Human Gene TP53 (uc010cni.2)
  Description: Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA.
RefSeq Summary (NM_001276696): This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].
Transcript (Including UTRs)
   Position: hg19 chr17:7,571,720-7,590,868 Size: 19,149 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr17:7,576,625-7,579,912 Size: 3,288 Coding Exon Count: 9 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:7,571,720-7,590,868)mRNA (may differ from genome)Protein (302 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMalacardsMGIOMIMPubMed
ReactomeUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TP53
CDC HuGE Published Literature: TP53
Positive Disease Associations: aggressive behavior of chondrosarcoma , albuminuria among aboriginal Australians , alpha-particle carcinogenesis , betel-quid chewing , bladder cancer , Brain Neoplasms|Glioblastoma , brain tumors , breast cancer , breast cancer by the age of 50 years , breast cancer survival , breast carcinoma , cerebral infarct, atherothrombotic , cervical cancer , cervical cancer ovarian cancer , Cervical Intraepithelial Neoplasia|Cervical Neoplasm|Uterine Cervical Neoplasms , Cervical Intraepithelial Neoplasia|Papillomavirus Infections , chronic obstructive pulmonary disease/COPD , colorectal adenocarcinomas , colorectal cancer , colorectal cancers , decreased chemosensitivity , DNA Damage|Lung Neoplasms , endometrial cancer , esophageal cancer , gastric cancer , gastritis, chronic atrophic; stomach cancer , Glioblastoma , Head and neck squamous cell cancer , hepatitis C virus infection , increased aggressiveness , increased lung cancer risk , keloid , Leukemia, Lymphocytic, Chronic, B-Cell , Leukemia, Myeloid, Acute , liver cancer , Lung cancer , lung cancer; esophageal cancer , Lymphoma, Large B-Cell, Diffuse , malignant cystosarcoma phyllodes and soft tissue sarcoma , malignant myeloid disorders , metastases , metastatic progression and poor survival , mucosa-associated lymphoid tissue lymphoma , Neoplasms , non-small cell lung cancer , non-small cell lung carcinoma , oesophageal squamous cell carcinoma , ovarian cancer , ovarian carcinoma , pancreatic adenocarcinoma , progression of a prostate carcinoma , prostate cancer , psoriatic arthritis , ring sideroblasts , sensitivity to TZT-1027 , skin carcinomas , smoking , soft tissue sarcoma , squamous cell carcinoma , stomach cancer , tumor progression of BCR/ABL negative chronic myeloproliferative disorders , tumor proliferation and other prognostic indicators , tumour progression , ulcerative colitis , Xeroderma pigmentosum
Related Studies:
  1. aggressive behavior of chondrosarcoma
    Oshiro Y et al. 1998, Altered p53 is associated with aggressive behavior of chondrosarcoma: a long term follow-up study., Cancer. 1998 Dec;83(11):2324-34. [PubMed 9840532]
    Overexpression or alteration of the p53 gene is an important predictor of aggressive clinical behavior in chondrosarcoma of bone.
  2. albuminuria among aboriginal Australians
    McDonald SP et al. 2002, The p53Pro72Arg polymorphism is associated with albuminuria among aboriginal Australians., Journal of the American Society of Nephrology. 2002 Mar;13(3):677-83. [PubMed 11856771]
  3. alpha-particle carcinogenesis
    Wada I et al. 1999, High rate of small TP53 mutations and infrequent loss of heterozygosity in malignant liver tumors associated with thorotrast: implications for alpha-particle carcinogenesis., Radiation research. 1999 Dec;152(6 Suppl):S125-7. [PubMed 10564952]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: TP53
Diseases sorted by gene-association score: li-fraumeni syndrome* (1762), osteosarcoma, somatic* (1275), choroid plexus papilloma* (1255), adrenal cortical carcinoma* (957), pancreatic cancer* (761), basal cell carcinoma 7* (594), nasopharyngeal carcinoma* (515), hepatocellular carcinoma* (483), choroid plexus cancer* (422), glioma susceptibility 1* (332), breast cancer* (315), small cell cancer of the lung, somatic* (264), megakaryocytic leukemia* (231), chronic lymphocytic leukemia* (216), brca1 hereditary breast and ovarian cancer syndrome* (163), colorectal cancer* (159), brca2 hereditary breast and ovarian cancer syndrome* (141), adenocarcinoma (48), malignant glioma (37), squamous cell carcinoma (35), grade iii astrocytoma (35), papilloma (32), bladder urothelial carcinoma (31), penile cancer (30), cervical cancer, somatic (26), transitional cell carcinoma (25), actinic keratosis (25), serous cystadenocarcinoma (25), bile duct carcinoma (24), barrett's adenocarcinoma (24), basal cell carcinoma (24), brain glioma (24), uterine corpus cancer (23), cervix carcinoma (23), lung cancer (23), skin squamous cell carcinoma (23), intestinal disease (23), bladder transitional cell papilloma (23), conjunctival squamous cell carcinoma (22), xanthogranulomatous cholecystitis (22), papilledema (22), thyroid lymphoma (21), multifocal osteogenic sarcoma (21), glioblastoma multiforme (21), breast ductal carcinoma (21), cell type cancer (20), oral cancer (19), gastroesophageal reflux (19), vulvar intraepithelial neoplasia (18), actinic cheilitis (18), esophageal cancer (18), b cell prolymphocytic leukemia (18), hepadnavirus infection (18), ovary epithelial cancer (17), malignant ovarian surface epithelial-stromal neoplasm (17), atrophy of prostate (17), verrucous carcinoma (17), basaloid squamous cell carcinoma (17), ovarian serous carcinoma (17), endometrial cancer (17), mixed cell type cancer (16), fallopian tube carcinoma (16), cheilitis (16), urinary bladder cancer (16), cll/sll (16), astrocytoma (16), anal squamous cell carcinoma (15), necrotizing sialometaplasia (15), mature teratoma (15), ulcerative stomatitis (15), invasive bladder transitional cell carcinoma (15), hereditary breast ovarian cancer* (15), kidney cancer (14), vulvar sebaceous carcinoma (14), blastoma (14), endometrial adenocarcinoma (14), cystadenocarcinoma (14), bladder cancer, somatic (14), pleomorphic xanthoastrocytoma (14), richter's syndrome (14), larynx cancer (14), in situ carcinoma (14), gallbladder cancer (14), lung occult squamous cell carcinoma (14), clivus meningioma (14), mixed astrocytoma-ependymoma (14), giant cell glioblastoma* (14), parietal lobe neoplasm (14), spinal cord primitive neuroectodermal neoplasm (14), mixed oligodendroglioma-astrocytoma (14), penis carcinoma in situ (14), submandibular gland cancer (14), parameningeal embryonal rhabdomyosarcoma (14), central nervous system lymphoma (13), oral squamous cell carcinoma (13), clear cell cystadenofibroma (13), plantar wart (13), keratocystic odontogenic tumor (13), pleuropulmonary blastoma (13), pulmonary blastoma (13), balkan nephropathy (13), lung benign neoplasm (13), essential thrombocythemia* (13), esophageal basaloid squamous cell carcinoma (13), vulva cancer (13), pancreatic