Human Gene WDFY2 (uc010ads.1)
Description: Homo sapiens WD repeat and FYVE domain containing 2 (WDFY2), mRNA.RefSeq Summary (NM_052950): This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr13:52,158,484-52,325,801 Size: 167,318 Total Exon Count: 8 Strand: +Coding Region Position: hg19 chr13:52,158,824-52,325,632 Size: 166,809 Coding Exon Count: 8
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: WDFY2_HUMAN DESCRIPTION: RecName: Full=WD repeat and FYVE domain-containing protein 2; AltName: Full=WD40- and FYVE domain-containing protein 2; AltName: Full=Zinc finger FYVE domain-containing protein 22;SIMILARITY: Contains 1 FYVE-type zinc finger.SIMILARITY: Contains 7 WD repeats.
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: WDFY2
Diseases sorted by gene-association score: balantidiasis (6), pulmonary embolism and infarction (3), perinephritis (2), ophthalmia neonatorum (2), lung papillary adenocarcinoma (2), alexia (2), balo concentric sclerosis (2), accommodative esotropia (2), prolapse of female genital organ (2), enterocele (2), superior mesenteric artery syndrome (1), chronic dacryocystitis (1), chronic inflammation of lacrimal passage (1), papillary hidradenoma (1), multiple personality disorder (1), angiomatous meningioma (1), enterobiasis (1), nodular malignant melanoma (1), acute pulmonary heart disease (1), brachial plexus lesion (1), juxtacortical osteosarcoma (1), exanthema subitum (1), peripheral osteosarcoma (1), coproporphyria (1)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR020472 - G-protein_beta_WD-40_repIPR015943 - WD40/YVTN_repeat-like_domIPR001680 - WD40_repeatIPR019775 - WD40_repeat_CSIPR017986 - WD40_repeat_domIPR000306 - Znf_FYVEIPR017455 - Znf_FYVE-relIPR011011 - Znf_FYVE_PHDIPR013083 - Znf_RING/FYVE/PHDPfam Domains: PF00400 - WD domain, G-beta repeatSCOP Domains: 50952 - Soluble quinoprotein glucose dehydrogenase50960 - TolB, C-terminal domain63825 - YWTD domain63829 - Calcium-dependent phosphotriesterase69304 - Tricorn protease N-terminal domain101898 - NHL repeat50965 - Galactose oxidase, central domain75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme101908 - Putative isomerase YbhE50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase50974 - Nitrous oxide reductase, N-terminal domain50978 - WD40 repeat-like50993 - Prolyl oligopeptidase, N-terminal domain69322 - Tricorn protease domain 250998 - Quinoprotein alcohol dehydrogenase-like51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase82171 - Dipeptidyl peptidase IV/CD26, N-terminal domainModBase Predicted Comparative 3D Structure on Q96P53 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog Gene Details Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK311177 - Homo sapiens cDNA, FLJ18219.AK309815 - Homo sapiens cDNA, FLJ99856.BC014004 - Homo sapiens WD repeat and FYVE domain containing 2, mRNA (cDNA clone MGC:20275 IMAGE:3842589), complete cds.CU680736 - Synthetic construct Homo sapiens gateway clone IMAGE:100023390 5' read WDFY2 mRNA.HQ448154 - Synthetic construct Homo sapiens clone IMAGE:100071539; CCSB007075_01 WD repeat and FYVE domain containing 2 (WDFY2) gene, encodes complete protein.KJ895294 - Synthetic construct Homo sapiens clone ccsbBroadEn_04688 WDFY2 gene, encodes complete protein.AF411978 - Homo sapiens WD40- and FYVE-domain containing protein 2 (WDF2) mRNA, complete cds.AK058149 - Homo sapiens cDNA FLJ25420 fis, clone TST03665.LF210118 - JP 2014500723-A/17621: Polycomb-Associated Non-Coding RNAs.LF334750 - JP 2014500723-A/142253: Polycomb-Associated Non-Coding RNAs.JD323301 - Sequence 304325 from Patent EP1572962.MA445695 - JP 2018138019-A/17621: Polycomb-Associated Non-Coding RNAs.MA570327 - JP 2018138019-A/142253: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: AK309815, B1AL86, NM_052950, NP_443182, Q96CS1, Q96P53, WDF2, WDFY2_HUMAN, ZFYVE22UCSC ID: uc010ads.1RefSeq Accession: NM_052950 Protein: Q96P53
(aka WDFY2_HUMAN or WDF2_HUMAN)
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AK309815.1
exon count:
8 CDS single in 3' UTR:
no
RNA size:
1276 ORF size:
912 CDS single in intron:
no
Alignment % ID:
99.92 txCdsPredict score:
1886.00 frame shift in genome:
no
% Coverage:
99.84 has start codon:
yes
stop codon in genome:
no
# of Alignments:
1 has end codon:
yes
retained intron:
no
# AT/AC introns
0 selenocysteine:
no
end bleed into intron:
250 # strange splices:
0
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Methods, Credits, and Use Restrictions
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US Server
