Human Gene TMPRSS7 (uc010hqb.2)
  Description: Homo sapiens transmembrane protease, serine 7 (TMPRSS7), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:111,758,465-111,800,116 Size: 41,652 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr3:111,760,805-111,799,931 Size: 39,127 Coding Exon Count: 15 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:111,758,465-111,800,116)mRNA (may differ from genome)Protein (717 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.90 RPKM in Testis
Total median expression: 1.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.20170-0.319 Picture PostScript Text
3' UTR -59.30185-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00057 - Low-density lipoprotein receptor domain class A
PF00089 - Trypsin
PF00431 - CUB domain
PF01390 - SEA domain

SCOP Domains:
49854 - Spermadhesin, CUB domain
50494 - Trypsin-like serine proteases
82671 - SEA domain
57424 - LDL receptor-like module

ModBase Predicted Comparative 3D Structure on Q7RTY8-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  KJ904213 - Synthetic construct Homo sapiens clone ccsbBroadEn_13607 TMPRSS7 gene, encodes complete protein.
HQ258472 - Synthetic construct Homo sapiens clone IMAGE:100072901 Unknown protein gene, encodes complete protein.
AK131211 - Homo sapiens cDNA FLJ16088 fis, clone NT2RP7008435, weakly similar to EPITHIN (EC 3.4.21.-).
BC117322 - Homo sapiens transmembrane protease, serine 7, mRNA (cDNA clone MGC:150931 IMAGE:40125873), complete cds.
JD307234 - Sequence 288258 from Patent EP1572962.
JD323198 - Sequence 304222 from Patent EP1572962.
JD353559 - Sequence 334583 from Patent EP1572962.
JD088173 - Sequence 69197 from Patent EP1572962.
JD550730 - Sequence 531754 from Patent EP1572962.
JD184978 - Sequence 166002 from Patent EP1572962.
JD501766 - Sequence 482790 from Patent EP1572962.
JD361035 - Sequence 342059 from Patent EP1572962.
JD141433 - Sequence 122457 from Patent EP1572962.
JD172981 - Sequence 154005 from Patent EP1572962.
JD539750 - Sequence 520774 from Patent EP1572962.
JD511031 - Sequence 492055 from Patent EP1572962.
JD259220 - Sequence 240244 from Patent EP1572962.
JD349535 - Sequence 330559 from Patent EP1572962.
JD063536 - Sequence 44560 from Patent EP1572962.
JD372608 - Sequence 353632 from Patent EP1572962.
JD301599 - Sequence 282623 from Patent EP1572962.
JD233703 - Sequence 214727 from Patent EP1572962.
JD245836 - Sequence 226860 from Patent EP1572962.
JD378613 - Sequence 359637 from Patent EP1572962.
JD052949 - Sequence 33973 from Patent EP1572962.
JD300164 - Sequence 281188 from Patent EP1572962.
JD104726 - Sequence 85750 from Patent EP1572962.
JD427350 - Sequence 408374 from Patent EP1572962.
JD499746 - Sequence 480770 from Patent EP1572962.
JD371016 - Sequence 352040 from Patent EP1572962.
JD368086 - Sequence 349110 from Patent EP1572962.
JD060824 - Sequence 41848 from Patent EP1572962.
JD483926 - Sequence 464950 from Patent EP1572962.
JD231319 - Sequence 212343 from Patent EP1572962.
JD482163 - Sequence 463187 from Patent EP1572962.
JD060501 - Sequence 41525 from Patent EP1572962.
JD275574 - Sequence 256598 from Patent EP1572962.
JD552002 - Sequence 533026 from Patent EP1572962.
JD486961 - Sequence 467985 from Patent EP1572962.
JD491801 - Sequence 472825 from Patent EP1572962.
JD512689 - Sequence 493713 from Patent EP1572962.
JD071235 - Sequence 52259 from Patent EP1572962.
JD446351 - Sequence 427375 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001042575, NP_001036040, Q7RTY8-2
UCSC ID: uc010hqb.2
RefSeq Accession: NM_001042575
Protein: Q7RTY8-2, splice isoform of Q7RTY8 CCDS: CCDS43129.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001042575.2
exon count: 16CDS single in 3' UTR: no RNA size: 2509
ORF size: 2154CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4356.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.