ductal adenocarcinoma (13), scrotal carcinoma (13), adult hepatocellular carcinoma* (12), gliomatosis cerebri (12), familial adenomatous polyposis (12), inverted papilloma (12), gastric lymphoma (12), lip cancer (12), ataxia-telangiectasia (12), stomach cancer (12), breast carcinoma in situ (12), ovarian cancer, somatic (12), tongue squamous cell carcinoma (12), gastrointestinal system benign neoplasm (12), uterine carcinosarcoma (11), mixed glioma (11), ductal carcinoma in situ (11), gastrointestinal system cancer (11), colorectal adenocarcinoma (11), uterine corpus serous adenocarcinoma (11), acinar cell carcinoma (11), maxillary sinus squamous cell carcinoma (11), microglandular adenosis (11), vulva squamous cell carcinoma (11), barrett esophagus/esophageal adenocarcinoma (11), female reproductive endometrioid cancer (11), cerebellum cancer (11), pleomorphic carcinoma (11), gliosarcoma* (11), breast adenocarcinoma (11), cerebellar astrocytoma (11), cell type benign neoplasm (11), chordoid glioma (11), nevus of ota (10), glioma (10), bone giant cell sarcoma (10), brain cancer (10), gliofibroma (10), squamous cell carcinoma, head and neck (10), cystic teratoma (10), ring chromosome 7 (10), fibrillary astrocytoma (10), cholecystitis (10), glioblastoma (10), endocervical adenocarcinoma (10), colorectal adenoma (10), glomangiosarcoma (10), cellular neurofibroma (10), endometrium carcinoma in situ (10), myasthenic syndrome, congenital, 17 (10), soft tissue sarcoma (10), myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects (9), keratoacanthoma (9), frontal convexity meningioma (9), cerebellar angioblastoma (9), kaposi sarcoma (9), larynx verrucous carcinoma (9), epidermal appendage tumor (9), splenic diffuse red pulp small b-cell lymphoma (9), mucoepidermoid esophageal carcinoma (9), esophagus adenocarcinoma (9), lichen sclerosus (9), sarcoma (9), rhabdomyosarcoma (9), esophagitis (9), granulosa cell tumor of the ovary (9), intrahepatic cholangiocarcinoma (9), spitz nevus (9), integumentary system cancer (9), bladder papillary transitional cell neoplasm (9), urinary tract papillary transitional cell benign neoplasm (9), skin melanoma (9), breast malignant phyllodes tumor (9), primary peritoneal carcinoma (9), small cell neuroendocrine carcinoma (9), ovarian clear cell carcinoma (9), hidradenocarcinoma (9), spiradenoma (9), cervical adenocarcinoma (9), sporadic breast cancer (9), b-cell lymphomas (9), non-invasive bladder papillary urothelial neoplasm (9), pre-malignant neoplasm (9), pleomorphic rhabdomyosarcoma (9), embryonal sarcoma (9), pleomorphic adenoma carcinoma (9), female breast cancer (9), pancreatic ductal carcinoma (8), ganglioglioma (8), tongue cancer (8), oral leukoplakia (8), brooke-spiegler syndrome (8), bile duct adenocarcinoma (8), pigmented villonodular synovitis (8), meninges sarcoma (8), xeroderma pigmentosum, variant type (8), calcifying epithelial odontogenic tumor (8), malignant spiradenoma (8), biliary tract neoplasm (8), lung cancer susceptibility 3 (8), bartholin's duct cyst (8), intracranial chondrosarcoma (8), marek disease (8), penis squamous cell carcinoma (8), ovary adenocarcinoma (8), brain ependymoma (8), tetraploidy (8), short-rib thoracic dysplasia 4 with or without polydactyly (8), female reproductive organ cancer (8), retinal cancer (8), sensory system cancer (8), mantle cell lymphoma (8), vestibular gland benign neoplasm (8), endometrial clear cell adenocarcinoma (8), bartholin's gland adenoma (8), adult t-cell leukemia (8), brain stem astrocytic neoplasm (8), peutz-jeghers syndrome (8), medulloblastoma (7), glomus tumor (7), uterine body mixed cancer (7), histiocytoma (7), nijmegen breakage syndrome (7), xeroderma pigmentosum, group a (7), oligodendroglioma (7), dedifferentiated liposarcoma (7), nervous system cancer (7), liposarcoma (7), retinoblastoma (7), mutyh-associated polyposis (7), adenosquamous carcinoma (7), hyperplastic polyposis syndrome (7), supratentorial cancer (7), infratentorial cancer (7), pseudomyxoma peritonei (7), protoplasmic astrocytoma (7), small cell carcinoma (7), reproductive organ cancer (7), bladder carcinoma in situ (7), lung squamous cell carcinoma (7), brain stem cancer (7), estrogen-receptor positive breast cancer (7), rift valley fever (7), myxoid liposarcoma (7), pharynx cancer (7), clear cell adenocarcinoma (7), mucinous adenocarcinoma (7), papillary glioneuronal tumor (7), sweat gland cancer (7), sapho syndrome (7), merkel cell carcinoma (7), connective tissue cancer (7), eccrine sweat gland neoplasm (7), cervical squamous cell carcinoma (7), mutagen sensitivity (7), cerebrum cancer (7), gastrointestinal carcinoma (7), autonomic nervous system neoplasm (7), spinal cord astrocytoma (7), gastric cardia adenocarcinoma (6), diffuse large b-cell lymphoma (6), oropharynx cancer (6), lung papillary adenocarcinoma (6), papillary serous adenocarcinoma (6), adamantinoma of long bones (6), malignant giant cell tumor (6), lymph node cancer (6), brain stem glioma (6), rectal neoplasm (6), cerebral neuroblastoma (6), achalasia (6), lynch syndrome (6), brain glioblastoma multiforme (6), cervix uteri carcinoma in situ (6), thymus cancer (6), angiosarcoma (6), malignant ependymoma (6), uterine corpus endometrial carcinoma (6), peripheral nervous system neoplasm (6), bizarre leiomyoma (6), keratosis (6), lichen planus (6), cerebral convexity meningioma (6), pleomorphic adenoma (6), keratinizing squamous cell carcinoma (6), prostate adenocarcinoma (6), intestinal benign neoplasm (6), leiomyosarcoma (6), malignant fibroxanthoma (6), teratoma (6), cerebral ventricle cancer (6), dermatofibrosarcoma protuberans (6), atrophic gastritis (6), leukemia, acute lymphoblastic 3* (6), thyroid cancer (6), melanoma (6), breast disease (6), ependymoblastoma (6), central nervous system primitive neuroectodermal neoplasm (6), biliary papillomatosis (6), acute lymphocytic leukemia (6), esophageal disease (6), breast benign neoplasm (6), thoracic benign neoplasm (6), spinal cancer (6), prolactin producing pituitary tumor (6), testicular germ cell tumor (6), ureteral obstruction (6), adenoma (6), cervical carcinosarcoma (5), hypoxia (5), lip disease (5), prostate cancer (5), sarcomatoid squamous cell skin carcinoma (5), ocular cancer (5), fallopian tube adenocarcinoma (5), bartholin's gland benign neoplasm (5), squamous cell papilloma (5), inflammatory myofibroblastic tumor (5), malignant peripheral nerve sheath tumor (5), nervous system benign neoplasm (5), male reproductive organ cancer (5), endometrial stromal sarcoma (5), clear cell renal cell carcinoma (5), organ system benign neoplasm (5), central nervous system organ benign neoplasm (5), muscle cancer (5), myxosarcoma (5), endocervical carcinoma (5), olfactory groove meningioma (5), atypical follicular adenoma (5), childhood