Description: Homo sapiens C-type lectin domain family 10, member A (CLEC10A), transcript variant 2, mRNA. RefSeq Summary (NM_006344): This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:6,978,114-6,983,600 Size: 5,487 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr17:6,978,873-6,982,131 Size: 3,259 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IUN9-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC039011 - Homo sapiens C-type lectin domain family 10, member A, mRNA (cDNA clone MGC:47699 IMAGE:5751735), complete cds. BC027858 - Homo sapiens C-type lectin domain family 10, member A, mRNA (cDNA clone MGC:34439 IMAGE:5225381), complete cds. D50532 - Homo sapiens mRNA for macrophage lectin 2, complete cds. JD313164 - Sequence 294188 from Patent EP1572962. JD304366 - Sequence 285390 from Patent EP1572962. JD056287 - Sequence 37311 from Patent EP1572962. JD172726 - Sequence 153750 from Patent EP1572962. JD439018 - Sequence 420042 from Patent EP1572962. JD104113 - Sequence 85137 from Patent EP1572962. CU691636 - Synthetic construct Homo sapiens gateway clone IMAGE:100020797 5' read CLEC10A mRNA. KJ898219 - Synthetic construct Homo sapiens clone ccsbBroadEn_07613 CLEC10A gene, encodes complete protein. AK291975 - Homo sapiens cDNA FLJ78539 complete cds, highly similar to Homo sapiens C-type lectin domain family 10, member A, mRNA. AK292363 - Homo sapiens cDNA FLJ75226 complete cds, highly similar to Homo sapiens C-type lectin domain family 10, member A, mRNA. KJ902110 - Synthetic construct Homo sapiens clone ccsbBroadEn_11504 CLEC10A gene, encodes complete protein. JD103496 - Sequence 84520 from Patent EP1572962. JD322166 - Sequence 303190 from Patent EP1572962. JD370610 - Sequence 351634 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8IUN9 (Reactome details) participates in the following event(s):