Description: Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. RefSeq Summary (NM_000499): This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]. Transcript (Including UTRs) Position: hg19 chr15:75,011,883-75,017,877 Size: 5,995 Total Exon Count: 8 Strand: -
1-hydroxypyrene, urinary Leng, S. G. et al. 2004, [Effect of genetic polymorphisms of microsomal epoxide hydrolase on urinary 1-hydroxypyrene levels in coke oven workers], Zhonghua lao dong wei sheng zhi ye bing za zhi. 2004 Aug;22(4):245-9.
[PubMed 15355699]
Genetic polymorphism of mEH gene could be a susceptible biomarker in coke oven workers which was involved in the individual susceptibility on metabolism of PAHs.
acute coronary syndrome Martin D Jarvis , et al. Clinical and experimental pharmacology & physiology 2009 Jul, CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients., Clinical and experimental pharmacology & physiology 2009 Jul.
[PubMed 19650794]
adenocarcinoma of the lung Taioli E et al. 1995, A specific African-American CYP1A1 polymorphism is associated with adenocarcinoma of the lung., Cancer research. 1995 Feb;55(3):472-3.
[PubMed 7834609]
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC023019 - Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1, mRNA (cDNA clone MGC:29888 IMAGE:5123393), complete cds. LF208519 - JP 2014500723-A/16022: Polycomb-Associated Non-Coding RNAs. K03191 - Human cytochrome P-1-450 (TCDD-inducible) mRNA, complete cds. JD303122 - Sequence 284146 from Patent EP1572962. JD428934 - Sequence 409958 from Patent EP1572962. JD373673 - Sequence 354697 from Patent EP1572962. JD423272 - Sequence 404296 from Patent EP1572962. JD555753 - Sequence 536777 from Patent EP1572962. JD098910 - Sequence 79934 from Patent EP1572962. JD188735 - Sequence 169759 from Patent EP1572962. JD470962 - Sequence 451986 from Patent EP1572962. AK310810 - Homo sapiens cDNA, FLJ17852. JD477367 - Sequence 458391 from Patent EP1572962. AH007293 - Homo sapiens cytochrome P450 1A1 (CYP1A1) mRNA, partial cds. JD175082 - Sequence 156106 from Patent EP1572962. JD400488 - Sequence 381512 from Patent EP1572962. AK223113 - Homo sapiens mRNA for cytochrome P450, family 1, subfamily A, polypeptide 1 variant, clone: KAT09250. JD482187 - Sequence 463211 from Patent EP1572962. JD399774 - Sequence 380798 from Patent EP1572962. AK223108 - Homo sapiens mRNA for cytochrome P450, family 1, subfamily A, polypeptide 1 variant, clone: KAT07566. AM236046 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), splice variant 5. AM236047 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), splice variant 6. JD479689 - Sequence 460713 from Patent EP1572962. AY871801 - Homo sapiens cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) mRNA, complete cds, alternatively spliced. JD266306 - Sequence 247330 from Patent EP1572962. DQ891515 - Synthetic construct clone IMAGE:100004145; FLH177640.01X; RZPDo839C05126D cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene, encodes complete protein. AY310359 - Homo sapiens cytochrome P450 1A1 variant (CYP1A1) mRNA, complete cds; alternatively spliced. E10856 - cDNA encoding human cytochrome P450. E10857 - cDNA encoding human cytochrome P450. E10858 - cDNA encoding human cytochrome P450. E11493 - cDNA encoding human cytochrome P-4501A1. AK313880 - Homo sapiens cDNA, FLJ94514, Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1(CYP1A1), mRNA. KJ891012 - Synthetic construct Homo sapiens clone ccsbBroadEn_00406 CYP1A1 gene, encodes complete protein. KR710640 - Synthetic construct Homo sapiens clone CCSBHm_00015154 CYP1A1 (CYP1A1) mRNA, encodes complete protein. KR710641 - Synthetic construct Homo sapiens clone CCSBHm_00015155 CYP1A1 (CYP1A1) mRNA, encodes complete protein. DQ894706 - Synthetic construct Homo sapiens clone IMAGE:100009166; FLH177636.01L; RZPDo839C05125D cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene, encodes complete protein. M12079 - Human cytochrome P-450 6 mRNA, partial cds. AM233517 - Homo sapiens partial mRNA for cytochrome P450 1A1 (CYP1A1 gene), alternative splice variant 1. AM233518 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), alternative splice variant 2. AM233519 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), alternative splice variant 3. AM233520 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), alternative splice variant 4. CU692778 - Synthetic construct Homo sapiens gateway clone IMAGE:100019740 5' read CYP1A1 mRNA. LF377234 - JP 2014500723-A/184737: Polycomb-Associated Non-Coding RNAs. JD493249 - Sequence 474273 from Patent EP1572962. JD380587 - Sequence 361611 from Patent EP1572962. JD119197 - Sequence 100221 from Patent EP1572962. MA444096 - JP 2018138019-A/16022: Polycomb-Associated Non-Coding RNAs. MA612811 - JP 2018138019-A/184737: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00140 - Steroid hormone biosynthesis hsa00380 - Tryptophan metabolism hsa00830 - Retinol metabolism hsa00980 - Metabolism of xenobiotics by cytochrome P450