leukemia (5), nasal cavity adenocarcinoma (5), pancreas adenocarcinoma (5), synchronous bilateral breast carcinoma (5), cataract 24, anterior polar (5), sclerosing liposarcoma (5), glycogen-rich clear cell breast carcinoma (5), hydrocephalus (5), anogenital venereal wart (5), juvenile pilocytic astrocytoma (5), familial colorectal cancer (5), tonsil cancer (5), non-proliferative fibrocystic change of the breast (5), epidural neoplasm (5), gastric cancer, somatic (5), multiple cranial nerve palsy (4), anterior cranial fossa meningioma (4), ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (4), meningeal melanomatosis (4), liver angiosarcoma (4), bone squamous cell carcinoma (4), duodenum cancer (4), signet ring cell adenocarcinoma (4), clear cell ependymoma (4), cervix small cell carcinoma (4), breast metaplastic carcinoma (4), mature b-cell neoplasm (4), cerebral primitive neuroectodermal tumor (4), agraphia (4), lichen disease (4), periosteal osteogenic sarcoma (4), adult medulloblastoma (4), small cell sarcoma (4), cellular schwannoma (4), chronic salpingitis (4), bladder squamous cell carcinoma (4), cribriform carcinoma (4), conjunctival degeneration (4), localized osteosarcoma (4), chromophobe adenoma (4), medullomyoblastoma (4), malignant mesenchymoma (4), cerebellar liponeurocytoma (3), optic nerve neoplasm (3), split-hand/foot malformation 4 (3), huntington disease (3), pinguecula (3), optic nerve glioma (3), vaccinia (3), malignant melanoma, somatic (3), differentiated thyroid carcinoma (3), mucoepidermoid carcinoma (3), cystitis (3), chordoma (3), gastrointestinal stromal tumor (2), acquired immunodeficiency syndrome (2), multiple myeloma (2), aplastic anemia (2), uveal melanoma (2), ewing sarcoma (2), endocrine gland cancer (2), neuroblastoma (2), autosomal genetic disease (2), germ cell and embryonal cancer (1), meningioma, familial (1), leukemia, acute myeloid (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.06 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 470.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.00202-0.426 Picture PostScript Text
3' UTR -518.071496-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00870 - P53 DNA-binding domain

SCOP Domains:
49417 - p53-like transcription factors

ModBase Predicted Comparative 3D Structure on P04637-5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  EF101869 - Homo sapiens cell-line HDLM2 nonfunctional tumor suppressor p53 (TP53) mRNA, complete cds.
AM076971 - Homo sapiens partial mRNA for tumor protein p53 mutant form (TP53 gene), classical Hodgkin Lymphoma cell line HDLM-2.
EF101868 - Homo sapiens cell-line L1236 nonfunctional tumor suppressor p53 (TP53) mRNA, complete cds.
AM076972 - Homo sapiens partial mRNA for tumor protein p53 mutant form (TP53 gene), classical Hodgkin Lymphoma cell line L1236.
DQ186650 - Homo sapiens del133 p53 isoform (TP53) mRNA, complete cds.
DQ186651 - Homo sapiens del133 p53 beta isoform (TP53) mRNA, complete cds.
DQ186652 - Homo sapiens del133 p53 gamma isoform (TP53) mRNA, complete cds.
HW061196 - JP 2012529430-A/71: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061197 - JP 2012529430-A/72: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061198 - JP 2012529430-A/73: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482151 - Sequence 134 from Patent WO2011072091.
JA482152 - Sequence 135 from Patent WO2011072091.
JA482153 - Sequence 136 from Patent WO2011072091.
JB252004 - Sequence 71 from Patent EP2440214.
JB252005 - Sequence 72 from Patent EP2440214.
JB252006 - Sequence 73 from Patent EP2440214.
JE980443 - Sequence 134 from Patent EP2862929.
JE980444 - Sequence 135 from Patent EP2862929.
JE980445 - Sequence 136 from Patent EP2862929.
LP764903 - Sequence 71 from Patent EP3276004.
LP764904 - Sequence 72 from Patent EP3276004.
LP764905 - Sequence 73 from Patent EP3276004.
JN900492 - Homo sapiens tumor suppressor TP53 (TP53) mRNA, complete cds, alternatively spliced.
HW061192 - JP 2012529430-A/67: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061193 - JP 2012529430-A/68: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061194 - JP 2012529430-A/69: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061195 - JP 2012529430-A/70: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482147 - Sequence 130 from Patent WO2011072091.
JA482148 - Sequence 131 from Patent WO2011072091.
JA482149 - Sequence 132 from Patent WO2011072091.
JA482150 - Sequence 133 from Patent WO2011072091.
JB252000 - Sequence 67 from Patent EP2440214.
JB252001 - Sequence 68 from Patent EP2440214.
JB252002 - Sequence 69 from Patent EP2440214.
JB252003 - Sequence 70 from Patent EP2440214.
JE980439 - Sequence 130 from Patent EP2862929.
JE980440 - Sequence 131 from Patent EP2862929.
JE980441 - Sequence 132 from Patent EP2862929.
JE980442 - Sequence 133 from Patent EP2862929.
LP764899 - Sequence 67 from Patent EP3276004.
LP764900 - Sequence 68 from Patent EP3276004.
LP764901 - Sequence 69 from Patent EP3276004.
LP764902 - Sequence 70 from Patent EP3276004.
LY486121 - KR 1020170007492-A/1: METHODS AND COMPOSITIONS FOR PREVENTING ISCHEMIA REPERFUSION INJURY IN ORGANS.
LZ228280 - JP 2017521374-A/1: METHODS AND COMPOSITIONS FOR PREVENTING ISCHEMIA REPERFUSION INJURY IN ORGANS.
DM163612 - Method for promotion of p53 expression.
HV708907 - JP 2012506450-A/5: Methods for treating eye disorders.
DQ186648 - Homo sapiens p53 beta isoform (TP53) mRNA, complete cds.
DQ186649 - Homo sapiens p53 gamma isoform (TP53) mRNA, complete cds.
DQ286964 - Homo sapiens p53 protein (TP53) mRNA, complete cds, alternatively spliced.
DQ191317 - Homo sapiens p53 protein (TP53) mRNA, complete cds, alternatively spliced.
AF052180 - Homo sapiens clone 24564 mRNA sequence.
AK223026 - Homo sapiens mRNA for tumor protein p53 variant, clone: JTH07296.
X01405 - Human mRNA fragment for phosphoprotein p53.
AB082923 - Homo sapiens mRNA for P53, complete cds.
BC003596 - Homo sapiens tumor protein p53, mRNA (cDNA clone MGC:646 IMAGE:3544714), complete cds.
AF307851 - Homo sapiens p53 protein mRNA, complete cds.
JN214348 - Homo sapiens cell-line HCT116p53-/- nonfunctional delta40-P53 transcript variant (TP53) mRNA, complete sequence.
FJ207420 - Homo sapiens mutant p53 mRNA, complete cds.
JD123340 - Sequence 104364 from Patent EP1572962.
JD299783 - Sequence 280807 from Patent EP1572962.
JD378958 - Sequence 359982 from Patent EP1572962.
JD533970 - Sequence 514994 from Patent EP1572962.
JD321581 - Sequence 302605 from Patent EP1572962.
JD064504 - Sequence 45528 from Patent EP1572962.
JD295458 - Sequence 276482 from Patent EP1572962.
JD333220 - Sequence 314244 from Patent EP1572962.
JD071890 - Sequence 52914 from Patent EP1572962.
JD398255 - Sequence 379279 from Patent EP1572962.
JD286216 - Sequence 267240 from Patent EP1572962.
JD480909 - Sequence 461933 from Patent EP1572962.
