Human Gene DEDD2 (uc031rkw.1)
  Description: Homo sapiens death effector domain containing 2 (DEDD2), transcript variant 9, non-coding RNA.
RefSeq Summary (NM_133328): This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].
Transcript (Including UTRs)
   Position: hg19 chr19:42,702,745-42,721,944 Size: 19,200 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr19:42,703,590-42,706,192 Size: 2,603 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:42,702,745-42,721,944)mRNA (may differ from genome)Protein (147 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIOMIMPubMed
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 54.21 RPKM in Whole Blood
Total median expression: 577.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -188.16454-0.414 Picture PostScript Text
3' UTR -305.54845-0.362 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AY125488 - Homo sapiens death effector domain-containing DNA-binding 2 protein (DEDD2) mRNA, complete cds.
BC013372 - Homo sapiens death effector domain containing 2, mRNA (cDNA clone MGC:16414 IMAGE:3941907), complete cds.
AK130203 - Homo sapiens cDNA FLJ26693 fis, clone MPG07953.
BC027930 - Homo sapiens death effector domain containing 2, mRNA (cDNA clone MGC:35529 IMAGE:5199772), complete cds.
AK075328 - Homo sapiens cDNA PSEC0004 fis, clone NT2RM1000558, moderately similar to Death effector domain-containing DNA binding protein 2.
JD344968 - Sequence 325992 from Patent EP1572962.
JD075967 - Sequence 56991 from Patent EP1572962.
JD512324 - Sequence 493348 from Patent EP1572962.
JD334693 - Sequence 315717 from Patent EP1572962.
JD104074 - Sequence 85098 from Patent EP1572962.
JD383323 - Sequence 364347 from Patent EP1572962.
JD477389 - Sequence 458413 from Patent EP1572962.
JD271112 - Sequence 252136 from Patent EP1572962.
JD050420 - Sequence 31444 from Patent EP1572962.
JD160693 - Sequence 141717 from Patent EP1572962.
JD045396 - Sequence 26420 from Patent EP1572962.
JD217206 - Sequence 198230 from Patent EP1572962.
AF443591 - Homo sapiens death effector domain-containing DNA-binding protein 2 (DEDD2) mRNA, complete cds.
AF457575 - Homo sapiens death effector domain-containing protein FLAME-3 (FLAME-3) mRNA, complete cds.
KJ895728 - Synthetic construct Homo sapiens clone ccsbBroadEn_05122 DEDD2 gene, encodes complete protein.
AB463562 - Synthetic construct DNA, clone: pF1KB7639, Homo sapiens DEDD2 gene for death effector domain containing 2, without stop codon, in Flexi system.
AK307895 - Homo sapiens cDNA, FLJ97843.
KJ906445 - Synthetic construct Homo sapiens clone ccsbBroadEn_16115 DEDD2 gene, encodes complete protein.
JD057180 - Sequence 38204 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_133328, NP_579874, NR_073051, uc010eid.3
UCSC ID: uc031rkw.1
RefSeq Accession: NM_133328

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_073051.1
exon count: 5CDS single in 3' UTR: no RNA size: 1743
ORF size: 444CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 633.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.