Human Gene STAT1 (uc010fse.2)
  Description: Homo sapiens signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant alpha, mRNA.
RefSeq Summary (NM_007315): The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020].
Transcript (Including UTRs)
   Position: hg19 chr2:191,833,762-191,878,681 Size: 44,920 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr2:191,835,429-191,874,729 Size: 39,301 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:191,833,762-191,878,681)mRNA (may differ from genome)Protein (750 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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MGIneXtProtOMIMPubMedReactomeTreefam
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: STAT1_HUMAN
DESCRIPTION: RecName: Full=Signal transducer and activator of transcription 1-alpha/beta; AltName: Full=Transcription factor ISGF-3 components p91/p84;
FUNCTION: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
SUBUNIT: Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation. Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation. Interacts with NMI. Interacts with Sendai virus C', C, Y1 and Y2 proteins, Nipah virus P, V and W proteins, and rabies virus phosphoprotein preventing activation of ISRE and GAS promoter (By similarity). Interacts with HCV core protein; the interaction results in STAT1 degradation. Interacts with PIAS1; the interaction requires phosphorylation on Ser-727 and inhibits STAT1 activation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with PIAS1 (dimethylated on arginine); the interaction results in release of STAT1 from its target gene. Interacts with SRC (By similarity). Interacts with ERBB4 (phosphorylated). Interacts with PTK2/FAK1.
INTERACTION: Q16531:DDB1; NbExp=2; IntAct=EBI-1057697, EBI-350322; Q01094:E2F1; NbExp=2; IntAct=EBI-1057697, EBI-448924; Q7Z434:MAVS; NbExp=3; IntAct=EBI-1057697, EBI-995373; P19793:RXRA; NbExp=2; IntAct=EBI-1057697, EBI-78598; P52630:STAT2; NbExp=4; IntAct=EBI-1057697, EBI-1546963;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4.
PTM: Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including IFN-alpha, IFN- gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2. PHosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation, regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PKCdelta induces apoptosis in response to DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase.
PTM: Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727, and by interaction with PIAS proteins. Enhances the transactivation activity.
PTM: ISGylated.
DISEASE: Defects in STAT1 are the cause of STAT1 deficiency complete (STAT1D) [MIM:613796]. STAT1D is a disorder characterized by susceptibility to severe mycobacterial and viral infections. Affected individuals can develop disseminated infections and die of viral illness.
DISEASE: Defects in STAT1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
DISEASE: Defects in STAT1 are the cause of familial candidiasis type 7 (CANDF7) [MIM:614162]. A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Note=STAT1 mutations in patients with autosomal dominant candidiasis lead to defective responses of type 1 and type 17 helper T-cells, characterized by reduced production of interferon-alpha, interleukin-17, and interleukin-22. These cytokines are crucial for the antifungal defense of skin and mucosa (PubMed:21714643).
SIMILARITY: Belongs to the transcription factor STAT family.
SIMILARITY: Contains 1 SH2 domain.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/stat1/";
WEB RESOURCE: Name=STAT1base; Note=STAT1 mutation db; URL="http://bioinf.uta.fi/STAT1base/";
WEB RESOURCE: Name=Wikipedia; Note=STAT1 entry; URL="http://en.wikipedia.org/wiki/STAT1";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): STAT1
CDC HuGE Published Literature: STAT1

-  MalaCards Disease Associations
  MalaCards Gene Search: STAT1
Diseases sorted by gene-association score: immunodeficiency 31c, autosomal dominant* (1550), immunodeficiency 31a, mycobacteriosis, autosomal dominant* (1550), immunodeficiency 31b, mycobacterial and viral infections, autosomal recessive* (1550), familial atypical mycobacteriosis, stat1-related* (100), mumps (24), rabies (18), candidiasis (16), thanatophoric dysplasia, type i (14), tuberculosis (13), human t-cell leukemia virus type 2 (13), fanconi anemia, complementation group c (10), thanatophoric dysplasia, type ii (10), hepatitis c (10), chronic mucocutaneous candidiasis (10), measles (9), coccidioidomycosis (9), infectious anterior uveitis (9), zika fever (8), progressive multifocal leukoencephalopathy (8), venezuelan equine encephalitis (8), campylobacteriosis (8), mouth disease (8), chronic inflammatory demyelinating polyradiculoneuropathy (7), dengue hemorrhagic fever (7), salmonellosis (6), testicular leukemia (6), ulceroglandular tularemia (6), skin squamous cell carcinoma (6), microphthalmia with limb anomalies (6), acute myocarditis (6), severe acute respiratory syndrome (6), polyradiculoneuropathy (5), japanese encephalitis (5), cd3gamma deficiency (5), norwegian scabies (5), opportunistic mycosis (5), central nervous system tuberculosis (5), yellow fever (5), inflammatory bowel disease (5), erythrocytosis, somatic (4), hepatitis b (4), breast cancer (3), uv-sensitive syndrome (3), viral infectious disease (2), chronic lymphocytic leukemia (2), colorectal cancer (1), leukemia, acute promyelocytic, somatic (1), fanconi anemia, complementation group a (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 222.49 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1033.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -155.10432-0.359 Picture PostScript Text
3' UTR -418.031667-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR008967 - p53-like_TF_DNA-bd
IPR000980 - SH2
IPR022752 - STAT1_TAZ2-bd_C
IPR013800 - STAT_TF_alpha
IPR015988 - STAT_TF_coiled-coil
IPR001217 - STAT_TF_core
IPR013801 - STAT_TF_DNA-bd
IPR012345 - STAT_TF_DNA-bd_sub
IPR013799 - STAT_TF_prot_interaction

Pfam Domains:
PF00017 - SH2 domain
PF01017 - STAT protein, all-alpha domain
PF02864 - STAT protein, DNA binding domain
PF02865 - STAT protein, protein interaction domain
PF12162 - STAT1 TAZ2 binding domain

SCOP Domains:
47655 - STAT
48092 - Transcription factor STAT-4 N-domain
49417 - p53-like transcription factors
55550 - SH2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1BF5 - X-ray MuPIT 1YVL - X-ray MuPIT 2KA6 - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P42224
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0031730 CCR5 chemokine receptor binding
GO:0035035 histone acetyltransferase binding
GO:0035257 nuclear hormone receptor binding
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0045296 cadherin binding
GO:0051721 protein phosphatase 2A binding
GO:0070491 repressing transcription factor binding
GO:1990841 promoter-specific chromatin binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002230 positive regulation of defense response to virus by host
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007259 JAK-STAT cascade
GO:0007584 response to nutrient
GO:0008015 blood circulation
GO:0008284 positive regulation of cell proliferation
GO:0009612 response to mechanical stimulus
GO:0010742 macrophage derived foam cell differentiation
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0032727 positive regulation of interferon-alpha production
GO:0032869 cellular response to insulin stimulus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034097 response to cytokine
GO:0035456 response to interferon-beta
GO:0035458 cellular response to interferon-beta
GO:0038114 interleukin-21-mediated signaling pathway
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042981 regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043434 response to peptide hormone
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046725 negative regulation by virus of viral protein levels in host cell
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051591 response to cAMP
GO:0051607 defense response to virus
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0061326 renal tubule development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway
GO:0071345 cellular response to cytokine stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071407 cellular response to organic cyclic compound
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0043542 endothelial cell migration

Cellular Component:
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030424 axon
GO:0030425 dendrite
GO:0032991 macromolecular complex
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  M97935 - Homo sapiens transcription factor ISGF-3 mRNA, complete cds.
FW340019 - Screening.
HH934437 - Sequence 105 from Patent WO2010111471.
HV964655 - JP 2012521763-A/105: RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA).
JD375865 - Sequence 356889 from Patent EP1572962.
CR749636 - Homo sapiens mRNA; cDNA DKFZp686B04100 (from clone DKFZp686B04100).
JD510221 - Sequence 491245 from Patent EP1572962.
JD262584 - Sequence 243608 from Patent EP1572962.
JD239130 - Sequence 220154 from Patent EP1572962.
JD506375 - Sequence 487399 from Patent EP1572962.
JD092726 - Sequence 73750 from Patent EP1572962.
JD303155 - Sequence 284179 from Patent EP1572962.
JD499323 - Sequence 480347 from Patent EP1572962.
JD290876 - Sequence 271900 from Patent EP1572962.
JD530712 - Sequence 511736 from Patent EP1572962.
JD502597 - Sequence 483621 from Patent EP1572962.
JD515760 - Sequence 496784 from Patent EP1572962.
JD262933 - Sequence 243957 from Patent EP1572962.