JD543982 - Sequence 525006 from Patent EP1572962.
JD542311 - Sequence 523335 from Patent EP1572962.
JD293418 - Sequence 274442 from Patent EP1572962.
JD562184 - Sequence 543208 from Patent EP1572962.
JD432939 - Sequence 413963 from Patent EP1572962.
JD457509 - Sequence 438533 from Patent EP1572962.
JD202361 - Sequence 183385 from Patent EP1572962.
JD141194 - Sequence 122218 from Patent EP1572962.
JD266224 - Sequence 247248 from Patent EP1572962.
JD564555 - Sequence 545579 from Patent EP1572962.
JD566766 - Sequence 547790 from Patent EP1572962.
JD266223 - Sequence 247247 from Patent EP1572962.
JD297255 - Sequence 278279 from Patent EP1572962.
JD393077 - Sequence 374101 from Patent EP1572962.
JD486665 - Sequence 467689 from Patent EP1572962.
AK297927 - Homo sapiens cDNA FLJ54299 complete cds, highly similar to Cellular tumor antigen p53.
AK297462 - Homo sapiens cDNA FLJ54297 complete cds, highly similar to Cellular tumor antigen p53.
JD168340 - Sequence 149364 from Patent EP1572962.
JD527824 - Sequence 508848 from Patent EP1572962.
K03199 - Human p53 cellular tumor antigen mRNA, complete cds.
AK225838 - Homo sapiens mRNA for Cellular tumor antigen p53 variant, clone: FCC127A11.
JD298986 - Sequence 280010 from Patent EP1572962.
JD168621 - Sequence 149645 from Patent EP1572962.
JQ694049 - Homo sapiens isolate iPCH358_Col1 tumor suppressor p53 (TP53) mRNA, complete cds.
JQ694050 - Homo sapiens isolate iPCH358_Col3 tumor suppressor p53 (TP53) mRNA, complete cds.
JQ694051 - Homo sapiens isolate iPCH358_Col11 tumor suppressor p53 (TP53) mRNA, complete cds.
JD317542 - Sequence 298566 from Patent EP1572962.
JD059195 - Sequence 40219 from Patent EP1572962.
DQ648886 - Homo sapiens p53+ins9a (TP53) mRNA, 3' UTR, alternatively spliced.
DQ648887 - Homo sapiens p53-Ex10 isoform (TP53) mRNA, partial cds, alternatively spliced.
JQ026208 - Homo sapiens clone c.398-399ins4 mutated tumor suppressor protein P53 mRNA sequence.
JD477257 - Sequence 458281 from Patent EP1572962.
JQ026207 - Homo sapiens clone c.159del1 mutated tumor suppressor protein P53 mRNA sequence.
AM076970 - Homo sapiens partial mRNA for tumor protein p53 mutant form (TP53 gene), classical Hodgkin Lymphoma cell line L428.
DQ263704 - Homo sapiens tumor protein p53 (TP53) mRNA, complete cds.
EF101867 - Homo sapiens cell-line L428 nonfunctional tumor suppressor p53 (TP53) mRNA, complete cds.
JN601513 - Homo sapiens isolate MV4-11 mutant p53 protein mRNA, partial cds.
JN601514 - Homo sapiens isolate Kasumi-1 mutant p53 protein mRNA, partial cds.
JN601515 - Homo sapiens isolate CMS mutant p53 protein mRNA, partial cds.
JN601516 - Homo sapiens isolate THP-1 truncated p53 protein mRNA, partial cds.
JQ026210 - Homo sapiens clone c.792_796del5 mutated tumor suppressor protein P53 mRNA sequence.
MG595979 - Homo sapiens isolate TWH-1414-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595980 - Homo sapiens isolate TWH-0571-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595981 - Homo sapiens isolate TWH-0357-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595982 - Homo sapiens isolate TWH-1016-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595983 - Homo sapiens isolate HKSH-0023-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595984 - Homo sapiens isolate PMH-0020-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595985 - Homo sapiens isolate TWH-0863-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595986 - Homo sapiens isolate TWH-1542-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595987 - Homo sapiens isolate TWH-0104-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595988 - Homo sapiens isolate HKSH-0182-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595989 - Homo sapiens isolate TWH-0855-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595990 - Homo sapiens isolate KWH-0019-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595991 - Homo sapiens isolate TWH-1681-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595992 - Homo sapiens isolate TWH-0602-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
MG595993 - Homo sapiens isolate TWH-0395-0-1 truncated tumor protein p53 (TP53) mRNA, complete cds.
MG595994 - Homo sapiens isolate TWH-1698-0-1 mutant tumor protein p53 (TP53) mRNA, complete cds.
M14695 - Human p53 cellular tumor antigen mRNA, complete cds.
M14694 - Human p53 cellular tumor antigen mRNA, complete cds.
X02469 - Human mRNA for p53 cellular tumor antigen.
AK312568 - Homo sapiens cDNA, FLJ92943, Homo sapiens tumor protein p53 (Li-Fraumeni syndrome) (TP53), mRNA.
KJ897694 - Synthetic construct Homo sapiens clone ccsbBroadEn_07088 TP53 gene, encodes complete protein.
KR709864 - Synthetic construct Homo sapiens clone CCSBHm_00006902 TP53 (TP53) mRNA, encodes complete protein.
KR709865 - Synthetic construct Homo sapiens clone CCSBHm_00006929 TP53 (TP53) mRNA, encodes complete protein.
KR709866 - Synthetic construct Homo sapiens clone CCSBHm_00006983 TP53 (TP53) mRNA, encodes complete protein.
KR709867 - Synthetic construct Homo sapiens clone CCSBHm_00007040 TP53 (TP53) mRNA, encodes complete protein.
BT019622 - Homo sapiens tumor protein p53 (Li-Fraumeni syndrome) mRNA, complete cds.
DQ892492 - Synthetic construct clone IMAGE:100005122; FLH186809.01X; RZPDo839A0972D tumor protein p53 (Li-Fraumeni syndrome) (TP53) gene, encodes complete protein.
DQ895704 - Synthetic construct Homo sapiens clone IMAGE:100010164; FLH186805.01L; RZPDo839A0962D tumor protein p53 (Li-Fraumeni syndrome) (TP53) gene, encodes complete protein.
X60011 - Human mRNA for mutated p53 transformation suppressor gene.
X60012 - Human mRNA for mutated p53 transformation suppressor gene.
X60013 - Human mRNA for mutated p53 transformation suppressor gene.
X60014 - Human mRNA for mutated p53 transformation suppressor gene.
X60015 - Human mRNA for mutated p53 transformation suppressor gene.
X60016 - Human mRNA for mutated p53 transformation suppressor gene.
X60017 - Human mRNA for mutated p53 transformation suppressor gene.
X60018 - Human mRNA for mutated p53 transformation suppressor gene.
X60019 - Human mRNA for mutated p53 transformation suppressor gene.
X60020 - Human mRNA for mutated p53 transformation suppressor gene.
AB527267 - Synthetic construct DNA, clone: pF1KB8730, Homo sapiens TP53 gene for tumor protein p53, without stop codon, in Flexi system.
JQ026209 - Homo sapiens clone c.672_673ins5 mutated tumor suppressor protein P53 mRNA sequence.
LP866503 - Sequence 57 from Patent WO2017162888.
AY429684 - Homo sapiens tumor suppressor p53 (TP53) mRNA, partial cds.
S66666 - p53=tumor suppressor {alternatively spliced, exon 9-10} [human, Molt-4, T-lymphoblastic leukemia cell line, mRNA PartialMutant, 160 nt].
