Human Gene RXFP2 (uc010aba.3)
  Description: Homo sapiens relaxin/insulin-like family peptide receptor 2 (RXFP2), transcript variant 2, mRNA.
RefSeq Summary (NM_001166058): This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Transcript (Including UTRs)
   Position: hg19 chr13:32,313,679-32,377,009 Size: 63,331 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr13:32,313,750-32,376,542 Size: 62,793 Coding Exon Count: 17 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:32,313,679-32,377,009)mRNA (may differ from genome)Protein (730 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCLynxMalacardsMGIOMIMPubMed
ReactomeTreefamUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RXFP2
CDC HuGE Published Literature: RXFP2

-  MalaCards Disease Associations
  MalaCards Gene Search: RXFP2
Diseases sorted by gene-association score: cryptorchidism* (184), testicular cancer (12), anorchia (8), infertility (6), physical disorder (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.35 RPKM in Fallopian Tube
Total median expression: 1.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.1071-0.128 Picture PostScript Text
3' UTR -129.50467-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF00057 - Low-density lipoprotein receptor domain class A
PF00560 - Leucine Rich Repeat
PF13306 - Leucine rich repeats (6 copies)
PF13516 - Leucine Rich repeat
PF13855 - Leucine rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1
81321 - Family A G protein-coupled receptor-like
57424 - LDL receptor-like module

ModBase Predicted Comparative 3D Structure on Q8WXD0-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AF453828 - Homo sapiens G protein-coupled receptor affecting testicular descent (GREAT) mRNA, complete cds.
AF403384 - Homo sapiens LGR8 mRNA, complete cds.
AB527208 - Synthetic construct DNA, clone: pF1KE0367, Homo sapiens RXFP2 gene for relaxin/insulin-like family peptide receptor 2, without stop codon, in Flexi system.
BC146279 - Synthetic construct Homo sapiens clone IMAGE:100015252, MGC:180268 relaxin/insulin-like family peptide receptor 2 (RXFP2) mRNA, encodes complete protein.
BC148729 - Synthetic construct Homo sapiens clone IMAGE:100015769, MGC:183167 relaxin/insulin-like family peptide receptor 2 (RXFP2) mRNA, encodes complete protein.
AY899851 - Homo sapiens LGR8.1 mRNA, complete cds, alternatively spliced.
JD036770 - Sequence 17794 from Patent EP1572962.
JD077077 - Sequence 58101 from Patent EP1572962.
JD098180 - Sequence 79204 from Patent EP1572962.
JD256111 - Sequence 237135 from Patent EP1572962.
JD489552 - Sequence 470576 from Patent EP1572962.
JD494664 - Sequence 475688 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein Q8WXD0 (Reactome details) participates in the following event(s):

R-HSA-444879 Relaxin receptor 2 binds relaxin 2 and INSL3
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-444821 Relaxin receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: GPR106, GREAT, LGR8, NM_001166058, NP_001159530, Q8WXD0-2
UCSC ID: uc010aba.3
RefSeq Accession: NM_001166058
Protein: Q8WXD0-2, splice isoform of Q8WXD0 CCDS: CCDS9342.1, CCDS53862.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001166058.1
exon count: 17CDS single in 3' UTR: no RNA size: 2731
ORF size: 2193CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4311.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.