Human Gene TP53 (uc010cne.1)
  Description: Homo sapiens tumor protein p53 (TP53), transcript variant 5, mRNA.
RefSeq Summary (NM_001126115): This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].
Transcript (Including UTRs)
   Position: hg19 chr17:7,571,720-7,576,926 Size: 5,207 Total Exon Count: 2 Strand: -


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA DescriptionsPathwaysOther Names
GeneReviewsModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:7,571,720-7,576,926)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerH-INVHGNCLynxMalacards
PubMed

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TP53
CDC HuGE Published Literature: TP53
Positive Disease Associations: aggressive behavior of chondrosarcoma , albuminuria among aboriginal Australians , alpha-particle carcinogenesis , betel-quid chewing , bladder cancer , Brain Neoplasms|Glioblastoma , brain tumors , breast cancer , breast cancer by the age of 50 years , breast cancer survival , breast carcinoma , cerebral infarct, atherothrombotic , cervical cancer , cervical cancer ovarian cancer , Cervical Intraepithelial Neoplasia|Cervical Neoplasm|Uterine Cervical Neoplasms , Cervical Intraepithelial Neoplasia|Papillomavirus Infections , chronic obstructive pulmonary disease/COPD , colorectal adenocarcinomas , colorectal cancer , colorectal cancers , decreased chemosensitivity , DNA Damage|Lung Neoplasms , endometrial cancer , esophageal cancer , gastric cancer , gastritis, chronic atrophic; stomach cancer , Glioblastoma , Head and neck squamous cell cancer , hepatitis C virus infection , increased aggressiveness , increased lung cancer risk , keloid , Leukemia, Lymphocytic, Chronic, B-Cell , Leukemia, Myeloid, Acute , liver cancer , Lung cancer , lung cancer; esophageal cancer , Lymphoma, Large B-Cell, Diffuse , malignant cystosarcoma phyllodes and soft tissue sarcoma , malignant myeloid disorders , metastases , metastatic progression and poor survival , mucosa-associated lymphoid tissue lymphoma , Neoplasms , non-small cell lung cancer , non-small cell lung carcinoma , oesophageal squamous cell carcinoma , ovarian cancer , ovarian carcinoma , pancreatic adenocarcinoma , progression of a prostate carcinoma , prostate cancer , psoriatic arthritis , ring sideroblasts , sensitivity to TZT-1027 , skin carcinomas , smoking , soft tissue sarcoma , squamous cell carcinoma , stomach cancer , tumor progression of BCR/ABL negative chronic myeloproliferative disorders , tumor proliferation and other prognostic indicators , tumour progression , ulcerative colitis , Xeroderma pigmentosum
Related Studies:
  1. aggressive behavior of chondrosarcoma
    Oshiro Y et al. 1998, Altered p53 is associated with aggressive behavior of chondrosarcoma: a long term follow-up study., Cancer. 1998 Dec;83(11):2324-34. [PubMed 9840532]
    Overexpression or alteration of the p53 gene is an important predictor of aggressive clinical behavior in chondrosarcoma of bone.
  2. albuminuria among aboriginal Australians
    McDonald SP et al. 2002, The p53Pro72Arg polymorphism is associated with albuminuria among aboriginal Australians., Journal of the American Society of Nephrology. 2002 Mar;13(3):677-83. [PubMed 11856771]
  3. alpha-particle carcinogenesis
    Wada I et al. 1999, High rate of small TP53 mutations and infrequent loss of heterozygosity in malignant liver tumors associated with thorotrast: implications for alpha-particle carcinogenesis., Radiation research. 1999 Dec;152(6 Suppl):S125-7. [PubMed 10564952]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: TP53
