Human Gene KHNYN (uc010alw.3)
  Description: Homo sapiens KH and NYN domain containing (KHNYN), mRNA.
RefSeq Summary (NM_015299): This gene encodes a protein containing a ribonuclease NYN domain. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Transcript (Including UTRs)
   Position: hg19 chr14:24,899,160-24,910,547 Size: 11,388 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr14:24,899,937-24,906,491 Size: 6,555 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:24,899,160-24,910,547)mRNA (may differ from genome)Protein (678 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KHNYN_HUMAN
DESCRIPTION: RecName: Full=Protein KHNYN; AltName: Full=KH and NYN domain-containing protein;
SIMILARITY: Belongs to the N4BP1 family.
SEQUENCE CAUTION: Sequence=BAA20781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KHNYN
CDC HuGE Published Literature: KHNYN

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.35 RPKM in Ovary
Total median expression: 462.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.6055-0.375 Picture PostScript Text
3' UTR -1501.184056-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021869 - RNase_Zc3h12

Pfam Domains:
PF11977 - Zc3h12a-like Ribonuclease NYN domain

ModBase Predicted Comparative 3D Structure on O15037
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003723 RNA binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  AB002321 - Homo sapiens mRNA for KIAA0323 gene.
AB383849 - Synthetic construct DNA, clone: pF1KSDA0323, Homo sapiens KIAA0323 gene for KIAA0323 protein, complete cds, without stop codon, in Flexi system.
LF210095 - JP 2014500723-A/17598: Polycomb-Associated Non-Coding RNAs.
AK291680 - Homo sapiens cDNA FLJ75063 complete cds.
BX161465 - human full-length cDNA clone CS0DI064YL03 of Placenta of Homo sapiens (human).
BC042554 - Homo sapiens KIAA0323, mRNA (cDNA clone MGC:35260 IMAGE:5173707), complete cds.
KJ904685 - Synthetic construct Homo sapiens clone ccsbBroadEn_14079 KHNYN-like gene, encodes complete protein.
BC015780 - Homo sapiens KIAA0323, mRNA (cDNA clone IMAGE:4856920), partial cds.
MA445672 - JP 2018138019-A/17598: Polycomb-Associated Non-Coding RNAs.
LF334580 - JP 2014500723-A/142083: Polycomb-Associated Non-Coding RNAs.
LF334581 - JP 2014500723-A/142084: Polycomb-Associated Non-Coding RNAs.
LF334582 - JP 2014500723-A/142085: Polycomb-Associated Non-Coding RNAs.
LF334583 - JP 2014500723-A/142086: Polycomb-Associated Non-Coding RNAs.
LF334584 - JP 2014500723-A/142087: Polycomb-Associated Non-Coding RNAs.
LF334585 - JP 2014500723-A/142088: Polycomb-Associated Non-Coding RNAs.
LF334586 - JP 2014500723-A/142089: Polycomb-Associated Non-Coding RNAs.
MA570157 - JP 2018138019-A/142083: Polycomb-Associated Non-Coding RNAs.
MA570158 - JP 2018138019-A/142084: Polycomb-Associated Non-Coding RNAs.
MA570159 - JP 2018138019-A/142085: Polycomb-Associated Non-Coding RNAs.
MA570160 - JP 2018138019-A/142086: Polycomb-Associated Non-Coding RNAs.
MA570161 - JP 2018138019-A/142087: Polycomb-Associated Non-Coding RNAs.
MA570162 - JP 2018138019-A/142088: Polycomb-Associated Non-Coding RNAs.
MA570163 - JP 2018138019-A/142089: Polycomb-Associated Non-Coding RNAs.
JD424043 - Sequence 405067 from Patent EP1572962.
LF334589 - JP 2014500723-A/142092: Polycomb-Associated Non-Coding RNAs.
JD348451 - Sequence 329475 from Patent EP1572962.
JD557739 - Sequence 538763 from Patent EP1572962.
JD455681 - Sequence 436705 from Patent EP1572962.
LF334590 - JP 2014500723-A/142093: Polycomb-Associated Non-Coding RNAs.
LF334591 - JP 2014500723-A/142094: Polycomb-Associated Non-Coding RNAs.
JD360720 - Sequence 341744 from Patent EP1572962.
LF334592 - JP 2014500723-A/142095: Polycomb-Associated Non-Coding RNAs.
LF210096 - JP 2014500723-A/17599: Polycomb-Associated Non-Coding RNAs.
LF334593 - JP 2014500723-A/142096: Polycomb-Associated Non-Coding RNAs.
LF334594 - JP 2014500723-A/142097: Polycomb-Associated Non-Coding RNAs.
LF334595 - JP 2014500723-A/142098: Polycomb-Associated Non-Coding RNAs.
JD343589 - Sequence 324613 from Patent EP1572962.
JD207843 - Sequence 188867 from Patent EP1572962.
JD073804 - Sequence 54828 from Patent EP1572962.
MA570166 - JP 2018138019-A/142092: Polycomb-Associated Non-Coding RNAs.
MA570167 - JP 2018138019-A/142093: Polycomb-Associated Non-Coding RNAs.
MA570168 - JP 2018138019-A/142094: Polycomb-Associated Non-Coding RNAs.
MA570169 - JP 2018138019-A/142095: Polycomb-Associated Non-Coding RNAs.
MA445673 - JP 2018138019-A/17599: Polycomb-Associated Non-Coding RNAs.
MA570170 - JP 2018138019-A/142096: Polycomb-Associated Non-Coding RNAs.
MA570171 - JP 2018138019-A/142097: Polycomb-Associated Non-Coding RNAs.
MA570172 - JP 2018138019-A/142098: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK291680, KHNYN_HUMAN, KIAA0323, NM_015299, NP_056114, O15037, Q86TZ6, Q8IUQ2, Q96BA9
UCSC ID: uc010alw.3
RefSeq Accession: NM_015299
Protein: O15037 (aka KHNYN_HUMAN)
CCDS: CCDS32058.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK291680.1
exon count: 8CDS single in 3' UTR: no RNA size: 2424
ORF size: 2037CDS single in intron: no Alignment % ID: 99.71
txCdsPredict score: 4231.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.