Description: Homo sapiens vesicle amine transport protein 1 homolog (T. californica) (VAT1), mRNA. RefSeq Summary (NM_006373): Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:41,166,622-41,172,228 Size: 5,607 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr17:41,168,078-41,170,801 Size: 2,724 Coding Exon Count: 5
ID:VAT1_HUMAN DESCRIPTION: RecName: Full=Synaptic vesicle membrane protein VAT-1 homolog; EC=1.-.-.-; FUNCTION: Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria (By similarity). TISSUE SPECIFICITY: Expressed in brain. Also expressed in glioblastoma cells. INDUCTION: Increased expression in glioblastomas and on wounding, in basal keratinocytes. This expression is calcium ion-dependent. SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. SEQUENCE CAUTION: Sequence=AAC37596.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99536
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.