Description: Homo sapiens C-type lectin domain family 4, member M (CLEC4M), transcript variant 1, mRNA. RefSeq Summary (NM_001144909): This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. [provided by RefSeq, May 2020]. Transcript (Including UTRs) Position: hg19 chr19:7,828,035-7,834,491 Size: 6,457 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr19:7,828,153-7,833,874 Size: 5,722 Coding Exon Count: 7
SARS infection Chan VS et al. 2006, Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection, Nature genetics. 2006 Jan;38(1):38-46.
[PubMed 16369534]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H2X3-8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK292278 - Homo sapiens cDNA FLJ77783 complete cds, highly similar to Homo sapiens CD209 antigen-like (CD209L), mRNA. BC038851 - Homo sapiens C-type lectin domain family 4, member M, mRNA (cDNA clone MGC:47866 IMAGE:5166966), complete cds. AF290887 - Homo sapiens L-SIGN mRNA, complete cds. AK314704 - Homo sapiens cDNA, FLJ95558. AK304499 - Homo sapiens cDNA FLJ52840 complete cds, highly similar to C-type lectin domain family 4 member M. JD231731 - Sequence 212755 from Patent EP1572962. JD206134 - Sequence 187158 from Patent EP1572962. AB015629 - Homo sapiens mRNA for type II membrane protein similar to HIV gp120-binding C-type lectin, complete cds, clone:HP01347. AF245219 - Homo sapiens probable mannose binding C-type lectin DC-SIGNR mRNA, complete cds. AK298084 - Homo sapiens cDNA FLJ55003 complete cds, highly similar to Homo sapiens C-type lectin domain family 4, member M (CLEC4M), transcript variant 6, mRNA. AK023750 - Homo sapiens cDNA FLJ13688 fis, clone PLACE2000062, highly similar to Homo sapiens mRNA for type II membrane protein. BC110614 - Homo sapiens C-type lectin domain family 4, member M, mRNA (cDNA clone MGC:129964 IMAGE:40032453), complete cds. KJ902090 - Synthetic construct Homo sapiens clone ccsbBroadEn_11484 CLEC4M gene, encodes complete protein. DQ893779 - Synthetic construct Homo sapiens clone IMAGE:100008239; FLH167490.01L; RZPDo839B0589D C-type lectin domain family 4, member M (CLEC4M) gene, encodes complete protein. KJ898195 - Synthetic construct Homo sapiens clone ccsbBroadEn_07589 CLEC4M gene, encodes complete protein. AY343913 - Homo sapiens L-SIGN variant (CD209L) mRNA, complete cds. AY042234 - Homo sapiens mDC-SIGN2 type I isoform (CD209L) mRNA, complete cds, alternatively spliced. AY042235 - Homo sapiens mDC-SIGN2 type III isoform (CD209L) mRNA, complete cds, alternatively spliced. AY042236 - Homo sapiens mDC-SIGN2 type IV isoform (CD209L) mRNA, complete cds, alternatively spliced. AY042237 - Homo sapiens mDC-SIGN2 type VI isoform (CD209L) mRNA, complete cds, alternatively spliced. AY042238 - Homo sapiens sDC-SIGN2 type I isoform (CD209L) mRNA, complete cds, alternatively spliced. AY042239 - Homo sapiens sDC-SIGN2 type II isoform (CD209L) mRNA, complete cds, alternatively spliced. AY042240 - Homo sapiens sDC-SIGN2 type III isoform (CD209L) mRNA, complete cds, alternatively spliced. JD555088 - Sequence 536112 from Patent EP1572962. JD462147 - Sequence 443171 from Patent EP1572962. JD094413 - Sequence 75437 from Patent EP1572962. JD249117 - Sequence 230141 from Patent EP1572962. JD276142 - Sequence 257166 from Patent EP1572962. JD251588 - Sequence 232612 from Patent EP1572962. JD249348 - Sequence 230372 from Patent EP1572962. JD535830 - Sequence 516854 from Patent EP1572962. JD111353 - Sequence 92377 from Patent EP1572962. JD516861 - Sequence 497885 from Patent EP1572962.