Description: Homo sapiens sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 3, mRNA. RefSeq Summary (NM_198846): This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]. Transcript (Including UTRs) Position: hg19 chr19:52,032,644-52,035,110 Size: 2,467 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr19:52,032,898-52,034,869 Size: 1,972 Coding Exon Count: 5
ID:SIGL6_HUMAN DESCRIPTION: RecName: Full=Sialic acid-binding Ig-like lectin 6; Short=Siglec-6; AltName: Full=CD33 antigen-like 1; AltName: Full=CDw327; AltName: Full=Obesity-binding protein 1; Short=OB-BP1; AltName: CD_antigen=CD327; Flags: Precursor; FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SUBUNIT: Interacts with LEP. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted. TISSUE SPECIFICITY: Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. SIMILARITY: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SEQUENCE CAUTION: Sequence=AAB70702.1; Type=Erroneous initiation; Sequence=AAH35359.2; Type=Erroneous initiation; Sequence=AAI40799.1; Type=Erroneous initiation; Sequence=BAA24983.1; Type=Erroneous initiation; Sequence=BAA24984.1; Type=Erroneous initiation; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Siglec-6; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_273";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43699
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
US Server