Diseases sorted by gene-association score: li-fraumeni syndrome* (1762), osteosarcoma, somatic* (1275), choroid plexus papilloma* (1255), adrenal cortical carcinoma* (957), pancreatic cancer* (761), basal cell carcinoma 7* (594), nasopharyngeal carcinoma* (515), hepatocellular carcinoma* (483), choroid plexus cancer* (422), glioma susceptibility 1* (332), breast cancer* (315), small cell cancer of the lung, somatic* (264), megakaryocytic leukemia* (231), chronic lymphocytic leukemia* (216), brca1 hereditary breast and ovarian cancer syndrome* (163), colorectal cancer* (159), brca2 hereditary breast and ovarian cancer syndrome* (141), adenocarcinoma (48), malignant glioma (37), squamous cell carcinoma (35), grade iii astrocytoma (35), papilloma (32), bladder urothelial carcinoma (31), penile cancer (30), cervical cancer, somatic (26), transitional cell carcinoma (25), actinic keratosis (25), serous cystadenocarcinoma (25), bile duct carcinoma (24), barrett's adenocarcinoma (24), basal cell carcinoma (24), brain glioma (24), uterine corpus cancer (23), cervix carcinoma (23), lung cancer (23), skin squamous cell carcinoma (23), intestinal disease (23), bladder transitional cell papilloma (23), conjunctival squamous cell carcinoma (22), xanthogranulomatous cholecystitis (22), papilledema (22), thyroid lymphoma (21), multifocal osteogenic sarcoma (21), glioblastoma multiforme (21), breast ductal carcinoma (21), cell type cancer (20), oral cancer (19), gastroesophageal reflux (19), vulvar intraepithelial neoplasia (18), actinic cheilitis (18), esophageal cancer (18), b cell prolymphocytic leukemia (18), hepadnavirus infection (18), ovary epithelial cancer (17), malignant ovarian surface epithelial-stromal neoplasm (17), atrophy of prostate (17), verrucous carcinoma (17), basaloid squamous cell carcinoma (17), ovarian serous carcinoma (17), endometrial cancer (17), mixed cell type cancer (16), fallopian tube carcinoma (16), cheilitis (16), urinary bladder cancer (16), cll/sll (16), astrocytoma (16), anal squamous cell carcinoma (15), necrotizing sialometaplasia (15), mature teratoma (15), ulcerative stomatitis (15), invasive bladder transitional cell carcinoma (15), hereditary breast ovarian cancer* (15), kidney cancer (14), vulvar sebaceous carcinoma (14), blastoma (14), endometrial adenocarcinoma (14), cystadenocarcinoma (14), bladder cancer, somatic (14), pleomorphic xanthoastrocytoma (14), richter's syndrome (14), larynx cancer (14), in situ carcinoma (14), gallbladder cancer (14), lung occult squamous cell carcinoma (14), clivus meningioma (14), mixed astrocytoma-ependymoma (14), giant cell glioblastoma* (14), parietal lobe neoplasm (14), spinal cord primitive neuroectodermal neoplasm (14), mixed oligodendroglioma-astrocytoma (14), penis carcinoma in situ (14), submandibular gland cancer (14), parameningeal embryonal rhabdomyosarcoma (14), central nervous system lymphoma (13), oral squamous cell carcinoma (13), clear cell cystadenofibroma (13), plantar wart (13), keratocystic odontogenic tumor (13), pleuropulmonary blastoma (13), pulmonary blastoma (13), balkan nephropathy (13), lung benign neoplasm (13), essential thrombocythemia* (13), esophageal basaloid squamous cell carcinoma (13), vulva cancer (13), pancreatic ductal adenocarcinoma (13), scrotal carcinoma (13), adult hepatocellular carcinoma* (12), gliomatosis cerebri (12), familial adenomatous polyposis (12), inverted papilloma (12), gastric lymphoma (12), lip cancer (12), ataxia-telangiectasia (12), stomach cancer (12), breast carcinoma in situ (12), ovarian cancer, somatic (12), tongue squamous cell carcinoma (12), gastrointestinal system benign neoplasm (12), uterine carcinosarcoma (11), mixed glioma (11), ductal carcinoma in situ (11), gastrointestinal system cancer (11), colorectal adenocarcinoma (11), uterine corpus serous adenocarcinoma (11), acinar cell carcinoma (11), maxillary sinus squamous cell carcinoma (11), microglandular adenosis (11), vulva squamous cell carcinoma (11), barrett esophagus/esophageal adenocarcinoma (11), female reproductive endometrioid cancer (11), cerebellum cancer (11), pleomorphic carcinoma (11), gliosarcoma* (11), breast adenocarcinoma (11), cerebellar astrocytoma (11), cell type benign neoplasm (11), chordoid glioma (11), nevus of ota (10), glioma (10), bone giant cell sarcoma (10), brain cancer (10), gliofibroma (10), squamous cell carcinoma, head and neck (10), cystic teratoma (10), ring chromosome 7 (10), fibrillary astrocytoma (10), cholecystitis (10), glioblastoma (10), endocervical adenocarcinoma (10), colorectal adenoma (10), glomangiosarcoma (10), cellular neurofibroma (10), endometrium carcinoma in situ (10), myasthenic syndrome, congenital, 17 (10), soft tissue sarcoma (10), myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects (9), keratoacanthoma (9), frontal convexity meningioma (9), cerebellar angioblastoma (9), kaposi sarcoma (9), larynx verrucous carcinoma (9), epidermal appendage tumor (9), splenic diffuse red pulp small b-cell lymphoma (9), mucoepidermoid esophageal carcinoma (9), esophagus adenocarcinoma (9), lichen sclerosus (9), sarcoma (9), rhabdomyosarcoma (9), esophagitis (9), granulosa cell tumor of the ovary (9), intrahepatic cholangiocarcinoma (9), spitz nevus (9), integumentary system cancer (9), bladder papillary transitional cell neoplasm (9), urinary tract papillary transitional cell benign neoplasm (9), skin melanoma (9), breast malignant phyllodes tumor (9), primary peritoneal carcinoma (9), small cell neuroendocrine carcinoma (9), ovarian clear cell carcinoma (9), hidradenocarcinoma (9), spiradenoma (9), cervical adenocarcinoma (9), sporadic breast cancer (9), b-cell lymphomas (9), non-invasive bladder papillary urothelial neoplasm (9), pre-malignant neoplasm (9), pleomorphic rhabdomyosarcoma (9), embryonal sarcoma (9), pleomorphic adenoma carcinoma (9), female breast cancer (9), pancreatic ductal carcinoma (8), ganglioglioma (8), tongue cancer (8), oral leukoplakia (8), brooke-spiegler syndrome (8), bile duct adenocarcinoma (8), pigmented villonodular synovitis (8), meninges sarcoma (8), xeroderma pigmentosum, variant type (8), calcifying epithelial odontogenic tumor (8), malignant spiradenoma (8), biliary tract neoplasm (8), lung cancer susceptibility 3 (8), bartholin's duct cyst (8), intracranial chondrosarcoma (8), marek disease (8), penis squamous cell carcinoma (8), ovary adenocarcinoma (8), brain ependymoma (8), tetraploidy (8), short-rib thoracic dysplasia 4 with or without polydactyly (8), female reproductive organ cancer (8), retinal cancer (8), sensory system cancer (8), mantle cell lymphoma (8), vestibular gland benign neoplasm (8), endometrial clear cell adenocarcinoma (8), bartholin's gland adenoma (8), adult t-cell leukemia (8), brain stem astrocytic neoplasm (8), peutz-jeghers syndrome (8), medulloblastoma (7), glomus tumor (7), uterine body mixed cancer (7), histiocytoma (7), nijmegen breakage syndrome (7), xeroderma pigmentosum, group a (7), oligodendroglioma (7), dedifferentiated liposarcoma (7), nervous system cancer (7), liposarcoma (7), retinoblastoma (7), mutyh-associated polyposis (7), adenosquamous carcinoma (7), hyperplastic polyposis syndrome (7), supratentorial cancer (7), infratentorial cancer (7), pseudomyxoma peritonei (7), protoplasmic astrocytoma (7), small cell carcinoma (7), reproductive organ cancer (7), bladder carcinoma in situ (7), lung squamous cell carcinoma (7), brain stem cancer (7), estrogen-receptor positive breast cancer (7), rift valley fever (7), myxoid liposarcoma (7), pharynx cancer (7), clear cell adenocarcinoma (7), mucinous adenocarcinoma (7), papillary glioneuronal tumor (7), sweat gland cancer (7), sapho syndrome (7), merkel cell carcinoma (7), connective tissue cancer (7), eccrine sweat gland neoplasm (7), cervical squamous cell carcinoma (7), mutagen sensitivity (7), cerebrum cancer (7), gastrointestinal carcinoma (7), autonomic nervous system neoplasm (7), spinal cord astrocytoma (7), gastric cardia adenocarcinoma (6), diffuse large b-cell lymphoma (6), oropharynx cancer (6), lung papillary adenocarcinoma (6), papillary serous adenocarcinoma (6), adamantinoma of long bones (6), malignant giant cell tumor (6), lymph node cancer (6), brain stem glioma (6), rectal neoplasm (6), cerebral neuroblastoma (6), achalasia (6), lynch syndrome (6), brain glioblastoma multiforme (6), cervix uteri carcinoma in situ (6), thymus cancer (6), angiosarcoma (6), malignant ependymoma (6), uterine corpus endometrial carcinoma (6), peripheral nervous system neoplasm (6), bizarre leiomyoma (6), keratosis (6), lichen planus (6), cerebral convexity meningioma (6), pleomorphic adenoma (6), keratinizing squamous cell carcinoma (6), prostate adenocarcinoma (6), intestinal benign neoplasm (6), leiomyosarcoma (6), malignant fibroxanthoma (6), teratoma (6), cerebral ventricle cancer (6), dermatofibrosarcoma protuberans (6), atrophic