Human Gene APOBR (uc010byg.2)
  Description: Homo sapiens apolipoprotein B receptor (APOBR), mRNA.
RefSeq Summary (NM_018690): Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Transcript (Including UTRs)
   Position: hg19 chr16:28,505,970-28,510,291 Size: 4,322 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr16:28,507,776-28,509,826 Size: 2,051 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:28,505,970-28,510,291)mRNA (may differ from genome)Protein (626 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: H3BU97_HUMAN
DESCRIPTION: SubName: Full=Apolipoprotein B receptor;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 123.79 RPKM in Whole Blood
Total median expression: 322.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -510.321214-0.420 Picture PostScript Text
3' UTR -172.40465-0.371 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026158 - ApolipoprotB_rcpt

ModBase Predicted Comparative 3D Structure on H3BU97
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  JD437967 - Sequence 418991 from Patent EP1572962.
BC119786 - Homo sapiens apolipoprotein B48 receptor, mRNA (cDNA clone MGC:134647 IMAGE:40008686), complete cds.
BC119788 - Homo sapiens apolipoprotein B48 receptor, mRNA (cDNA clone MGC:134646 IMAGE:40008685), complete cds.
AF141332 - Homo sapiens apolipoprotein B48 receptor (APOB48R) mRNA, complete cds.
AF141334 - Homo sapiens placenta apolipoprotein B48 receptor type 2 (APOB48R) mRNA, complete cds.
JD316729 - Sequence 297753 from Patent EP1572962.
KJ899216 - Synthetic construct Homo sapiens clone ccsbBroadEn_08610 APOBR gene, encodes complete protein.
AK025123 - Homo sapiens cDNA: FLJ21470 fis, clone COL04907, highly similar to AF141332 Homo sapiens apolipoprotein B48 receptor (APOB48R) mRNA.
DQ580892 - Homo sapiens piRNA piR-49004, complete sequence.
AK075085 - Homo sapiens cDNA FLJ90604 fis, clone PLACE1001516.
DQ588671 - Homo sapiens piRNA piR-55783, complete sequence.
JD102781 - Sequence 83805 from Patent EP1572962.
JD213861 - Sequence 194885 from Patent EP1572962.
JD464003 - Sequence 445027 from Patent EP1572962.
JD421131 - Sequence 402155 from Patent EP1572962.
JD532376 - Sequence 513400 from Patent EP1572962.
JD443303 - Sequence 424327 from Patent EP1572962.
JD061201 - Sequence 42225 from Patent EP1572962.
JD111699 - Sequence 92723 from Patent EP1572962.
JD254252 - Sequence 235276 from Patent EP1572962.
JD099345 - Sequence 80369 from Patent EP1572962.
JD072637 - Sequence 53661 from Patent EP1572962.
JD534010 - Sequence 515034 from Patent EP1572962.
JD057922 - Sequence 38946 from Patent EP1572962.
JD362368 - Sequence 343392 from Patent EP1572962.
JD430832 - Sequence 411856 from Patent EP1572962.
JD430833 - Sequence 411857 from Patent EP1572962.
JD430834 - Sequence 411858 from Patent EP1572962.
JD430835 - Sequence 411859 from Patent EP1572962.
JD558387 - Sequence 539411 from Patent EP1572962.
JD558388 - Sequence 539412 from Patent EP1572962.
JD558389 - Sequence 539413 from Patent EP1572962.
JD556470 - Sequence 537494 from Patent EP1572962.
JD556471 - Sequence 537495 from Patent EP1572962.
JD441471 - Sequence 422495 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC119788, H3BU97, H3BU97_HUMAN
UCSC ID: uc010byg.2
RefSeq Accession: NM_018690
Protein: H3BU97

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC119788.1
exon count: 5CDS single in 3' UTR: no RNA size: 3209
ORF size: 1881CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 3119.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.