Description: Homo sapiens increased sodium tolerance 1 homolog (yeast) (IST1), transcript variant 3, mRNA. RefSeq Summary (NM_001270976): This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]. Transcript (Including UTRs) Position: hg19 chr16:71,928,311-71,964,540 Size: 36,230 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr16:71,928,738-71,961,716 Size: 32,979 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03398 - Regulator of Vps4 activity in the MVB pathway
ModBase Predicted Comparative 3D Structure on A8KAH5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
