiesterase 1B, calmodulin-dependent (PDE1B), transcript variant 2, mRNA. RefSeq Summary (NM_001165975): The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. Transcript (Including UTRs) Position: hg19 chr12:54,955,228-54,973,023 Size: 17,796 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr12:54,966,403-54,971,112 Size: 4,710 Coding Exon Count: 9
ID:PDE1B_HUMAN DESCRIPTION: RecName: Full=Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Short=Cam-PDE 1B; EC=3.1.4.17; AltName: Full=63 kDa Cam-PDE; FUNCTION: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ENZYME REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+). SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01064
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.