Description: Homo sapiens NCK interacting protein with SH3 domain (NCKIPSD), transcript variant 1, mRNA. RefSeq Summary (NM_016453): The protein encoded by this gene contains a nuclear localization signal. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation This protein is involved in the formation and maintenance of dendritic spines, and modulates synaptic activity in neurons. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2019]. Transcript (Including UTRs) Position: hg19 chr3:48,718,626-48,723,334 Size: 4,709 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr3:48,718,627-48,723,240 Size: 4,614 Coding Exon Count: 5
ID:C9JSC3_HUMAN DESCRIPTION: SubName: Full=NCK-interacting protein with SH3 domain; Flags: Fragment; SIMILARITY: Contains 1 SH3 domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on C9JSC3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