gastritis (6), leukemia, acute lymphoblastic 3* (6), thyroid cancer (6), melanoma (6), breast disease (6), ependymoblastoma (6), central nervous system primitive neuroectodermal neoplasm (6), biliary papillomatosis (6), acute lymphocytic leukemia (6), esophageal disease (6), breast benign neoplasm (6), thoracic benign neoplasm (6), spinal cancer (6), prolactin producing pituitary tumor (6), testicular germ cell tumor (6), ureteral obstruction (6), adenoma (6), cervical carcinosarcoma (5), hypoxia (5), lip disease (5), prostate cancer (5), sarcomatoid squamous cell skin carcinoma (5), ocular cancer (5), fallopian tube adenocarcinoma (5), bartholin's gland benign neoplasm (5), squamous cell papilloma (5), inflammatory myofibroblastic tumor (5), malignant peripheral nerve sheath tumor (5), nervous system benign neoplasm (5), male reproductive organ cancer (5), endometrial stromal sarcoma (5), clear cell renal cell carcinoma (5), organ system benign neoplasm (5), central nervous system organ benign neoplasm (5), muscle cancer (5), myxosarcoma (5), endocervical carcinoma (5), olfactory groove meningioma (5), atypical follicular adenoma (5), childhood leukemia (5), nasal cavity adenocarcinoma (5), pancreas adenocarcinoma (5), synchronous bilateral breast carcinoma (5), cataract 24, anterior polar (5), sclerosing liposarcoma (5), glycogen-rich clear cell breast carcinoma (5), hydrocephalus (5), anogenital venereal wart (5), juvenile pilocytic astrocytoma (5), familial colorectal cancer (5), tonsil cancer (5), non-proliferative fibrocystic change of the breast (5), epidural neoplasm (5), gastric cancer, somatic (5), multiple cranial nerve palsy (4), anterior cranial fossa meningioma (4), ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (4), meningeal melanomatosis (4), liver angiosarcoma (4), bone squamous cell carcinoma (4), duodenum cancer (4), signet ring cell adenocarcinoma (4), clear cell ependymoma (4), cervix small cell carcinoma (4), breast metaplastic carcinoma (4), mature b-cell neoplasm (4), cerebral primitive neuroectodermal tumor (4), agraphia (4), lichen disease (4), periosteal osteogenic sarcoma (4), adult medulloblastoma (4), small cell sarcoma (4), cellular schwannoma (4), chronic salpingitis (4), bladder squamous cell carcinoma (4), cribriform carcinoma (4), conjunctival degeneration (4), localized osteosarcoma (4), chromophobe adenoma (4), medullomyoblastoma (4), malignant mesenchymoma (4), cerebellar liponeurocytoma (3), optic nerve neoplasm (3), split-hand/foot malformation 4 (3), huntington disease (3), pinguecula (3), optic nerve glioma (3), vaccinia (3), malignant melanoma, somatic (3), differentiated thyroid carcinoma (3), mucoepidermoid carcinoma (3), cystitis (3), chordoma (3), gastrointestinal stromal tumor (2), acquired immunodeficiency syndrome (2), multiple myeloma (2), aplastic anemia (2), uveal melanoma (2), ewing sarcoma (2), endocrine gland cancer (2), neuroblastoma (2), autosomal genetic disease (2), germ cell and embryonal cancer (1), meningioma, familial (1), leukemia, acute myeloid (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.06 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 470.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  EF101868 - Homo sapiens cell-line L1236 nonfunctional tumor suppressor p53 (TP53) mRNA, complete cds.
AM076972 - Homo sapiens partial mRNA for tumor protein p53 mutant form (TP53 gene), classical Hodgkin Lymphoma cell line L1236.
DQ186650 - Homo sapiens del133 p53 isoform (TP53) mRNA, complete cds.
DQ186651 - Homo sapiens del133 p53 beta isoform (TP53) mRNA, complete cds.
DQ186652 - Homo sapiens del133 p53 gamma isoform (TP53) mRNA, complete cds.
HW061196 - JP 2012529430-A/71: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061197 - JP 2012529430-A/72: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061198 - JP 2012529430-A/73: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482151 - Sequence 134 from Patent WO2011072091.
JA482152 - Sequence 135 from Patent WO2011072091.
JA482153 - Sequence 136 from Patent WO2011072091.
JB252004 - Sequence 71 from Patent EP2440214.
JB252005 - Sequence 72 from Patent EP2440214.
