ID:LIPC_HUMAN DESCRIPTION: RecName: Full=Hepatic triacylglycerol lipase; Short=HL; Short=Hepatic lipase; EC=3.1.1.3; AltName: Full=Lipase member C; Flags: Precursor; FUNCTION: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. SUBCELLULAR LOCATION: Secreted. POLYMORPHISM: Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus 12 (HDLCQ12) [MIM:612797]. POLYMORPHISM: Genetic variations in LIPC are associated with non- insulin-dependent diabetes mellitus susceptibility (NIDDM susceptibility) [MIM:125853]. DISEASE: Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency) [MIM:614025]. A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family. SIMILARITY: Contains 1 PLAT domain. WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LIPC";
Amyotrophic lateral sclerosis van Es ,et al. 2007, Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis, .
[PubMed 18084291]
Amyotrophic Lateral Sclerosis Michael A van Es et al. Nature genetics 2008, Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis., Nature genetics.
[PubMed 18084291]
atherosclerosis, coronary Baroni, M. G. et al. 2003, Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associateswith clinical outcomes in patients with established CAD., BMC medical genetics [electronic resource]. 2003 Sep;4:8.
[PubMed 12964943]
variation in LIPC (hepatic lipase) gene associates with clinical outcomes in Italian patients with established CAD. Further studies on the LIPC gene in CAD patients are warranted, in particular looking at the possible influences on clinical outcomes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P11150
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.