Description: Homo sapiens regenerating islet-derived 1 beta (REG1B), mRNA. RefSeq Summary (NM_006507): This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr2:79,312,666-79,315,150 Size: 2,485 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr2:79,313,451-79,314,738 Size: 1,288 Coding Exon Count: 3
ID:REG1B_HUMAN DESCRIPTION: RecName: Full=Lithostathine-1-beta; AltName: Full=Pancreatic stone protein 2; Short=PSP-2; AltName: Full=Regenerating islet-derived protein 1-beta; Short=REG-1-beta; AltName: Full=Regenerating protein I beta; Flags: Precursor; FUNCTION: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration. SUBCELLULAR LOCATION: Secreted. PTM: All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc tetrasaccharide core and get elongated (microheterogeneity). SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Lithostathine A; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_255";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48304
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