DL476249 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
DL476265 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941369 - JP 2012152216-A/194: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HV941385 - JP 2012152216-A/210: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798275 - JP 2014236738-A/194: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798291 - JP 2014236738-A/210: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476266 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941386 - JP 2012152216-A/211: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798292 - JP 2014236738-A/211: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
KY907121 - Homo sapiens isolate CC2_TP53 p53 (TP53) mRNA, partial cds.
KY907122 - Homo sapiens isolate CC3_TP53 p53 (TP53) mRNA, partial cds.
KY907123 - Homo sapiens isolate CC5_TP53 p53 (TP53) mRNA, partial cds.
KY907124 - Homo sapiens isolate CC7_TP53 p53 (TP53) mRNA, partial cds.
KY907125 - Homo sapiens isolate CC10_TP53 p53 (TP53) mRNA, partial cds.
KY907126 - Homo sapiens isolate CC11_TP53 p53 (TP53) mRNA, partial cds.
KY907127 - Homo sapiens isolate CC12_TP53 p53 (TP53) mRNA, partial cds.
KY907128 - Homo sapiens isolate CC15_TP53 p53 (TP53) mRNA, partial cds.
KY907129 - Homo sapiens isolate CC17_TP53 p53 (TP53) mRNA, partial cds.
KY907130 - Homo sapiens isolate CC19_TP53 p53 (TP53) mRNA, partial cds.
KY907131 - Homo sapiens isolate CC20_TP53 p53 (TP53) mRNA, partial cds.
KY907132 - Homo sapiens isolate CC21_TP53 p53 (TP53) mRNA, partial cds.
KY907133 - Homo sapiens isolate CC22_TP53 p53 (TP53) mRNA, partial cds.
KY907134 - Homo sapiens isolate CC23_TP53 p53 (TP53) mRNA, partial cds.
KY907135 - Homo sapiens isolate CC24_TP53 p53 (TP53) mRNA, partial cds.
KY907136 - Homo sapiens isolate CC26_TP53 p53 (TP53) mRNA, partial cds.
KY907137 - Homo sapiens isolate CC27_TP53 p53 (TP53) mRNA, partial cds.
KY907138 - Homo sapiens isolate CC28_TP53 p53 (TP53) mRNA, partial cds.
KY907139 - Homo sapiens isolate CC29_TP53 p53 (TP53) mRNA, partial cds.
KY907140 - Homo sapiens isolate CC30_TP53 p53 (TP53) mRNA, partial cds.
KY907141 - Homo sapiens isolate CC33_TP53 p53 (TP53) mRNA, partial cds.
KY907142 - Homo sapiens isolate CC34_TP53 p53 (TP53) mRNA, partial cds.
KY907143 - Homo sapiens isolate CC35_TP53 p53 (TP53) mRNA, partial cds.
KY907144 - Homo sapiens isolate CC36_TP53 p53 (TP53) mRNA, partial cds.
KY907145 - Homo sapiens isolate CC37_TP53 p53 (TP53) mRNA, partial cds.
KY907146 - Homo sapiens isolate CC38_TP53 p53 (TP53) mRNA, partial cds.
DL476283 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941403 - JP 2012152216-A/228: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798309 - JP 2014236738-A/228: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476292 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941412 - JP 2012152216-A/237: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798318 - JP 2014236738-A/237: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476274 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941394 - JP 2012152216-A/219: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798300 - JP 2014236738-A/219: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476250 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941370 - JP 2012152216-A/195: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798276 - JP 2014236738-A/195: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476245 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941365 - JP 2012152216-A/190: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798271 - JP 2014236738-A/190: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
KC820708 - Homo sapiens isolate 1 tumor protein 53 (TP53) mRNA, partial cds.
KC820709 - Homo sapiens isolate 2 tumor protein 53 (TP53) mRNA, partial cds.
KC820710 - Homo sapiens isolate 3 tumor protein 53 (TP53) mRNA, partial cds.
KC820711 - Homo sapiens isolate 4 tumor protein 53 (TP53) mRNA, partial cds.
KC820712 - Homo sapiens isolate 5 tumor protein 53 (TP53) mRNA, partial cds.
KC820713 - Homo sapiens isolate 6 tumor protein 53 (TP53) mRNA, partial cds.
KC820714 - Homo sapiens isolate 7 tumor protein 53 (TP53) mRNA, partial cds.
KC820715 - Homo sapiens isolate 8 tumor protein 53 (TP53) mRNA, partial cds.
KC820716 - Homo sapiens isolate 9 tumor protein 53 (TP53) mRNA, partial cds.
KC820717 - Homo sapiens isolate 10 tumor protein 53 (TP53) mRNA, partial cds.
KC820718 - Homo sapiens isolate 11 tumor protein 53 (TP53) mRNA, partial cds.
KC820719 - Homo sapiens isolate 12 tumor protein 53 (TP53) mRNA, partial cds.
KC820720 - Homo sapiens isolate 13 tumor protein 53 (TP53) mRNA, partial cds.
KC820721 - Homo sapiens isolate 14 tumor protein 53 (TP53) mRNA, partial cds.
KC820722 - Homo sapiens isolate 15 tumor protein 53 (TP53) mRNA, partial cds.
KC820723 - Homo sapiens isolate 16 tumor protein 53 (TP53) mRNA, partial cds.
KC820724 - Homo sapiens isolate 17 tumor protein 53 (TP53) mRNA, partial cds.
KC820725 - Homo sapiens isolate 18 tumor protein 53 (TP53) mRNA, partial cds.
KC820726 - Homo sapiens isolate 19 tumor protein 53 (TP53) mRNA, partial cds.
KC820727 - Homo sapiens isolate 20 tumor protein 53 (TP53) mRNA, partial cds.
KC820728 - Homo sapiens isolate 21 tumor protein 53 (TP53) mRNA, partial cds.
KC820729 - Homo sapiens isolate 22 tumor protein 53 (TP53) mRNA, partial cds.
KC820730 - Homo sapiens isolate 23 tumor protein 53 (TP53) mRNA, partial cds.
KC820731 - Homo sapiens isolate 24 tumor protein 53 (TP53) mRNA, partial cds.
KC820732 - Homo sapiens isolate 25 tumor protein 53 (TP53) mRNA, partial cds.
KC820733 - Homo sapiens isolate 26 tumor protein 53 (TP53) mRNA, partial cds.
KC820734 - Homo sapiens isolate 27 tumor protein 53 (TP53) mRNA, partial cds.
KC820735 - Homo sapiens isolate 28 tumor protein 53 (TP53) mRNA, partial cds.
KC820736 - Homo sapiens isolate 29 tumor protein 53 (TP53) mRNA, partial cds.
KC820737 - Homo sapiens isolate 30 tumor protein 53 (TP53) mRNA, partial cds.
KC820738 - Homo sapiens isolate 31 tumor protein 53 (TP53) mRNA, partial cds.
KC820739 - Homo sapiens isolate 32 tumor protein 53 (TP53) mRNA, partial cds.
KC820740 - Homo sapiens isolate 33 tumor protein 53 (TP53) mRNA, partial cds.
KC820741 - Homo sapiens isolate 34 tumor protein 53 (TP53) mRNA, partial cds.
KC820742 - Homo sapiens isolate 35 tumor protein 53 (TP53) mRNA, partial cds.
KC820743 - Homo sapiens isolate 36 tumor protein 53 (TP53) mRNA, partial cds.
