Human Gene FAM181A (uc010aus.2)
  Description: Homo sapiens family with sequence similarity 181, member A (FAM181A), transcript variant 4, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr14:94,393,689-94,395,954 Size: 2,266 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr14:94,394,632-94,395,510 Size: 879 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:94,393,689-94,395,954)mRNA (may differ from genome)Protein (292 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsH-INVHGNC
HPRDLynxMGIneXtProtPubMedTreefam
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F181A_HUMAN
DESCRIPTION: RecName: Full=Protein FAM181A;
SIMILARITY: Belongs to the FAM181 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.20 RPKM in Testis
Total median expression: 60.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -91.30199-0.459 Picture PostScript Text
3' UTR -188.10444-0.424 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15238 - FAM181

ModBase Predicted Comparative 3D Structure on Q8N9Y4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK093387 - Homo sapiens cDNA FLJ36068 fis, clone TESTI2019352.
AX748092 - Sequence 1617 from Patent EP1308459.
AK315393 - Homo sapiens cDNA, FLJ96441.
BC009073 - Homo sapiens family with sequence similarity 181, member A, mRNA (cDNA clone MGC:9764 IMAGE:3856004), complete cds.
JD459060 - Sequence 440084 from Patent EP1572962.
AY255795 - Homo sapiens HSD-31 mRNA, complete cds.
KJ903536 - Synthetic construct Homo sapiens clone ccsbBroadEn_12930 FAM181A gene, encodes complete protein.
JD190923 - Sequence 171947 from Patent EP1572962.
JD136670 - Sequence 117694 from Patent EP1572962.
JD233072 - Sequence 214096 from Patent EP1572962.
JD355917 - Sequence 336941 from Patent EP1572962.
JD397551 - Sequence 378575 from Patent EP1572962.
JD118704 - Sequence 99728 from Patent EP1572962.
JD103702 - Sequence 84726 from Patent EP1572962.
JD454839 - Sequence 435863 from Patent EP1572962.
JD322566 - Sequence 303590 from Patent EP1572962.
JD147946 - Sequence 128970 from Patent EP1572962.
JD166168 - Sequence 147192 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD39, C14orf152, F181A_HUMAN, HSD-31, HSD31, NM_001207073, NP_001194003, Q8N9Y4, Q96GY1
UCSC ID: uc010aus.2
RefSeq Accession: NM_001207073
Protein: Q8N9Y4 (aka F181A_HUMAN)
CCDS: CCDS55939.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001207073.1
exon count: 2CDS single in 3' UTR: no RNA size: 1536
ORF size: 879CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1540.00frame shift in genome: no % Coverage: 99.09
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.