Description: Homo sapiens CASP8 and FADD-like apoptosis regulator (CFLAR), transcript variant 5, mRNA. RefSeq Summary (NM_001127184): The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]. Transcript (Including UTRs) Position: hg19 chr2:201,994,452-202,037,411 Size: 42,960 Total Exon Count: 7 Strand: +
Press "+" in the title bar above to open this section.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK296036 - Homo sapiens cDNA FLJ58399 complete cds, highly similar to CASP8 and FADD-like apoptosis regulator precursor. AK297387 - Homo sapiens cDNA FLJ56698 complete cds, highly similar to CASP8 and FADD-like apoptosis regulator precursor. Y14040 - Homo sapiens mRNA for CASH beta protein. Y14039 - Homo sapiens mRNA for CASH alpha protein. AF005774 - Homo sapiens caspase-like apoptosis regulatory protein (clarp) mRNA, alternatively spliced, complete cds. AF009616 - Homo sapiens FLAME-1 mRNA, complete cds. AF010127 - Homo sapiens Casper mRNA, complete cds. U97074 - Homo sapiens FLICE-like inhibitory protein long form mRNA, complete cds. AK315924 - Homo sapiens cDNA, FLJ78823 complete cds, highly similar to CASP8 and FADD-like apoptosis regulator precursor. BC001602 - Homo sapiens CASP8 and FADD-like apoptosis regulator, mRNA (cDNA clone MGC:2044 IMAGE:3542993), complete cds. KR422625 - Homo sapiens cell line Caki-2 usurpin-beta splice variant (CFLAR) mRNA, complete cds, alternatively spliced. AB209600 - Homo sapiens mRNA for CASP8 and FADD-like apoptosis regulator variant protein. AF015450 - Homo sapiens Usurpin-alpha mRNA, complete cds. AK308767 - Homo sapiens cDNA, FLJ98808. AK289913 - Homo sapiens cDNA FLJ78499 complete cds, highly similar to Homo sapiens CASP8 and FADD-like apoptosis regulator, mRNA. AK315208 - Homo sapiens cDNA, FLJ96198, highly similar to Homo sapiens CASP8 and FADD-like apoptosis regulator (CFLAR), mRNA. U97075 - Homo sapiens FLICE-like inhibitory protein short form mRNA, complete cds. LF206105 - JP 2014500723-A/13608: Polycomb-Associated Non-Coding RNAs. JD174531 - Sequence 155555 from Patent EP1572962. JD400195 - Sequence 381219 from Patent EP1572962. LF351463 - JP 2014500723-A/158966: Polycomb-Associated Non-Coding RNAs. AF041458 - Homo sapiens I-FLICE mRNA, complete cds. HM005351 - Homo sapiens clone HTL-T-38 testis secretory sperm-binding protein Li 233m mRNA, complete cds. AF005775 - Homo sapiens caspase-like apoptosis regulatory protein 2 (clarp) mRNA, alternatively spliced, complete cds. AF015452 - Homo sapiens Usurpin-gamma mRNA, complete cds. CU674780 - Synthetic construct Homo sapiens gateway clone IMAGE:100020300 5' read CFLAR mRNA. AF015451 - Homo sapiens Usurpin-beta mRNA, complete cds. AF041460 - Homo sapiens I-FLICE isoform 3 mRNA, complete cds. AB590361 - Synthetic construct DNA, clone: pFN21AE1312, Homo sapiens CFLAR gene for CASP8 and FADD-like apoptosis regulator, without stop codon, in Flexi system. DQ893760 - Synthetic construct Homo sapiens clone IMAGE:100008220; FLH164286.01L; RZPDo839E09161D CASP8 and FADD-like apoptosis regulator (CFLAR) gene, encodes complete protein. BT006751 - Homo sapiens CASP8 and FADD-like apoptosis regulator mRNA, complete cds. DQ890592 - Synthetic construct clone IMAGE:100003222; FLH164290.01X; RZPDo839E09162D CASP8 and FADD-like apoptosis regulator (CFLAR) gene, encodes complete protein. KJ892636 - Synthetic construct Homo sapiens clone ccsbBroadEn_02030 CFLAR gene, encodes complete protein. AF009617 - Homo sapiens FLAME-1-beta mRNA, alternatively spliced, complete cds. AF009618 - Homo sapiens FLAME-1-gamma mRNA, alternatively spliced, complete cds. AF009619 - Homo sapiens FLAME-1-delta mRNA, alternatively spliced, complete cds. U85059 - Human protease MRIT-alpha-1 mRNA, complete cds. AX751991 - Sequence 1 from Patent WO03035868. AF041461 - Homo sapiens