KC820744 - Homo sapiens isolate 37 tumor protein 53 (TP53) mRNA, partial cds.
KC820745 - Homo sapiens isolate 38 tumor protein 53 (TP53) mRNA, partial cds.
KC820746 - Homo sapiens isolate 39 tumor protein 53 (TP53) mRNA, partial cds.
KC820747 - Homo sapiens isolate 40 tumor protein 53 (TP53) mRNA, partial cds.
KC820748 - Homo sapiens isolate 41 tumor protein 53 (TP53) mRNA, partial cds.
KC820749 - Homo sapiens isolate 42 tumor protein 53 (TP53) mRNA, partial cds.
KC820750 - Homo sapiens isolate 43 tumor protein 53 (TP53) mRNA, partial cds.
KC820751 - Homo sapiens isolate 44 tumor protein 53 (TP53) mRNA, partial cds.
KC820752 - Homo sapiens isolate 45 tumor protein 53 (TP53) mRNA, partial cds.
KC820753 - Homo sapiens isolate 46 tumor protein 53 (TP53) mRNA, partial cds.
KC820754 - Homo sapiens isolate 47 tumor protein 53 (TP53) mRNA, partial cds.
KC820755 - Homo sapiens isolate 48 tumor protein 53 (TP53) mRNA, partial cds.
KC820756 - Homo sapiens isolate 49 tumor protein 53 (TP53) mRNA, partial cds.
KC820757 - Homo sapiens isolate 50 tumor protein 53 (TP53) mRNA, partial cds.
KC820758 - Homo sapiens isolate 51 tumor protein 53 (TP53) mRNA, partial cds.
KC820759 - Homo sapiens isolate 52 mutant tumor protein 53 (TP53) mRNA, partial cds.
KC820760 - Homo sapiens isolate 53 tumor protein 53 (TP53) mRNA, partial cds.
KC820761 - Homo sapiens isolate 54 tumor protein 53 (TP53) mRNA, partial cds.
KC820762 - Homo sapiens isolate 55 tumor protein 53 (TP53) mRNA, partial cds.
KC820763 - Homo sapiens isolate 56 tumor protein 53 (TP53) mRNA, partial cds.
KC820764 - Homo sapiens isolate 57 tumor protein 53 (TP53) mRNA, partial cds.
KC820765 - Homo sapiens isolate 58 tumor protein 53 (TP53) mRNA, partial cds.
KC820766 - Homo sapiens isolate 59 tumor protein 53 (TP53) mRNA, partial cds.
KC820767 - Homo sapiens isolate 60 tumor protein 53 (TP53) mRNA, partial cds.
KC820768 - Homo sapiens isolate 61 tumor protein 53 (TP53) mRNA, partial cds.
KC820769 - Homo sapiens isolate 62 tumor protein 53 (TP53) mRNA, partial cds.
KC820770 - Homo sapiens isolate 63 tumor protein 53 (TP53) mRNA, partial cds.
KC820771 - Homo sapiens isolate 64 tumor protein 53 (TP53) mRNA, partial cds.
KC820772 - Homo sapiens isolate 65 tumor protein 53 (TP53) mRNA, partial cds.
KC820773 - Homo sapiens isolate 66 tumor protein 53 (TP53) mRNA, partial cds.
KC820774 - Homo sapiens isolate 67 tumor protein 53 (TP53) mRNA, partial cds.
KC820775 - Homo sapiens isolate 68 tumor protein 53 (TP53) mRNA, partial cds.
KC820776 - Homo sapiens isolate 69 tumor protein 53 (TP53) mRNA, partial cds.
KC820777 - Homo sapiens isolate 70 tumor protein 53 (TP53) mRNA, partial cds.
KC820778 - Homo sapiens isolate 71 tumor protein 53 (TP53) mRNA, partial cds.
KC820779 - Homo sapiens isolate 72 tumor protein 53 (TP53) mRNA, partial cds.
KC820780 - Homo sapiens isolate 73 tumor protein 53 (TP53) mRNA, partial cds.
KC820781 - Homo sapiens isolate 74 tumor protein 53 (TP53) mRNA, partial cds.
KC820782 - Homo sapiens isolate 75 tumor protein 53 (TP53) mRNA, partial cds.
KC820783 - Homo sapiens isolate 76 tumor protein 53 (TP53) mRNA, partial cds.
KC820784 - Homo sapiens isolate 77 tumor protein 53 (TP53) mRNA, partial cds.
KC820785 - Homo sapiens isolate 78 tumor protein 53 (TP53) mRNA, partial cds.
KC820786 - Homo sapiens isolate 79 tumor protein 53 (TP53) mRNA, partial cds.
DL476251 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941371 - JP 2012152216-A/196: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798277 - JP 2014236738-A/196: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476297 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
DL476305 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941417 - JP 2012152216-A/242: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HV941425 - JP 2012152216-A/250: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798323 - JP 2014236738-A/242: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798331 - JP 2014236738-A/250: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476301 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941421 - JP 2012152216-A/246: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798327 - JP 2014236738-A/246: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476299 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941419 - JP 2012152216-A/244: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798325 - JP 2014236738-A/244: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476306 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941426 - JP 2012152216-A/251: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798332 - JP 2014236738-A/251: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476302 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941422 - JP 2012152216-A/247: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798328 - JP 2014236738-A/247: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476300 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941420 - JP 2012152216-A/245: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798326 - JP 2014236738-A/245: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476303 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941423 - JP 2012152216-A/248: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798329 - JP 2014236738-A/248: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DQ648884 - Homo sapiens p53-Ex4 isoform (TP53) mRNA, partial cds, alternatively spliced.
DQ648885 - Homo sapiens p53-Ex(2-4) isoform (TP53) mRNA, partial cds, alternatively spliced.
X60010 - Human mRNA for mutated p53 transformation suppressor gene.
DL476293 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941413 - JP 2012152216-A/238: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798319 - JP 2014236738-A/238: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476284 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941404 - JP 2012152216-A/229: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798310 - JP 2014236738-A/229: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476285 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941405 - JP 2012152216-A/230: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798311 - JP 2014236738-A/230: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476267 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941387 - JP 2012152216-A/212: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798293 - JP 2014236738-A/212: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476291 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941411 - JP 2012152216-A/236: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798317 - JP 2014236738-A/236: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476276 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941396 - JP 2012152216-A/221: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798302 - JP 2014236738-A/221: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476277 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941397 - JP 2012152216-A/222: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798303 - JP 2014236738-A/222: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476268 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941388 - JP 2012152216-A/213: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798294 - JP 2014236738-A/213: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476286 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941406 - JP 2012152216-A/231: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798312 - JP 2014236738-A/231: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476287 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941407 - JP 2012152216-A/232: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798313 - JP 2014236738-A/232: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476278 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941398 - JP 2012152216-A/223: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798304 - JP 2014236738-A/223: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476279 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941399 - JP 2012152216-A/224: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798305 - JP 2014236738-A/224: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476269 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941389 - JP 2012152216-A/214: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798295 - JP 2014236738-A/214: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476280 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941400 - JP 2012152216-A/225: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798306 - JP 2014236738-A/225: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476288 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941408 - JP 2012152216-A/233: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798314 - JP 2014236738-A/233: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476281 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941401 - JP 2012152216-A/226: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798307 - JP 2014236738-A/226: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476263 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941383 - JP 2012152216-A/208: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798289 - JP 2014236738-A/208: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476282 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941402 - JP 2012152216-A/227: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798308 - JP 2014236738-A/227: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476270 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941390 - JP 2012152216-A/215: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798296 - JP 2014236738-A/215: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476264 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941384 - JP 2012152216-A/209: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798290 - JP 2014236738-A/209: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DQ485152 - Homo sapiens cell-line Hec50co truncated p53 splice variant (TP53) mRNA, partial cds, aberrantly spliced.
