Human Gene CEACAM5 (uc010ehz.1)
  Description: Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), mRNA.
RefSeq Summary (NM_004363): This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Transcript (Including UTRs)
   Position: hg19 chr19:42,212,530-42,219,789 Size: 7,260 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr19:42,212,651-42,219,413 Size: 6,763 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:42,212,530-42,219,789)mRNA (may differ from genome)Protein (315 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMalacardsMGIPubMedTreefam
Wikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CEACAM5
Diseases sorted by gene-association score: rectal neoplasm (11), colorectal cancer (10), lung cancer (9), gallbladder cancer (9), papillary adenocarcinoma (9), urachal cancer (8), pancreatic cancer (7), gastrointestinal carcinoma (6), urachal adenocarcinoma (6), cystadenocarcinoma (5), colon adenocarcinoma (5), gastric adenocarcinoma (5), ureter adenocarcinoma (5), immature teratoma of ovary (5), vaccinia (5), adamantinoid basal cell epithelioma (4), adamantinoma of long bones (4), stomach cancer (4), small cell cancer of the lung, somatic (4), mucoepidermoid carcinoma (4), medullary thyroid carcinoma, familial (3), hepatocellular carcinoma (3), colorectal adenocarcinoma (3), anal paget's disease (3), gallbladder lymphoma (3), lung cancer susceptibility 3 (3), prostate signet ring cell adenocarcinoma (3), cholangitis (3), mucoepidermoid esophageal carcinoma (3), anus adenocarcinoma (3), esophageal cancer (3), mesothelioma, somatic (3), cholangiocarcinoma, susceptibility to (2), apocrine adenoma (2), cutaneous mucoepidermoid carcinoma (2), sigmoid neoplasm (2), granulomatous endometritis (2), mucinous cystadenofibroma (2), female urethral cancer (2), gallbladder squamous cell carcinoma (2), breast cancer (2), bile duct cystadenocarcinoma (2), liver leiomyoma (2), warthin tumor (2), rectum adenocarcinoma (2), cell type cancer (2), gastrointestinal system cancer (2), cutaneous adenocystic carcinoma (2), liver lymphoma (2), ovarian cystadenocarcinoma (2), breast mucoepidermoid carcinoma (2), eccrine acrospiroma (2), tracheal cancer (2), vulval paget's disease (2), pancreatic serous cystadenoma (2), intracystic papillary adenoma (2), gastric cancer, somatic (2), vulva adenocarcinoma (2), fox-fordyce disease (2), epididymis cancer (2), epididymis adenocarcinoma (2), intracranial chondrosarcoma (2), ovary adenocarcinoma (2), ovary serous adenocarcinoma (2), nodular hidradenoma (2), anal gland adenocarcinoma (2), bile duct adenocarcinoma (2), cervix endometriosis (2), splenic tuberculosis (2), adenosquamous gallbladder carcinoma (2), descending colon cancer (2), ovarian cancer, somatic (2), microinvasive gastric cancer (2), thymus adenocarcinoma (2), adenoid basal cell carcinoma (2), ovary epithelial cancer (2), malignant ovarian surface epithelial-stromal neoplasm (2), gastrointestinal system benign neoplasm (2), endocrine gland cancer (2), cardiomyopathy, familial hypertrophic, 9 (2), mucinous adenofibroma (2), secretory meningioma (2), pericardial tuberculosis (1), melanotic medulloblastoma (1), rete testis adenocarcinoma (1), aggressive digital papillary adenocarcinoma (1), malignant spiradenoma (1), chondroid chordoma (1), intestinal benign neoplasm (1), clear cell adenoma (1), gastric small cell carcinoma (1), thyroid cancer, nonmedullary, 2 (1), cell type benign neoplasm (1), mucocele of salivary gland (1), lymphohistiocytoid mesothelioma (1), eccrine adenocarcinoma (1), organ system benign neoplasm (1), atypical follicular adenoma (1), pancreas adenocarcinoma (1), liver sarcoma (1), bile duct mucoepidermoid carcinoma (1), transverse colon cancer (1), integumentary system cancer (1), pancreatic mucinous cystadenoma (1), hematocele of tunica vaginalis testis (1), breast adenomyoepithelioma (1), breast myoepithelial neoplasm (1), female reproductive organ cancer (1), rete testis neoplasm (1), tuberculous empyema (1), epidermolysis bullosa, junctional, herlitz type (1), clear cell acanthoma (1), juvenile type testicular granulosa cell tumor (1), gastric signet ring cell adenocarcinoma (1), prostate squamous cell carcinoma (1), xanthogranulomatous cholecystitis (1), testicular granulosa cell tumor (1), melanoacanthoma (1), malignant epithelial mesothelioma (1), mucinous ovarian cystadenoma (1), biliary papillomatosis (1), ovarian lymphoma (1), ovarian mucinous neoplasm (1), colonic benign neoplasm (1), orbital cyst (1), mixed ductal-endocrine carcinoma (1), tolosa-hunt syndrome (1), acute thyroiditis (1), breast mucinous carcinoma (1), breast squamous cell carcinoma (1), meibomian cyst (1), tuberculous peritonitis (1), femoral neuropathy (1), congenital epulis (1), malignant biphasic mesothelioma (1), miliaria (1), urethral benign neoplasm (1), cervical clear cell adenocarcinoma (1), spermatocele (1), chondroid lipoma (1), infiltrative basal cell carcinoma (1), extragonadal seminoma (1), superior mesenteric artery syndrome (1), holoprosencephaly 1 (1), testicular yolk sac tumor (1), pancreatic cystadenocarcinoma (1), cystitis cystica (1), cloacogenic carcinoma (1), breast metaplastic carcinoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 347.48 RPKM in Colon - Transverse
Total median expression: 607.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.55121-0.244 Picture PostScript Text
3' UTR -104.95376-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  JD147700 - Sequence 128724 from Patent EP1572962.
M29540 - Human carcinoembryonic antigen mRNA (CEA), complete cds.
JD515355 - Sequence 496379 from Patent EP1572962.
AK310844 - Homo sapiens cDNA, FLJ17886.
BC034671 - Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 5, mRNA (cDNA clone MGC:34212 IMAGE:5184800), complete cds.
AK223101 - Homo sapiens mRNA for carcinoembryonic antigen-related cell adhesion molecule 5 variant, clone: KAT04486.
JD071438 - Sequence 52462 from Patent EP1572962.
JD153999 - Sequence 135023 from Patent EP1572962.
JD164612 - Sequence 145636 from Patent EP1572962.
CR749337 - Homo sapiens mRNA; cDNA DKFZp781M2392 (from clone DKFZp781M2392).
JD340028 - Sequence 321052 from Patent EP1572962.
DQ896753 - Synthetic construct Homo sapiens clone IMAGE:100011213; FLH166370.01L; RZPDo839G0185D carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) gene, encodes complete protein.
DQ890840 - Synthetic construct clone IMAGE:100003470; FLH166374.01X; RZPDo839G0186D carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) gene, encodes complete protein.
CU689928 - Synthetic construct Homo sapiens gateway clone IMAGE:100020345 5' read CEACAM5 mRNA.
KJ905171 - Synthetic construct Homo sapiens clone ccsbBroadEn_14581 CEACAM5 gene, encodes complete protein.
AB852566 - Homo sapiens CEACAM5 mRNA for carcinoembryonic antigen-related cell adhesion molecule 5 isoform 5D, complete cds.
AB852567 - Homo sapiens CEACAM5 mRNA for carcinoembryonic antigen-related cell adhesion molecule 5 isoform 3D, complete cds.
X16455 - Human mRNA for carcinoembryonic antigen pCEA80-11.
M15042 - Human carcinoembryonic antigen mRNA.
E01630 - cDNA encoding human carcinoembryonic antigen.
LF366910 - JP 2014500723-A/174413: Polycomb-Associated Non-Coding RNAs.
MA602487 - JP 2018138019-A/174413: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK310844
UCSC ID: uc010ehz.1
RefSeq Accession: NM_004363

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK310844.1
exon count: 3CDS single in 3' UTR: no RNA size: 1430
ORF size: 948CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2096.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 621# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.