JB252006 - Sequence 73 from Patent EP2440214.
JE980443 - Sequence 134 from Patent EP2862929.
JE980444 - Sequence 135 from Patent EP2862929.
JE980445 - Sequence 136 from Patent EP2862929.
LP764903 - Sequence 71 from Patent EP3276004.
LP764904 - Sequence 72 from Patent EP3276004.
LP764905 - Sequence 73 from Patent EP3276004.
JN900492 - Homo sapiens tumor suppressor TP53 (TP53) mRNA, complete cds, alternatively spliced.
HW061192 - JP 2012529430-A/67: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061193 - JP 2012529430-A/68: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061194 - JP 2012529430-A/69: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061195 - JP 2012529430-A/70: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482147 - Sequence 130 from Patent WO2011072091.
JA482148 - Sequence 131 from Patent WO2011072091.
JA482149 - Sequence 132 from Patent WO2011072091.
JA482150 - Sequence 133 from Patent WO2011072091.
JB252000 - Sequence 67 from Patent EP2440214.
JB252001 - Sequence 68 from Patent EP2440214.
JB252002 - Sequence 69 from Patent EP2440214.
JB252003 - Sequence 70 from Patent EP2440214.
JE980439 - Sequence 130 from Patent EP2862929.
JE980440 - Sequence 131 from Patent EP2862929.
JE980441 - Sequence 132 from Patent EP2862929.
JE980442 - Sequence 133 from Patent EP2862929.
LP764899 - Sequence 67 from Patent EP3276004.
LP764900 - Sequence 68 from Patent EP3276004.
LP764901 - Sequence 69 from Patent EP3276004.
LP764902 - Sequence 70 from Patent EP3276004.
LY486121 - KR 1020170007492-A/1: METHODS AND COMPOSITIONS FOR PREVENTING ISCHEMIA REPERFUSION INJURY IN ORGANS.
LZ228280 - JP 2017521374-A/1: METHODS AND COMPOSITIONS FOR PREVENTING ISCHEMIA REPERFUSION INJURY IN ORGANS.
DM163612 - Method for promotion of p53 expression.
HV708907 - JP 2012506450-A/5: Methods for treating eye disorders.
DQ186648 - Homo sapiens p53 beta isoform (TP53) mRNA, complete cds.
DQ186649 - Homo sapiens p53 gamma isoform (TP53) mRNA, complete cds.
DQ286964 - Homo sapiens p53 protein (TP53) mRNA, complete cds, alternatively spliced.
DQ191317 - Homo sapiens p53 protein (TP53) mRNA, complete cds, alternatively spliced.
AF052180 - Homo sapiens clone 24564 mRNA sequence.
AK223026 - Homo sapiens mRNA for tumor protein p53 variant, clone: JTH07296.
X01405 - Human mRNA fragment for phosphoprotein p53.
AB082923 - Homo sapiens mRNA for P53, complete cds.
BC003596 - Homo sapiens tumor protein p53, mRNA (cDNA clone MGC:646 IMAGE:3544714), complete cds.
AF307851 - Homo sapiens p53 protein mRNA, complete cds.
JN214348 - Homo sapiens cell-line HCT116p53-/- nonfunctional delta40-P53 transcript variant (TP53) mRNA, complete sequence.
FJ207420 - Homo sapiens mutant p53 mRNA, complete cds.
JD123340 - Sequence 104364 from Patent EP1572962.
JD299783 - Sequence 280807 from Patent EP1572962.
JD378958 - Sequence 359982 from Patent EP1572962.
JD533970 - Sequence 514994 from Patent EP1572962.
JD321581 - Sequence 302605 from Patent EP1572962.
JD064504 - Sequence 45528 from Patent EP1572962.
JD295458 - Sequence 276482 from Patent EP1572962.
JD333220 - Sequence 314244 from Patent EP1572962.
JD071890 - Sequence 52914 from Patent EP1572962.
JD398255 - Sequence 379279 from Patent EP1572962.
JD286216 - Sequence 267240 from Patent EP1572962.
JD480909 - Sequence 461933 from Patent EP1572962.
JD543982 - Sequence 525006 from Patent EP1572962.
JD542311 - Sequence 523335 from Patent EP1572962.
JD293418 - Sequence 274442 from Patent EP1572962.
JD562184 - Sequence 543208 from Patent EP1572962.
JD432939 - Sequence 413963 from Patent EP1572962.
JD457509 - Sequence 438533 from Patent EP1572962.
JD202361 - Sequence 183385 from Patent EP1572962.
JD141194 - Sequence 122218 from Patent EP1572962.