DL476289 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941409 - JP 2012152216-A/234: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798315 - JP 2014236738-A/234: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476273 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941393 - JP 2012152216-A/218: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798299 - JP 2014236738-A/218: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476246 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941366 - JP 2012152216-A/191: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798272 - JP 2014236738-A/191: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
AK303277 - Homo sapiens cDNA FLJ50936 complete cds, highly similar to Cellular tumor antigen p53.
CU678522 - Synthetic construct Homo sapiens gateway clone IMAGE:100019213 5' read TP53 mRNA.
DL476256 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941376 - JP 2012152216-A/201: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798282 - JP 2014236738-A/201: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476257 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941377 - JP 2012152216-A/202: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798283 - JP 2014236738-A/202: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476275 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941395 - JP 2012152216-A/220: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798301 - JP 2014236738-A/220: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476294 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941414 - JP 2012152216-A/239: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798320 - JP 2014236738-A/239: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476295 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941415 - JP 2012152216-A/240: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798321 - JP 2014236738-A/240: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DQ401704 - Homo sapiens p53deltaEx4 mRNA, partial cds.
DL476259 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941379 - JP 2012152216-A/204: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798285 - JP 2014236738-A/204: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476260 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941380 - JP 2012152216-A/205: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798286 - JP 2014236738-A/205: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DQ648883 - Homo sapiens p53+ins1a isoform (TP53) mRNA, complete sequence, alternatively spliced.
DL476261 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941381 - JP 2012152216-A/206: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798287 - JP 2014236738-A/206: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
DL476247 - Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Medical Conditions.
HV941367 - JP 2012152216-A/192: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
HW798273 - JP 2014236738-A/192: Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases.
AY627884 - Homo sapiens p53 tumor suppressor mRNA, 5' UTR and partial cds.
JD116459 - Sequence 97483 from Patent EP1572962.
JD516513 - Sequence 497537 from Patent EP1572962.
JD465582 - Sequence 446606 from Patent EP1572962.
JD396487 - Sequence 377511 from Patent EP1572962.
JD300651 - Sequence 281675 from Patent EP1572962.
JD412359 - Sequence 393383 from Patent EP1572962.
LQ948588 - Sequence 5 from Patent WO2014043292.
LQ948589 - Sequence 6 from Patent WO2014043292.
LQ948590 - Sequence 7 from Patent WO2014043292.
LQ948584 - Sequence 1 from Patent WO2014043292.
LQ948585 - Sequence 2 from Patent WO2014043292.
LQ948586 - Sequence 3 from Patent WO2014043292.
LQ948587 - Sequence 4 from Patent WO2014043292.
MP140196 - Sequence 5 from Patent EP3444349.
MP140197 - Sequence 6 from Patent EP3444349.
MP140198 - Sequence 7 from Patent EP3444349.
MP140192 - Sequence 1 from Patent EP3444349.
MP140193 - Sequence 2 from Patent EP3444349.
MP140194 - Sequence 3 from Patent EP3444349.
MP140195 - Sequence 4 from Patent EP3444349.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04110 - Cell cycle
hsa04115 - p53 signaling pathway
hsa04210 - Apoptosis
hsa04310 - Wnt signaling pathway
hsa04722 - Neurotrophin signaling pathway
hsa05014 - Amyotrophic lateral sclerosis (ALS)
hsa05016 - Huntington's disease
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05212 - Pancreatic cancer
hsa05213 - Endometrial cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05216 - Thyroid cancer
hsa05217 - Basal cell carcinoma
hsa05218 - Melanoma
hsa05219 - Bladder cancer
hsa05220 - Chronic myeloid leukemia
hsa05222 - Small cell lung cancer
hsa05223 - Non-small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_atmPathway - ATM Signaling Pathway
h_telPathway - Telomeres, Telomerase, Cellular Aging, and Immortality
h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system
h_pmlPathway - Regulation of transcriptional activity by PML
h_btg2Pathway - BTG family proteins and cell cycle regulation
h_rbPathway - RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
h_rnaPathway - Double Stranded RNA Induced Gene Expression
h_tertpathway - Overview of telomerase protein component gene hTert Transcriptional Regulation
h_tidPathway - Chaperones modulate interferon Signaling Pathway
h_chemicalPathway - Apoptotic Signaling in Response to DNA Damage
h_plk3Pathway - Regulation of cell cycle progression by Plk3
h_ctcfPathway - CTCF: First Multivalent Nuclear Factor
h_EfpPathway - Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
h_atrbrcaPathway - Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility
h_g1Pathway - Cell Cycle: G1/S Check Point
h_arfPathway - Tumor Suppressor Arf Inhibits Ribosomal Biogenesis
h_g2Pathway - Cell Cycle: G2/M Checkpoint
h_p53Pathway - p53 Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P04637 (Reactome details) participates in the following event(s):

R-HSA-2997706 MDM2 SUMOylates TP53 with SUMO2,3
R-HSA-6804762 TP53 forms homotetramers
R-HSA-992696 p53, SIN3A and MYB form a complex
R-NUL-992753 p53 and Sin3a bind c-Myb
R-HSA-3221982 BANP binds TP53
R-HSA-3239014 MAPKAPK5 phosphorylates TP53
R-HSA-4395236 TP53 binds promoters of MIR34 genes
R-HSA-5628899 TP53 binds the TIGAR gene
R-HSA-5629187 TP53 binds regulatory elements of SESN1,2,3 genes
R-HSA-5632759 TP53 binds the SCO2 gene
R-HSA-5632887 TP53 binds the RRM2B gene
R-HSA-5632914 TP53 binds the GLS2 promoter
R-HSA-5632939 TP53 binds the PTEN promoter
R-HSA-5633460 MDM2 binds TP53
R-HSA-5693609 ATM phosphorylates TP53 at S15
R-HSA-6791409 TP53 binds the CCNG1 gene
R-HSA-6799332 ATR phosphorylates TP53
R-HSA-6799431 TP53 binds HIPK1
R-HSA-6805035 TP53 binds STK11 and NUAK1
R-HSA-6805103 AURKA phosphorylates TP53
R-HSA-6805109 CDK2 phosphorylates TP53
R-HSA-6805276 CDK5 phosphorylates TP53
R-HSA-6805399 TAF1 phosphorylates TP53
R-HSA-6805470 AMPK phosphorylates TP53
R-HSA-6805479 TP53RK phosphorylates TP53
R-HSA-6805755 EHMT1:EHMT2 dimethylates TP53
R-HSA-8952128 RUNX3 binds TP53
R-HSA-3215310 USP7 deubiquitinates TP53 and counteracts MDM2
R-HSA-6804996 p14-ARF sequesters MDM2
