Description: Homo sapiens ceramide kinase (CERK), mRNA. RefSeq Summary (NM_022766): CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Transcript (Including UTRs) Position: hg19 chr22:47,080,307-47,108,190 Size: 27,884 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr22:47,083,031-47,103,860 Size: 20,830 Coding Exon Count: 8
ID:CERK1_HUMAN DESCRIPTION: RecName: Full=Ceramide kinase; Short=hCERK; EC=2.7.1.138; AltName: Full=Acylsphingosine kinase; AltName: Full=Lipid kinase 4; Short=LK4; FUNCTION: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. CATALYTIC ACTIVITY: ATP + ceramide = ADP + ceramide 1-phosphate. COFACTOR: Calcium. COFACTOR: Magnesium. ENZYME REGULATION: Inhibited by sulfatide. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6.0-7.5; SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. TISSUE SPECIFICITY: High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung. SIMILARITY: Contains 1 DAGKc domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TCT0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.