Human Gene TMTC3 (uc009zsm.2)
  Description: Homo sapiens transmembrane and tetratricopeptide repeat containing 3 (TMTC3), mRNA.
RefSeq Summary (NM_181783): This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010].
Transcript (Including UTRs)
   Position: hg19 chr12:88,536,073-88,582,723 Size: 46,651 Total Exon Count: 12 Strand: +


Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:88,536,073-88,582,723)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGeneNetworkH-INVHGNCLynx
MalacardsPubMed

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TMTC3
Diseases sorted by gene-association score: lissencephaly 8* (1228), lissencephaly (15), pachygyria (8), cobblestone lissencephaly (5), walker-warburg syndrome (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.43 RPKM in Cells - Cultured fibroblasts
Total median expression: 137.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK310393 - Homo sapiens cDNA, FLJ17435.
AK310375 - Homo sapiens cDNA, FLJ17417.
AK290436 - Homo sapiens cDNA FLJ78524 complete cds, highly similar to Homo sapiens SMILE protein (SMILE), mRNA.
AK302755 - Homo sapiens cDNA FLJ52097 complete cds, weakly similar to Homo sapiens transmembrane and tetratricopeptide repeat containing 1 (TMTC1), mRNA.
CR749309 - Homo sapiens mRNA; cDNA DKFZp686O22167 (from clone DKFZp686O22167).
BX538169 - Homo sapiens mRNA; cDNA DKFZp686I16123 (from clone DKFZp686I16123); complete cds.
JD437346 - Sequence 418370 from Patent EP1572962.
JD044283 - Sequence 25307 from Patent EP1572962.
CR749244 - Homo sapiens mRNA; cDNA DKFZp686M1969 (from clone DKFZp686M1969).
CR933632 - Homo sapiens mRNA; cDNA DKFZp686C0968 (from clone DKFZp686C0968).
JD329294 - Sequence 310318 from Patent EP1572962.
AJ697717 - Homo sapiens mRNA for SMILE protein.
BC117177 - Homo sapiens transmembrane and tetratricopeptide repeat containing 3, mRNA (cDNA clone MGC:150786 IMAGE:40125728), complete cds.
BC117175 - Homo sapiens transmembrane and tetratricopeptide repeat containing 3, mRNA (cDNA clone MGC:150784 IMAGE:40125726), complete cds.
LF211709 - JP 2014500723-A/19212: Polycomb-Associated Non-Coding RNAs.
AM393797 - Synthetic construct Homo sapiens clone IMAGE:100002236 for hypothetical protein (TMTC3 gene).
HQ258675 - Synthetic construct Homo sapiens clone IMAGE:100072705 transmembrane and tetratricopeptide repeat containing 3 (TMTC3) gene, encodes complete protein.
KJ895713 - Synthetic construct Homo sapiens clone ccsbBroadEn_05107 TMTC3 gene, encodes complete protein.
AK074973 - Homo sapiens cDNA FLJ90492 fis, clone NT2RP3003535, weakly similar to UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KD SUBUNIT (EC 2.4.1.-).
LF382927 - JP 2014500723-A/190430: Polycomb-Associated Non-Coding RNAs.
JD243982 - Sequence 225006 from Patent EP1572962.
JD089713 - Sequence 70737 from Patent EP1572962.
JD147104 - Sequence 128128 from Patent EP1572962.
LF382926 - JP 2014500723-A/190429: Polycomb-Associated Non-Coding RNAs.
LF382925 - JP 2014500723-A/190428: Polycomb-Associated Non-Coding RNAs.
CR936640 - Homo sapiens mRNA; cDNA DKFZp686O2342 (from clone DKFZp686O2342).
LF382924 - JP 2014500723-A/190427: Polycomb-Associated Non-Coding RNAs.
MA618504 - JP 2018138019-A/190430: Polycomb-Associated Non-Coding RNAs.
MA618503 - JP 2018138019-A/190429: Polycomb-Associated Non-Coding RNAs.
MA618502 - JP 2018138019-A/190428: Polycomb-Associated Non-Coding RNAs.
MA618501 - JP 2018138019-A/190427: Polycomb-Associated Non-Coding RNAs.
MA447286 - JP 2018138019-A/19212: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK310375
UCSC ID: uc009zsm.2
RefSeq Accession: NM_181783

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: AK310375.1
exon count: 12CDS single in 3' UTR: no RNA size: 1842
ORF size: 0CDS single in intron: no Alignment % ID: 99.89
txCdsPredict score: 2137.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.