JD266224 - Sequence 247248 from Patent EP1572962.
JD564555 - Sequence 545579 from Patent EP1572962.
JD566766 - Sequence 547790 from Patent EP1572962.
JD266223 - Sequence 247247 from Patent EP1572962.
JD297255 - Sequence 278279 from Patent EP1572962.
JD393077 - Sequence 374101 from Patent EP1572962.
JD486665 - Sequence 467689 from Patent EP1572962.
AK297927 - Homo sapiens cDNA FLJ54299 complete cds, highly similar to Cellular tumor antigen p53.
AK297462 - Homo sapiens cDNA FLJ54297 complete cds, highly similar to Cellular tumor antigen p53.
JD168340 - Sequence 149364 from Patent EP1572962.
JD527824 - Sequence 508848 from Patent EP1572962.
K03199 - Human p53 cellular tumor antigen mRNA, complete cds.
AK225838 - Homo sapiens mRNA for Cellular tumor antigen p53 variant, clone: FCC127A11.
JD298986 - Sequence 280010 from Patent EP1572962.
JD168621 - Sequence 149645 from Patent EP1572962.
JQ694049 - Homo sapiens isolate iPCH358_Col1 tumor suppressor p53 (TP53) mRNA, complete cds.
JQ694050 - Homo sapiens isolate iPCH358_Col3 tumor suppressor p53 (TP53) mRNA, complete cds.
JQ694051 - Homo sapiens isolate iPCH358_Col11 tumor suppressor p53 (TP53) mRNA, complete cds.
JD317542 - Sequence 298566 from Patent EP1572962.
JD059195 - Sequence 40219 from Patent EP1572962.
DQ648886 - Homo sapiens p53+ins9a (TP53) mRNA, 3' UTR, alternatively spliced.
DQ648887 - Homo sapiens p53-Ex10 isoform (TP53) mRNA, partial cds, alternatively spliced.
JQ026208 - Homo sapiens clone c.398-399ins4 mutated tumor suppressor protein P53 mRNA sequence.
JD477257 - Sequence 458281 from Patent EP1572962.
JQ026207 - Homo sapiens clone c.159del1 mutated tumor suppressor protein P53 mRNA sequence.
AM076970 - Homo sapiens partial mRNA for tumor protein p53 mutant form (TP53 gene), classical Hodgkin Lymphoma cell line L428.
DQ263704 - Homo sapiens tumor protein p53 (TP53) mRNA, complete cds.
EF101867 - Homo sapiens cell-line L428 nonfunctional tumor suppressor p53 (TP53) mRNA, complete cds.
JN601513 - Homo sapiens isolate MV4-11 mutant p53 protein mRNA, partial cds.
JN601514 - Homo sapiens isolate Kasumi-1 mutant p53 protein mRNA, partial cds.
JN601515 - Homo sapiens isolate CMS mutant p53 protein mRNA, partial cds.
JN601516 - Homo sapiens isolate THP-1 truncated p53 protein mRNA, partial cds.
JQ026210 - Homo sapiens clone c.792_796del5 mutated tumor suppressor protein P53 mRNA sequence.
MG595979 - Homo sapiens isolate TWH-1414-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595980 - Homo sapiens isolate TWH-0571-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595981 - Homo sapiens isolate TWH-0357-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595982 - Homo sapiens isolate TWH-1016-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595983 - Homo sapiens isolate HKSH-0023-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595984 - Homo sapiens isolate PMH-0020-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595985 - Homo sapiens isolate TWH-0863-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595986 - Homo sapiens isolate TWH-1542-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595987 - Homo sapiens isolate TWH-0104-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595988 - Homo sapiens isolate HKSH-0182-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595989 - Homo sapiens isolate TWH-0855-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595990 - Homo sapiens isolate KWH-0019-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595991 - Homo sapiens isolate TWH-1681-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595992 - Homo sapiens isolate TWH-0602-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595993 - Homo sapiens isolate TWH-0395-0-1 truncated tumor protein p53 (TP53) mRNA, complete cds.
MG595994 - Homo sapiens isolate TWH-1698-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
M14695 - Human p53 cellular tumor antigen mRNA, complete cds.
M14694 - Human p53 cellular tumor antigen mRNA, complete cds.
X02469 - Human mRNA for p53 cellular tumor antigen.
AK312568 - Homo sapiens cDNA, FLJ92943, Homo sapiens tumor protein p53 (Li-Fraumeni syndrome) (TP53), mRNA.
KJ897694 - Synthetic construct Homo sapiens clone ccsbBroadEn_07088 TP53 gene, encodes complete protein.
