Description: Homo sapiens adenosine A2a receptor (ADORA2A), mRNA. RefSeq Summary (NM_000675): This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]. Transcript (Including UTRs) Position: hg19 chr22:24,828,087-24,838,325 Size: 10,239 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr22:24,829,373-24,837,457 Size: 8,085 Coding Exon Count: 2
ID:AA2AR_HUMAN DESCRIPTION: RecName: Full=Adenosine receptor A2a; FUNCTION: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. SUBUNIT: Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4. INTERACTION: P30542:ADORA1; NbExp=4; IntAct=EBI-2902702, EBI-2903663; P62158:CALM3; NbExp=3; IntAct=EBI-2902702, EBI-397435; Q99418:CYTH2; NbExp=6; IntAct=EBI-2902702, EBI-448974; P14416:DRD2; NbExp=2; IntAct=EBI-2902702, EBI-2928178; P31424-1:Grm5 (xeno); NbExp=3; IntAct=EBI-2902702, EBI-2902778; Q7Z6G3:NECAB2; NbExp=5; IntAct=EBI-2902702, EBI-950070; Q13107:USP4; NbExp=4; IntAct=EBI-2902702, EBI-723290; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. DOMAIN: The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface. PTM: Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. SEQUENCE CAUTION: Sequence=AAA58356.1; Type=Erroneous initiation;
anxiety disorder Alsene, K. et al. 2003, Association between A2a receptor gene polymorphisms and caffeine-induced anxiety., Neuropsychopharmacology. 2003 Sep;28(9):1694-702.
[PubMed 12825092]
The study shows that an adenosine receptor gene polymorphism that has been associated with Panic Disorder is also associated with anxiogenic responses to an acute dose of caffeine.
caffeine consumption Cornelis, M. C. et al. 2007, Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption, Am J Clin Nutr 2007 86(1) 240-4.
[PubMed 17616786]
Our findings show that the probability of having the ADORA2A 1083TT genotype decreases as habitual caffeine consumption increases.
caffeine-induced anxiety. Alsene K 2003, Association between A2a receptor gene polymorphisms and caffeine-induced anxiety., Neuropsychopharmacology. 2003 Sep;28(9):1694-702.
[PubMed 12825092]
The study shows that an adenosine receptor gene polymorphism that has been associated with Panic Disorder is also associated with anxiogenic responses to an acute dose of caffeine.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P29274
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
