Human Gene FER1L4 (uc010gfg.1)
  Description: RecName: Full=Fer-1-like protein 4;
Transcript (Including UTRs)
   Position: hg19 chr20:34,151,622-34,173,198 Size: 21,577 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr20:34,152,630-34,173,165 Size: 20,536 Coding Exon Count: 16 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:34,151,622-34,173,198)mRNA (may differ from genome)Protein (714 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldEnsembl
ExonPrimerGeneCardsH-INVHGNCLynxMGI
PubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FER1L4
CDC HuGE Published Literature: FER1L4
Positive Disease Associations: Cholesterol
Related Studies:
  1. Cholesterol
    Tanya M Teslovich et al. Nature 2010, Biological, clinical and population relevance of 95 loci for blood lipids., Nature. [PubMed 20686565]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.06 RPKM in Bladder
Total median expression: 106.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.6033-0.230 Picture PostScript Text
3' UTR -362.531008-0.360 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00168 - C2 domain
PF08150 - FerB (NUC096) domain

SCOP Domains:
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)

ModBase Predicted Comparative 3D Structure on A9Z1Z3-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AF218030 - Homo sapiens clone PP79 unknown mRNA.
AL833764 - Homo sapiens mRNA; cDNA DKFZp666J207 (from clone DKFZp666J207).
AF218012 - Homo sapiens clone PP3795 unknown mRNA.
AK023521 - Homo sapiens cDNA FLJ13459 fis, clone PLACE1003366, weakly similar to Homo sapiens otoferlin (OTOF) mRNA.
BX648024 - Homo sapiens mRNA; cDNA DKFZp686F01207 (from clone DKFZp686F01207).
AY461812 - Homo sapiens FER-1-like protein 4 (FER1L4) mRNA, complete cds.
JD289124 - Sequence 270148 from Patent EP1572962.
JD136043 - Sequence 117067 from Patent EP1572962.
JD264974 - Sequence 245998 from Patent EP1572962.
JD420521 - Sequence 401545 from Patent EP1572962.
JD387819 - Sequence 368843 from Patent EP1572962.
JD084300 - Sequence 65324 from Patent EP1572962.
JD132057 - Sequence 113081 from Patent EP1572962.
JD374355 - Sequence 355379 from Patent EP1572962.
JD506298 - Sequence 487322 from Patent EP1572962.
JD392445 - Sequence 373469 from Patent EP1572962.
JD342362 - Sequence 323386 from Patent EP1572962.
JD547039 - Sequence 528063 from Patent EP1572962.
JD264260 - Sequence 245284 from Patent EP1572962.
JD275972 - Sequence 256996 from Patent EP1572962.
JD345674 - Sequence 326698 from Patent EP1572962.
JD353175 - Sequence 334199 from Patent EP1572962.
JD353173 - Sequence 334197 from Patent EP1572962.
JD274869 - Sequence 255893 from Patent EP1572962.
JD228580 - Sequence 209604 from Patent EP1572962.
JD300172 - Sequence 281196 from Patent EP1572962.
JD080287 - Sequence 61311 from Patent EP1572962.
JD359411 - Sequence 340435 from Patent EP1572962.
JD563801 - Sequence 544825 from Patent EP1572962.
JD345674 - Sequence 326698 from Patent EP1572962.
JD407811 - Sequence 388835 from Patent EP1572962.
JD258881 - Sequence 239905 from Patent EP1572962.
JD353175 - Sequence 334199 from Patent EP1572962.
JD152394 - Sequence 133418 from Patent EP1572962.
JD353173 - Sequence 334197 from Patent EP1572962.
JD274869 - Sequence 255893 from Patent EP1572962.
JD541250 - Sequence 522274 from Patent EP1572962.
JD434305 - Sequence 415329 from Patent EP1572962.
JD052099 - Sequence 33123 from Patent EP1572962.
JD415348 - Sequence 396372 from Patent EP1572962.
JD483828 - Sequence 464852 from Patent EP1572962.
JD301173 - Sequence 282197 from Patent EP1572962.
JD490261 - Sequence 471285 from Patent EP1572962.
JD436528 - Sequence 417552 from Patent EP1572962.
JD387135 - Sequence 368159 from Patent EP1572962.
JD465878 - Sequence 446902 from Patent EP1572962.
JD075813 - Sequence 56837 from Patent EP1572962.
JD044927 - Sequence 25951 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A9Z1Z3-3, AY461812, C20orf124
UCSC ID: uc010gfg.1
Representative RNA: AY461812
Protein: A9Z1Z3-3, splice isoform of A9Z1Z3

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AY461812.1
exon count: 16CDS single in 3' UTR: no RNA size: 6168
ORF size: 2145CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 4383.00frame shift in genome: no % Coverage: 37.76
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.