R-HSA-5689973 USP10,USP24,USP42 deubiquitinate TP53
R-HSA-69685 CHEK2 phosphorylates TP53
R-HSA-3786258 TP53 binds the CDKN1A promoter
R-HSA-6799246 CHEK1 phosphorylates TP53
R-HSA-6805285 PLK3 phosphorylates TP53
R-HSA-264435 Dissociation of the COP1-p53 complex
R-HSA-3215152 TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter
R-HSA-3215251 TP53INP1 and HIPK2 bind TP53
R-HSA-3222093 BRD7 binds TP53 and EP300
R-HSA-3222128 NOC2L binds TP53
R-HSA-3222237 SMYD2 methylates TP53
R-HSA-3700997 TP53 binds the MDM2 gene
R-HSA-4331331 TP53 binds the PMAIP1 (NOXA) promoter
R-HSA-5633295 TP53 binds the NDRG1 gene promoter
R-HSA-5633414 TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes
R-HSA-6791285 TP53 binds the BID gene promoter
R-HSA-6791302 TP53 binds the AIFM2 gene promoter
R-HSA-6791327 TP53 binds the BCL2L14 gene
R-HSA-6791349 TP53 binds the APAF1 gene promoter
R-HSA-6791387 TP53 binds the ARID3A gene
R-HSA-6796649 TP53 binds the CCNK gene
R-HSA-6797766 TP53 binds the BIRC5 gene
R-HSA-6797993 TP53 and CREBBP bind BNIP3L gene
R-HSA-6798020 TP53 binds the BTG2 gene
R-HSA-6798129 TP53 binds the CASP6 gene
R-HSA-6798138 TP53 binds the CASP10 gene
R-HSA-6798282 TP53 and E2F4 bind the CDC25C gene
R-HSA-6798304 TP53 binds the E2F7 gene
R-HSA-6798374 DYRK2 phosphorylates TP53
R-HSA-6799418 TP53 binds the TP53INP1 gene
R-HSA-6800042 TP53 binds the IGFBP3 gene
R-HSA-6800253 TP53 binds the BCL6 gene
R-HSA-6800279 TP53 binds the PIDD1 gene
R-HSA-6801087 TP53 binds the RABGGTA gene
R-HSA-6801166 TP53 binds the STEAP3 gene
R-HSA-6801209 TP53 binds the TRIAP1 gene
R-HSA-6801355 TP53 binds the NLRC4 gene
R-HSA-6801641 TP53 binds the PLK2 gene
R-HSA-6802165 TP53 binds the PLK3 gene
R-HSA-6803391 TP53 binds the PCBP4 gene
R-HSA-6803425 TP53 binds ZNF385A gene
R-HSA-6803719 TP53 binds ZNF385A
R-HSA-6803914 TP53 binds the RGCC gene
R-HSA-6803935 TP53 binds the PLAGL1 gene
R-HSA-6804191 TP53 binds the PRDM1 gene
R-HSA-6804242 TP53 binds the complex of JMY, EP300 and TTC5
R-HSA-6804402 TP53 binds POU4F1
R-HSA-6804425 TP53 binds POU4F2
R-HSA-6804441 RNF34 or RFFL ubiquitinates phosphorylated TP53
R-HSA-6805059 CK2:FACT phosphorylates TP53
R-HSA-6805620 KAT6A and PML bind TP53
R-HSA-6805730 SETD9 methylates TP53
R-HSA-6805740 SETD8 methylates TP53
R-HSA-6806408 TP53 binds the PMS2 gene
R-HSA-6806412 TP53 and AP-1 bind the MSH2 promoter
R-HSA-6806413 TP53 binds the MLH1 gene
R-HSA-6806417 TP53 binds the DDB2 gene
R-HSA-6806419 TP53 binds the FANCC gene
R-HSA-6811479 ING2 recruits EP300 to TP53
R-HSA-3222020 NUAK1 phosphorylates TP53
R-HSA-3222116 L3MBTL1 binds TP53 monomethylated on K382
R-HSA-3222259 PHF20 binds TP53 dimethylated on K370 and K382
R-HSA-6793685 Ubiquitinated TP53 translocates to the cytosol
R-HSA-8852337 GTSE1 binds TP53
R-HSA-6804879 MDM2 ubiquitinates TP53
R-HSA-6798615 TP53 binds the TP53AIP1 gene
R-HSA-6799409 HIPK2 phosphorylates TP53
R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
R-HSA-5690843 OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
R-HSA-6804998 p14-ARF forms a ternary complex with MDM2 and TP53
R-HSA-3222006 STK11 (LKB1) phosphorylates NUAK1
R-HSA-5632393 TP63/TP53 bind the DDIT4 gene promoter
R-HSA-5689950 USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
R-HSA-4647593 EP400 binds CDKN1A promoter
R-HSA-6811508 ING2-bound EP300 acetylates TP53
R-HSA-5628871 BRD7 promotes EP300-mediated acetylation of TP53
R-HSA-6805122 AURKB binds TP53
R-HSA-6803801 TP53 in complex with ZNF385A binds the CDKN1A promoter
R-HSA-6803858 TP53 binds the SFN gene
R-HSA-6804379 PRMT5 binds TTC5
R-HSA-6805638 KAT6A acetylates TP53
R-HSA-6798082 TP53 family members bind the CASP1 gene
R-HSA-6799761 TP53 binds PPP1R13L
R-HSA-6799777 TP53 family members bind PPP1R13B or TP53BP2
R-HSA-6800836 TP53 or TP63 binds the PERP gene
R-HSA-8852351 GTSE1 promotes translocation of TP53 to the cytosol
R-HSA-6804383 PRMT5 methylates TP53
R-HSA-6805126 AURKB phosphorylates TP53
R-HSA-6805650 MTA2-NuRD complex deacetylates TP53
R-HSA-3700981 TP53 family members bind the BAX promoter
R-HSA-4331340 TP53 binds the BBC3 (PUMA) promoter
R-HSA-6799462 TP53 family members bind the TP53I3 (PIG3) gene promoter
R-HSA-6799815 TP53 family members bind the FAS gene
R-HSA-3232118 SUMOylation of transcription factors
R-HSA-6804754 Regulation of TP53 Expression
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-69541 Stabilization of p53
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-6804760 Regulation of TP53 Activity through Methylation
R-HSA-8941855 RUNX3 regulates CDKN1A transcription
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-5689880 Ub-specific processing proteases
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-111448 Activation of NOXA and translocation to mitochondria
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21
R-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-69481 G2/M Checkpoints
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-109582 Hemostasis
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-2559583 Cellular Senescence
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-6807070 PTEN Regulation
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-5688426 Deubiquitination
R-HSA-449147 Signaling by Interleukins
R-HSA-2990846 SUMOylation
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-114452 Activation of BH3-only proteins
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
R-HSA-69560 Transcriptional activation of p53 responsive genes
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-69275 G2/M Transition
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-2262752 Cellular responses to stress
R-HSA-157118 Signaling by NOTCH
R-HSA-212436 Generic Transcription Pathway
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-597592 Post-translational protein modification
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-139915 Activation of PUMA and translocation to mitochondria
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-1640170 Cell Cycle
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-391251 Protein folding
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-162582 Signal Transduction
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-69615 G1/S DNA Damage Checkpoints
R-HSA-73894 DNA Repair
R-HSA-392499 Metabolism of proteins
R-HSA-168256 Immune System
R-HSA-109581 Apoptosis
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-74160 Gene expression (Transcription)
R-HSA-5357801 Programmed Cell Death

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001276696, NP_001263625, P04637-5, P53, uc010cni.1
UCSC ID: uc010cni.2
RefSeq Accession: NM_001276696
Protein: P04637-5, splice isoform of P04637 CCDS: CCDS45606.1, CCDS45605.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene TP53:
li-fraumeni (Li-Fraumeni Syndrome)
wilms-ov (Wilms Tumor Predisposition)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: yes RNA accession: NM_001276696.1
exon count: 12CDS single in 3' UTR: no RNA size: 2724
ORF size: 1026CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1780.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.