Human Gene ZNF257 (uc010ecx.3)
  Description: Homo sapiens zinc finger protein 257 (ZNF257), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:22,235,266-22,273,903 Size: 38,638 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr19:22,235,435-22,272,244 Size: 36,810 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:22,235,266-22,273,903)mRNA (may differ from genome)Protein (563 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN257_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 257; AltName: Full=Bone marrow zinc finger 4; Short=BMZF-4;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF257
CDC HuGE Published Literature: ZNF257
Positive Disease Associations: Calcium , Cholesterol , Cholesterol, HDL , Cholesterol, LDL
Related Studies:
  1. Calcium
    , , . [PubMed 0]
  2. Cholesterol
    , , . [PubMed 0]
  3. Cholesterol
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.32 RPKM in Testis
Total median expression: 13.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -69.40169-0.411 Picture PostScript Text
3' UTR -357.081659-0.215 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9Y2Q1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC036446 - Homo sapiens zinc finger protein 257, mRNA (cDNA clone MGC:26419 IMAGE:4831021), complete cds.
AK056694 - Homo sapiens cDNA FLJ32132 fis, clone PEBLM2000270, highly similar to Zinc finger protein 257.
AF070651 - Homo sapiens tissue-type bone marrow zinc finger protein 4 mRNA, complete cds.
JD242199 - Sequence 223223 from Patent EP1572962.
JD368828 - Sequence 349852 from Patent EP1572962.
JD332110 - Sequence 313134 from Patent EP1572962.
JD098181 - Sequence 79205 from Patent EP1572962.
JD098182 - Sequence 79206 from Patent EP1572962.
EU446561 - Synthetic construct Homo sapiens clone IMAGE:100069849; IMAGE:100011770; FLH258616.01L zinc finger protein 257 (ZNF257) gene, encodes complete protein.
KJ903634 - Synthetic construct Homo sapiens clone ccsbBroadEn_13028 ZNF257 gene, encodes complete protein.
JD328851 - Sequence 309875 from Patent EP1572962.
BC020045 - Homo sapiens zinc finger protein 257, mRNA (cDNA clone IMAGE:3924140), with apparent retained intron.
JD330621 - Sequence 311645 from Patent EP1572962.
JD327922 - Sequence 308946 from Patent EP1572962.
JD327923 - Sequence 308947 from Patent EP1572962.
JD314898 - Sequence 295922 from Patent EP1572962.
JD314899 - Sequence 295923 from Patent EP1572962.
JD314900 - Sequence 295924 from Patent EP1572962.
JD368251 - Sequence 349275 from Patent EP1572962.
JD244408 - Sequence 225432 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y2Q1 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B3KPS4, BMZF4, E9PG34, NM_033468, NP_258429, Q8NE34, Q9Y2Q1, ZN257_HUMAN
UCSC ID: uc010ecx.3
RefSeq Accession: NM_033468
Protein: Q9Y2Q1 (aka ZN257_HUMAN or Z257_HUMAN)
CCDS: CCDS46030.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_033468.2
exon count: 4CDS single in 3' UTR: no RNA size: 3534
ORF size: 1692CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3584.00frame shift in genome: no % Coverage: 99.60
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.