KR709864 - Synthetic construct Homo sapiens clone CCSBHm_00006902 TP53 (TP53) mRNA, encodes complete protein.
KR709865 - Synthetic construct Homo sapiens clone CCSBHm_00006929 TP53 (TP53) mRNA, encodes complete protein.
KR709866 - Synthetic construct Homo sapiens clone CCSBHm_00006983 TP53 (TP53) mRNA, encodes complete protein.
KR709867 - Synthetic construct Homo sapiens clone CCSBHm_00007040 TP53 (TP53) mRNA, encodes complete protein.
BT019622 - Homo sapiens tumor protein p53 (Li-Fraumeni syndrome) mRNA, complete cds.
DQ892492 - Synthetic construct clone IMAGE:100005122; FLH186809.01X; RZPDo839A0972D tumor protein p53 (Li-Fraumeni syndrome) (TP53) gene, encodes complete protein.
DQ895704 - Synthetic construct Homo sapiens clone IMAGE:100010164; FLH186805.01L; RZPDo839A0962D tumor protein p53 (Li-Fraumeni syndrome) (TP53) gene, encodes complete protein.
X60011 - Human mRNA for mutated p53 transformation suppressor gene.
X60012 - Human mRNA for mutated p53 transformation suppressor gene.
X60013 - Human mRNA for mutated p53 transformation suppressor gene.
X60014 - Human mRNA for mutated p53 transformation suppressor gene.
X60015 - Human mRNA for mutated p53 transformation suppressor gene.
X60016 - Human mRNA for mutated p53 transformation suppressor gene.
X60017 - Human mRNA for mutated p53 transformation suppressor gene.
X60018 - Human mRNA for mutated p53 transformation suppressor gene.
X60019 - Human mRNA for mutated p53 transformation suppressor gene.
X60020 - Human mRNA for mutated p53 transformation suppressor gene.
AB527267 - Synthetic construct DNA, clone: pF1KB8730, Homo sapiens TP53 gene for tumor protein p53, without stop codon, in Flexi system.
JQ026209 - Homo sapiens clone c.672_673ins5 mutated tumor suppressor protein P53 mRNA sequence.
LP866503 - Sequence 57 from Patent WO2017162888.
AY429684 - Homo sapiens tumor suppressor p53 (TP53) mRNA, partial cds.
S66666 - p53=tumor suppressor {alternatively spliced, exon 9-10} [human, Molt-4, T-lymphoblastic leukemia cell line, mRNA PartialMutant, 160 nt].
DL476249 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
DL476265 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941369 - JP 2012152216-A/194: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HV941385 - JP 2012152216-A/210: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798275 - JP 2014236738-A/194: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798291 - JP 2014236738-A/210: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476266 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941386 - JP 2012152216-A/211: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798292 - JP 2014236738-A/211: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
KY907121 - Homo sapiens isolate CC2_TP53 p53 (TP53) mRNA, partial cds.
KY907122 - Homo sapiens isolate CC3_TP53 p53 (TP53) mRNA, partial cds.
KY907123 - Homo sapiens isolate CC5_TP53 p53 (TP53) mRNA, partial cds.
KY907124 - Homo sapiens isolate CC7_TP53 p53 (TP53) mRNA, partial cds.
KY907125 - Homo sapiens isolate CC10_TP53 p53 (TP53) mRNA, partial cds.
KY907126 - Homo sapiens isolate CC11_TP53 p53 (TP53) mRNA, partial cds.
KY907127 - Homo sapiens isolate CC12_TP53 p53 (TP53) mRNA, partial cds.
KY907128 - Homo sapiens isolate CC15_TP53 p53 (TP53) mRNA, partial cds.
KY907129 - Homo sapiens isolate CC17_TP53 p53 (TP53) mRNA, partial cds.
KY907130 - Homo sapiens isolate CC19_TP53 p53 (TP53) mRNA, partial cds.
KY907131 - Homo sapiens isolate CC20_TP53 p53 (TP53) mRNA, partial cds.
KY907132 - Homo sapiens isolate CC21_TP53 p53 (TP53) mRNA, partial cds.
KY907133 - Homo sapiens isolate CC22_TP53 p53 (TP53) mRNA, partial cds.
KY907134 - Homo sapiens isolate CC23_TP53 p53 (TP53) mRNA, partial cds.
KY907135 - Homo sapiens isolate CC24_TP53 p53 (TP53) mRNA, partial cds.
KY907136 - Homo sapiens isolate CC26_TP53 p53 (TP53) mRNA, partial cds.