I-FLICE isoform 4 mRNA, complete cds. LF351462 - JP 2014500723-A/158965: Polycomb-Associated Non-Coding RNAs. LF351461 - JP 2014500723-A/158964: Polycomb-Associated Non-Coding RNAs. JD025931 - Sequence 6955 from Patent EP1572962. JD022408 - Sequence 3432 from Patent EP1572962. AK304585 - Homo sapiens cDNA FLJ59611 complete cds, highly similar to CASP8 and FADD-like apoptosis regulator precursor. JD033854 - Sequence 14878 from Patent EP1572962. AF041462 - Homo sapiens I-FLICE isoform 5 mRNA, complete cds. JD032568 - Sequence 13592 from Patent EP1572962. JD030588 - Sequence 11612 from Patent EP1572962. LF351460 - JP 2014500723-A/158963: Polycomb-Associated Non-Coding RNAs. AF041459 - Homo sapiens I-FLICE isoform 2 mRNA, complete cds. AX751993 - Sequence 3 from Patent WO03035868. CQ967473 - Sequence 15 from Patent EP1486564. JD084122 - Sequence 65146 from Patent EP1572962. JD101874 - Sequence 82898 from Patent EP1572962. JD167622 - Sequence 148646 from Patent EP1572962. JD481204 - Sequence 462228 from Patent EP1572962. JD361809 - Sequence 342833 from Patent EP1572962. JD158876 - Sequence 139900 from Patent EP1572962. JD266512 - Sequence 247536 from Patent EP1572962. JD344084 - Sequence 325108 from Patent EP1572962. JD178710 - Sequence 159734 from Patent EP1572962. JD300548 - Sequence 281572 from Patent EP1572962. JD411728 - Sequence 392752 from Patent EP1572962. JD056621 - Sequence 37645 from Patent EP1572962. JD137547 - Sequence 118571 from Patent EP1572962. JD313680 - Sequence 294704 from Patent EP1572962. JD349074 - Sequence 330098 from Patent EP1572962. JD380262 - Sequence 361286 from Patent EP1572962. JD277702 - Sequence 258726 from Patent EP1572962. JD345682 - Sequence 326706 from Patent EP1572962. JD225366 - Sequence 206390 from Patent EP1572962. JD072331 - Sequence 53355 from Patent EP1572962. JD296881 - Sequence 277905 from Patent EP1572962. JD311393 - Sequence 292417 from Patent EP1572962. JD311395 - Sequence 292419 from Patent EP1572962. JD311394 - Sequence 292418 from Patent EP1572962. JD527363 - Sequence 508387 from Patent EP1572962. DQ598355 - Homo sapiens piRNA piR-36421, complete sequence. JD031260 - Sequence 12284 from Patent EP1572962. JD085749 - Sequence 66773 from Patent EP1572962. JD306515 - Sequence 287539 from Patent EP1572962. JD067605 - Sequence 48629 from Patent EP1572962. JD067606 - Sequence 48630 from Patent EP1572962. DQ589339 - Homo sapiens piRNA piR-56451, complete sequence. DQ577359 - Homo sapiens piRNA piR-45471, complete sequence. JD211431 - Sequence 192455 from Patent EP1572962. DQ577392 - Homo sapiens piRNA piR-45504, complete sequence. JD471987 - Sequence 453011 from Patent EP1572962. DQ580663 - Homo sapiens piRNA piR-48775, complete sequence. DQ580661 - Homo sapiens piRNA piR-48773, complete sequence. DQ580662 - Homo sapiens piRNA piR-48774, complete sequence. DQ598327 - Homo sapiens piRNA piR-36393, complete sequence. JD488689 - Sequence 469713 from Patent EP1572962. JD302268 - Sequence 283292 from Patent EP1572962. AK125394 - Homo sapiens cDNA FLJ43404 fis, clone OCBBF2017516. AK124664 - Homo sapiens cDNA FLJ42673 fis, clone BRAMY2028856. AL365413 - Homo sapiens EST from clone 223524, 5' end. JD501855 - Sequence 482879 from Patent EP1572962. MA587040 - JP 2018138019-A/158966: Polycomb-Associated Non-Coding RNAs. MA587039 - JP 2018138019-A/158965: Polycomb-Associated Non-Coding RNAs. MA587038 - JP 2018138019-A/158964: Polycomb-Associated Non-Coding RNAs. MA587037 - JP 2018138019-A/158963: Polycomb-Associated Non-Coding RNAs. MA441682 - JP 2018138019-A/13608: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04210 - Apoptosis hsa05142 - Chagas disease
BioCarta from NCI Cancer Genome Anatomy Project h_fasPathway - FAS signaling pathway ( CD95 ) h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation