Description: Homo sapiens inositol polyphosphate-4-phosphatase, type I, 107kDa (INPP4A), transcript variant a, mRNA. RefSeq Summary (NM_004027): This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]. Transcript (Including UTRs) Position: hg19 chr2:99,061,321-99,207,496 Size: 146,176 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr2:99,136,512-99,204,071 Size: 67,560 Coding Exon Count: 9
ID:B8ZZB2_HUMAN DESCRIPTION: SubName: Full=Type I inositol 3,4-bisphosphate 4-phosphatase; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): INPP4A CDC HuGE Published Literature: INPP4A Positive Disease Associations: Asthma| Related Studies:
Asthma| Angela J Rogers , et al. American journal of respiratory and critical care medicine 2009 179(12):1084-90, Assessing the reproducibility of asthma candidate gene associations, using genome-wide data., American journal of respiratory and critical care medicine 2009 179(12):1084-90.
[PubMed 19264973]
We replicated asthma associations for a minority of candidate genes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on B8ZZB2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