AK292604 - Homo sapiens cDNA FLJ78299 complete cds, highly similar to Homo sapiens signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant alpha, mRNA.
JD492789 - Sequence 473813 from Patent EP1572962.
JD090801 - Sequence 71825 from Patent EP1572962.
JD284633 - Sequence 265657 from Patent EP1572962.
JD521945 - Sequence 502969 from Patent EP1572962.
JD419056 - Sequence 400080 from Patent EP1572962.
JD113601 - Sequence 94625 from Patent EP1572962.
JD499157 - Sequence 480181 from Patent EP1572962.
JD528096 - Sequence 509120 from Patent EP1572962.
JD153556 - Sequence 134580 from Patent EP1572962.
GU211347 - Homo sapiens signal transducer and activator of transcription 1 (STAT1) mRNA, complete cds.
GU211348 - Homo sapiens truncated signal transducer and activator of transcription 1 (STAT1) mRNA, complete cds, alternatively spliced.
AK315002 - Homo sapiens cDNA, FLJ95929, Homo sapiens signal transducer and activator of transcription 1,91kDa (STAT1), transcript variant alpha, mRNA.
AB384835 - Synthetic construct DNA, clone: pF1KB3682, Homo sapiens STAT1 gene for signal transducer and activator of transcription 1-alpha/beta, complete cds, without stop codon, in Flexi system.
M97936 - Human transcription factor ISGF-3 mRNA sequence.
AK225853 - Homo sapiens mRNA for signal transducer and activator of transcription 1 isoform alpha variant, clone: FCC125G04.
BC002704 - Homo sapiens signal transducer and activator of transcription 1, 91kDa, mRNA (cDNA clone MGC:3493 IMAGE:3627218), complete cds.
AK096686 - Homo sapiens cDNA FLJ39367 fis, clone PEBLM2006709, highly similar to SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA.
BT007241 - Homo sapiens signal transducer and activator of transcription 1, 91kDa mRNA, complete cds.
KJ892213 - Synthetic construct Homo sapiens clone ccsbBroadEn_01607 STAT1 gene, encodes complete protein.
KR709939 - Synthetic construct Homo sapiens clone CCSBHm_00007942 STAT1 (STAT1) mRNA, encodes complete protein.
KR709940 - Synthetic construct Homo sapiens clone CCSBHm_00007943 STAT1 (STAT1) mRNA, encodes complete protein.
KR709941 - Synthetic construct Homo sapiens clone CCSBHm_00007944 STAT1 (STAT1) mRNA, encodes complete protein.
KR709942 - Synthetic construct Homo sapiens clone CCSBHm_00007945 STAT1 (STAT1) mRNA, encodes complete protein.
EU831980 - Synthetic construct Homo sapiens clone HAIB:100067009; DKFZo008G0923 signal transducer and activator of transcription 1, 91kDa protein (STAT1) gene, encodes complete protein.
EU832073 - Synthetic construct Homo sapiens clone HAIB:100067102; DKFZo004G0924 signal transducer and activator of transcription 1, 91kDa protein (STAT1) gene, encodes complete protein.
CU678136 - Synthetic construct Homo sapiens gateway clone IMAGE:100017777 5' read STAT1 mRNA.
BC141921 - Homo sapiens cDNA clone IMAGE:40131546, partial cds.
JD482869 - Sequence 463893 from Patent EP1572962.
