Human Gene ZNF414 (uc010dwf.3)
  Description: Homo sapiens zinc finger protein 414 (ZNF414), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:8,576,216-8,578,233 Size: 2,018 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr19:8,576,356-8,578,195 Size: 1,840 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:8,576,216-8,578,233)mRNA (may differ from genome)Protein (301 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN414_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 414;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.46 RPKM in Prostate
Total median expression: 467.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.8038-0.232 Picture PostScript Text
3' UTR -53.40140-0.381 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like

Pfam Domains:
PF15909 - C2H2-type zinc ribbon

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q96IQ9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF210783 - JP 2014500723-A/18286: Polycomb-Associated Non-Coding RNAs.
AK074191 - Homo sapiens cDNA FLJ23611 fis, clone ADKA02380.
AK225034 - Homo sapiens mRNA for zinc finger protein 414 variant, clone: adKA02380.
BC071937 - Homo sapiens zinc finger protein 414, mRNA (cDNA clone MGC:88624 IMAGE:5089259), complete cds.
BC007310 - Homo sapiens zinc finger protein 414, mRNA (cDNA clone MGC:15716 IMAGE:3353224), complete cds.
JD486087 - Sequence 467111 from Patent EP1572962.
JD269417 - Sequence 250441 from Patent EP1572962.
JD374175 - Sequence 355199 from Patent EP1572962.
KJ899789 - Synthetic construct Homo sapiens clone ccsbBroadEn_09183 ZNF414 gene, encodes complete protein.
EU446539 - Synthetic construct Homo sapiens clone IMAGE:100070330; IMAGE:100011748; FLH262806.01L zinc finger protein 414 (ZNF414) gene, encodes complete protein.
MA446360 - JP 2018138019-A/18286: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: EU446539, NM_032370, NP_115746, Q96IQ9, ZN414_HUMAN
UCSC ID: uc010dwf.3
RefSeq Accession: NM_032370
Protein: Q96IQ9 (aka ZN414_HUMAN)
CCDS: CCDS12205.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: EU446539.1
exon count: 5CDS single in 3' UTR: no RNA size: 979
ORF size: 906CDS single in intron: no Alignment % ID: 99.89
txCdsPredict score: 2012.00frame shift in genome: no % Coverage: 96.22
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 162# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.