Description: Homo sapiens polymerase (DNA directed), epsilon, catalytic subunit (POLE), mRNA. RefSeq Summary (NM_006231): This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr12:133,219,810-133,263,945 Size: 44,136 Total Exon Count: 34 Strand: - Coding Region Position: hg19 chr12:133,219,810-133,263,901 Size: 44,092 Coding Exon Count: 34
ID:F5H1D6_HUMAN DESCRIPTION: RecName: Full=DNA polymerase; EC=2.7.7.7; CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SIMILARITY: Belongs to the DNA polymerase type-B family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00136 - DNA polymerase family B PF03104 - DNA polymerase family B, exonuclease domain PF10108 - Predicted 3'-5' exonuclease related to the exonuclease domain of PolB PF13482 - RNase_H superfamily
ModBase Predicted Comparative 3D Structure on F5H1D6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.