Description: Homo sapiens RNA binding motif, single stranded interacting protein 2 (RBMS2), mRNA. RefSeq Summary (NM_002898): The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr12:56,915,609-56,989,980 Size: 74,372 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr12:56,975,290-56,983,045 Size: 7,756 Coding Exon Count: 8
Adiponectin Zari Dastani et al. PLoS genetics 2012, Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals., PLoS genetics.
[PubMed 22479202]
Amyotrophic Lateral Sclerosis Jennifer C Schymick et al. Lancet neurology 2007, Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data., Lancet neurology.
[PubMed 17362836]
We generated publicly available genotype data for sporadic ALS patients and controls. No single locus was definitively associated with increased risk of developing disease, although potentially associated candidate SNPs were identified.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC072679 - Homo sapiens RNA binding motif, single stranded interacting protein 2, mRNA (cDNA clone MGC:88016 IMAGE:6048623), complete cds. AK308885 - Homo sapiens cDNA, FLJ98926. AK304540 - Homo sapiens cDNA FLJ50371 complete cds, highly similar to RNA-binding motif,single-stranded-interacting protein 2. AK293315 - Homo sapiens cDNA FLJ60228 complete cds, highly similar to RNA-binding motif, single-stranded-interacting protein 2. JD503520 - Sequence 484544 from Patent EP1572962. D28483 - Homo sapiens scr3 mRNA for RNA binding protein SCR3, complete cds. AK299580 - Homo sapiens cDNA FLJ53090 complete cds, moderately similar to RNA-binding motif, single-stranded-interacting protein 2. BC027863 - Homo sapiens RNA binding motif, single stranded interacting protein 2, mRNA (cDNA clone MGC:34559 IMAGE:5202634), complete cds. CU693300 - Synthetic construct Homo sapiens gateway clone IMAGE:100019266 5' read RBMS2 mRNA. KJ897455 - Synthetic construct Homo sapiens clone ccsbBroadEn_06849 RBMS2 gene, encodes complete protein. JD296834 - Sequence 277858 from Patent EP1572962. JD286111 - Sequence 267135 from Patent EP1572962. GU228575 - Homo sapiens LSINCT3 non-coding RNA, partial sequence. AK125252 - Homo sapiens cDNA FLJ43262 fis, clone HLUNG2003003. JD415699 - Sequence 396723 from Patent EP1572962. AK097342 - Homo sapiens cDNA FLJ40023 fis, clone STOMA2007680. JD513904 - Sequence 494928 from Patent EP1572962. JD120533 - Sequence 101557 from Patent EP1572962. AK096412 - Homo sapiens cDNA FLJ39093 fis, clone NT2RP7020112.
US Server