KY907137 - Homo sapiens isolate CC27_TP53 p53 (TP53) mRNA, partial cds.
KY907138 - Homo sapiens isolate CC28_TP53 p53 (TP53) mRNA, partial cds.
KY907139 - Homo sapiens isolate CC29_TP53 p53 (TP53) mRNA, partial cds.
KY907140 - Homo sapiens isolate CC30_TP53 p53 (TP53) mRNA, partial cds.
KY907141 - Homo sapiens isolate CC33_TP53 p53 (TP53) mRNA, partial cds.
KY907142 - Homo sapiens isolate CC34_TP53 p53 (TP53) mRNA, partial cds.
KY907143 - Homo sapiens isolate CC35_TP53 p53 (TP53) mRNA, partial cds.
KY907144 - Homo sapiens isolate CC36_TP53 p53 (TP53) mRNA, partial cds.
KY907145 - Homo sapiens isolate CC37_TP53 p53 (TP53) mRNA, partial cds.
KY907146 - Homo sapiens isolate CC38_TP53 p53 (TP53) mRNA, partial cds.
DL476283 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941403 - JP 2012152216-A/228: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798309 - JP 2014236738-A/228: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476292 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941412 - JP 2012152216-A/237: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798318 - JP 2014236738-A/237: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476274 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941394 - JP 2012152216-A/219: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798300 - JP 2014236738-A/219: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476250 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941370 - JP 2012152216-A/195: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798276 - JP 2014236738-A/195: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
LQ948588 - Sequence 5 from Patent WO2014043292.
LQ948589 - Sequence 6 from Patent WO2014043292.
LQ948590 - Sequence 7 from Patent WO2014043292.
LQ948584 - Sequence 1 from Patent WO2014043292.
LQ948585 - Sequence 2 from Patent WO2014043292.
LQ948586 - Sequence 3 from Patent WO2014043292.
LQ948587 - Sequence 4 from Patent WO2014043292.
MP140196 - Sequence 5 from Patent EP3444349.
MP140197 - Sequence 6 from Patent EP3444349.
MP140198 - Sequence 7 from Patent EP3444349.
MP140192 - Sequence 1 from Patent EP3444349.
MP140193 - Sequence 2 from Patent EP3444349.
MP140194 - Sequence 3 from Patent EP3444349.
MP140195 - Sequence 4 from Patent EP3444349.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04110 - Cell cycle
hsa04115 - p53 signaling pathway
hsa04210 - Apoptosis
hsa04310 - Wnt signaling pathway
hsa04722 - Neurotrophin signaling pathway
hsa05014 - Amyotrophic lateral sclerosis (ALS)
hsa05016 - Huntington's disease
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05212 - Pancreatic cancer
hsa05213 - Endometrial cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05216 - Thyroid cancer
hsa05217 - Basal cell carcinoma
hsa05218 - Melanoma
hsa05219 - Bladder cancer
hsa05220 - Chronic myeloid leukemia
hsa05222 - Small cell lung cancer
hsa05223 - Non-small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_atmPathway - ATM Signaling Pathway
h_telPathway - Telomeres, Telomerase, Cellular Aging, and Immortality
h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system
h_pmlPathway - Regulation of transcriptional activity by PML
h_btg2Pathway - BTG family proteins and cell cycle regulation
h_rbPathway - RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
h_rnaPathway - Double Stranded RNA Induced Gene Expression
h_tertpathway - Overview of telomerase protein component gene hTert Transcriptional Regulation
h_tidPathway - Chaperones modulate interferon Signaling Pathway
h_chemicalPathway - Apoptotic Signaling in Response to DNA Damage
h_plk3Pathway - Regulation of cell cycle progression by Plk3
h_ctcfPathway - CTCF: First Multivalent Nuclear Factor
h_EfpPathway - Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
h_atrbrcaPathway - Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility
h_g1Pathway - Cell Cycle: G1/S Check Point
h_arfPathway - Tumor Suppressor Arf Inhibits Ribosomal Biogenesis
h_g2Pathway - Cell Cycle: G2/M Checkpoint
h_p53Pathway - p53 Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: DQ648887
UCSC ID: uc010cne.1
RefSeq Accession: NM_001126115

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene TP53:
li-fraumeni (Li-Fraumeni Syndrome)
wilms-ov (Wilms Tumor Predisposition)

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: DQ648887.1
exon count: 2CDS single in 3' UTR: yes RNA size: 175
ORF size: 0CDS single in intron: no Alignment % ID: 99.43
txCdsPredict score: 624.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.