Description: Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. RefSeq Summary (NM_000499): This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]. Transcript (Including UTRs) Position: hg19 chr15:75,013,061-75,017,877 Size: 4,817 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr15:75,013,304-75,014,646 Size: 1,343 Coding Exon Count: 5
1-hydroxypyrene, urinary Leng, S. G. et al. 2004, [Effect of genetic polymorphisms of microsomal epoxide hydrolase on urinary 1-hydroxypyrene levels in coke oven workers], Zhonghua lao dong wei sheng zhi ye bing za zhi. 2004 Aug;22(4):245-9.
[PubMed 15355699]
Genetic polymorphism of mEH gene could be a susceptible biomarker in coke oven workers which was involved in the individual susceptibility on metabolism of PAHs.
acute coronary syndrome Martin D Jarvis , et al. Clinical and experimental pharmacology & physiology 2009 Jul, CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients., Clinical and experimental pharmacology & physiology 2009 Jul.
[PubMed 19650794]
adenocarcinoma of the lung Taioli E et al. 1995, A specific African-American CYP1A1 polymorphism is associated with adenocarcinoma of the lung., Cancer research. 1995 Feb;55(3):472-3.
[PubMed 7834609]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A4F3V9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.