Description: Homo sapiens WD repeat domain 35 (WDR35), transcript variant 2, mRNA. RefSeq Summary (NM_020779): This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]. Transcript (Including UTRs) Position: hg19 chr2:20,110,029-20,189,884 Size: 79,856 Total Exon Count: 27 Strand: -
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AB037757 - Homo sapiens KIAA1336 mRNA for KIAA1336 protein. BC036659 - Homo sapiens WD repeat domain 35, mRNA (cDNA clone MGC:33196 IMAGE:5266940), complete cds. AK122917 - Homo sapiens cDNA FLJ16596 fis, clone TESTI4005635, highly similar to WD repeat protein 35. AK315094 - Homo sapiens cDNA, FLJ96052. AB385451 - Synthetic construct DNA, clone: pF1KA1336, Homo sapiens WDR35 gene for WD repeat protein 35, complete cds, without stop codon, in Flexi system. BC033951 - Homo sapiens WD repeat domain 35, mRNA (cDNA clone IMAGE:5286529). AK022866 - Homo sapiens cDNA FLJ12804 fis, clone NT2RP2002219. JD303406 - Sequence 284430 from Patent EP1572962. JD500848 - Sequence 481872 from Patent EP1572962. JD073535 - Sequence 54559 from Patent EP1572962. JD193207 - Sequence 174231 from Patent EP1572962. AK091205 - Homo sapiens cDNA FLJ33886 fis, clone CTONG2007399, highly similar to WD repeat protein 35. AX746847 - Sequence 372 from Patent EP1308459. JD501446 - Sequence 482470 from Patent EP1572962. JD226218 - Sequence 207242 from Patent EP1572962. JD148512 - Sequence 129536 from Patent EP1572962. AL832903 - Homo sapiens mRNA; cDNA DKFZp762F1313 (from clone DKFZp762F1313).