JD475964 - Sequence 456988 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04062 - Chemokine signaling pathway
hsa04620 - Toll-like receptor signaling pathway
hsa04630 - Jak-STAT signaling pathway
hsa05140 - Leishmaniasis
hsa05200 - Pathways in cancer
hsa05212 - Pancreatic cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec
h_ifnaPathway - IFN alpha signaling pathway
h_p38mapkPathway - p38 MAPK Signaling Pathway
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_chemicalPathway - Apoptotic Signaling in Response to DNA Damage
h_il22bppathway - IL22 Soluble Receptor Signaling Pathway
h_TPOPathway - TPO Signaling Pathway
h_egfPathway - EGF Signaling Pathway
h_mapkPathway - MAPKinase Signaling Pathway
h_pdgfPathway - PDGF Signaling Pathway
h_ifngPathway - IFN gamma signaling pathway
h_il10Pathway - IL-10 Anti-inflammatory Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P42224 (Reactome details) participates in the following event(s):

R-HSA-873921 Binding of STAT1 to p-IFNGR1
R-HSA-909718 Formation of p-STAT1 homodimer
R-HSA-997326 Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP
R-HSA-873922 Phosphorylation of STAT1 by JAK kinases
R-HSA-909726 Phosphorylation of STAT1
R-HSA-913529 Translocation of p-STAT1:p-STAT1 dimer to nucleus
R-HSA-877281 PIAS1 binds p-STAT1 dimer
R-HSA-1031713 GAF binds the GAS promoter elements in the IFNG-regulated genes
R-HSA-873917 Translocation of STAT1 dimer to nucleus
R-HSA-873927 Release of STAT1 dimer from active receptor unit
R-HSA-909552 Phosphorylation of STAT1 at Ser727
R-HSA-909725 Interaction of IRF9 with p-STAT2:p-STAT1
R-HSA-909722 Release of p-STAT2:p-STAT1 dimer
R-HSA-1470010 Dimerization of STATs
R-HSA-1470012 Disassociation and translocation of STATs to the nucleus
R-HSA-909721 Translocation of ISGF3 complex to nucleus
R-HSA-1015699 ISGF3 binds the ISRE promoter elements in IFN-stimulated genes
R-HSA-997309 Dephosphorylation of STAT1 by SHP2
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-877312 Regulation of IFNG signaling
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1059683 Interleukin-6 signaling
R-HSA-168256 Immune System
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-6783589 Interleukin-6 family signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-162582 Signal Transduction
R-HSA-449147 Signaling by Interleukins
R-HSA-909726 Phosphorylation of STAT1
R-HSA-909725 Interaction of IRF9 with p-STAT2:p-STAT1
R-HSA-909722 Release of p-STAT2:p-STAT1 dimer
R-HSA-1015699 ISGF3 binds the ISRE promoter elements in IFN-stimulated genes
R-HSA-909721 Translocation of ISGF3 complex to nucleus
R-HSA-997309 Dephosphorylation of STAT1 by SHP2
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-912694 Regulation of IFNA signaling
R-HSA-168256 Immune System
R-HSA-9008015 RUNX2 binds STAT1
R-HSA-8950782 p-STAT1 binds p-STAT3
R-HSA-380782 STAT binds to the active receptor
R-HSA-1112565 Tyrosine phosphorylated IL6ST binds STAT1,STAT3
R-HSA-1168768 JAK2 binds STAT1/3
R-HSA-1169406 ISGylation of host proteins
R-HSA-1433456 Recruitment of STATs
R-HSA-1888198 FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
R-HSA-6788571 STAT1,STAT3,STAT6 bind IL13:IL13R type II
R-HSA-1112538 Phosphorylated STAT1, STAT3 form dimers
R-HSA-1112604 Phosphorylated STATs are released
R-HSA-9021325 NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter
R-HSA-9021334 STAT1 binds HEY1 gene promoter
R-HSA-1112602 Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
R-HSA-1168767 JAK2 phosphorylates STAT1/STAT3
R-HSA-6788582 STAT1,STAT3,STAT6 phosphorylation
R-HSA-9020956 Interleukin-27 signaling
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-186763 Downstream signal transduction
R-HSA-1059683 Interleukin-6 signaling
R-HSA-982772 Growth hormone receptor signaling
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-447115 Interleukin-12 family signaling
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-449147 Signaling by Interleukins
R-HSA-186797 Signaling by PDGF
R-HSA-6783589 Interleukin-6 family signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1839124 FGFR1 mutant receptor activation
R-HSA-451927 Interleukin-2 family signaling
R-HSA-212436 Generic Transcription Pathway
R-HSA-9012852 Signaling by NOTCH3
R-HSA-168256 Immune System
R-HSA-913531 Interferon Signaling
R-HSA-162582 Signal Transduction
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-157118 Signaling by NOTCH
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-74160 Gene expression (Transcription)
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A8K989, AK292604, B2RCA0, D2KFR8, D3DPI7, NM_007315, NP_009330, P42224, Q53S88, Q53XW4, Q68D00, Q9UDL5, STAT1_HUMAN
UCSC ID: uc010fse.2
RefSeq Accession: NM_007315
Protein: P42224 (aka STAT1_HUMAN or STA1_HUMAN)
CCDS: CCDS2309.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK292604.1
exon count: 24CDS single in 3' UTR: no RNA size: 3097
ORF size: 2253CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 4625.00frame shift in genome: no % Coverage: 99.90
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 277# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.