Human Gene MYRIP (uc010hhv.3)
Description: Homo sapiens myosin VIIA and Rab interacting protein (MYRIP), mRNA.
Transcript (Including UTRs)
Position: hg19 chr3:39,851,303-40,301,811 Size: 450,509 Total Exon Count: 16 Strand: +
Coding Region
Position: hg19 chr3:39,942,308-40,299,657 Size: 357,350 Coding Exon Count: 15
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MYRIP
CDC HuGE Published Literature: MYRIP
Positive Disease Associations: Body Composition
, Body Mass Index
, Echocardiography
, Natriuretic Peptide, Brain
, Neurobehavioral Manifestations
, Sleep
, sleep duration
Related Studies: Body Composition , , .
[PubMed 0 ]
Body Composition , , .
[PubMed 0 ]
Body Composition , , .
[PubMed 0 ]
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MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF02318 - FYVE-type zinc finger
PF04698 - Rab effector MyRIP/melanophilin C-terminus
SCOP Domains: 57903 - FYVE/PHD zinc finger
ModBase Predicted Comparative 3D Structure on Q8NFW9-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AK312412 - Homo sapiens cDNA, FLJ92749.BC092512 - Homo sapiens myosin VIIA and Rab interacting protein, mRNA (cDNA clone MGC:104940 IMAGE:3093499), complete cds.AK126013 - Homo sapiens cDNA FLJ44025 fis, clone TESTI4026700, highly similar to Rab effector MyRIP.AF396687 - Homo sapiens rab effector MYRIP (MYRIP) mRNA, complete cds.BC109311 - Homo sapiens myosin VIIA and Rab interacting protein, mRNA (cDNA clone MGC:130034 IMAGE:40036096), complete cds.BC109312 - Homo sapiens myosin VIIA and Rab interacting protein, mRNA (cDNA clone MGC:130035 IMAGE:40036097), complete cds.AK310972 - Homo sapiens cDNA, FLJ18014.AB083783 - Homo sapiens slac2-c mRNA for Slp homologue lacking C2 domains-c, complete cds.KJ905446 - Synthetic construct Homo sapiens clone ccsbBroadEn_15029 MYRIP gene, encodes complete protein.AK125334 - Homo sapiens cDNA FLJ43344 fis, clone NT2RI3008162, highly similar to Rab effector MyRIP.AK316068 - Homo sapiens cDNA, FLJ78967 complete cds, highly similar to Rab effector MyRIP.AK294714 - Homo sapiens cDNA FLJ56979 complete cds, highly similar to Rab effector MyRIP.JD345037 - Sequence 326061 from Patent EP1572962.AL050090 - Homo sapiens mRNA; cDNA DKFZp586F1018 (from clone DKFZp586F1018).JD244100 - Sequence 225124 from Patent EP1572962.JD099701 - Sequence 80725 from Patent EP1572962.JD248171 - Sequence 229195 from Patent EP1572962.JD052206 - Sequence 33230 from Patent EP1572962.JD313425 - Sequence 294449 from Patent EP1572962.JD465910 - Sequence 446934 from Patent EP1572962.JD158182 - Sequence 139206 from Patent EP1572962.JD445561 - Sequence 426585 from Patent EP1572962.JD205872 - Sequence 186896 from Patent EP1572962.JD067336 - Sequence 48360 from Patent EP1572962.JD362597 - Sequence 343621 from Patent EP1572962.JD311015 - Sequence 292039 from Patent EP1572962.JD278573 - Sequence 259597 from Patent EP1572962.JD218610 - Sequence 199634 from Patent EP1572962.JD453983 - Sequence 435007 from Patent EP1572962.JD351610 - Sequence 332634 from Patent EP1572962.JD355030 - Sequence 336054 from Patent EP1572962.JD258057 - Sequence 239081 from Patent EP1572962.JD467645 - Sequence 448669 from Patent EP1572962.JD074448 - Sequence 55472 from Patent EP1572962.JD281897 - Sequence 262921 from Patent EP1572962.JD046208 - Sequence 27232 from Patent EP1572962.JD092195 - Sequence 73219 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: AK126013, NM_015460, NP_056275, Q8NFW9-2, SLAC2CUCSC ID: uc010hhv.3RefSeq Accession: NM_015460
Protein: Q8NFW9-2 , splice isoform of Q8NFW9
CCDS: CCDS68390.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AK126013.1
exon count:
16 CDS single in 3' UTR:
no
RNA size:
2981
ORF size:
2385 CDS single in intron:
no
Alignment % ID:
99.83
txCdsPredict score:
4935.50 frame shift in genome:
no
% Coverage:
96.44
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.