Description: Homo sapiens CD80 molecule (CD80), mRNA. RefSeq Summary (NM_005191): The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr3:119,246,580-119,276,775 Size: 30,196 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr3:119,246,618-119,276,575 Size: 29,958 Coding Exon Count: 4
Celiac Disease| G Trynka , et al. Gut 2009 58(8):1078-83, Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling., Gut 2009 58(8):1078-83.
[PubMed 19240061]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5DTB0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC042665 - Homo sapiens CD80 molecule, mRNA (cDNA clone MGC:34467 IMAGE:5181343), complete cds. AK292129 - Homo sapiens cDNA FLJ75225 complete cds, highly similar to Homo sapiens CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) (CD80), mRNA. M27533 - Human Ig rearranged B7 protein mRNA VC1-region, complete cds. AY197777 - Homo sapiens costimulatory factor CD80 type 1 mRNA, complete cds; alternatively spliced. AY197778 - Homo sapiens costimulatory factor CD80 type 2 mRNA, complete cds; alternatively spliced. KJ890861 - Synthetic construct Homo sapiens clone ccsbBroadEn_00255 CD80 gene, encodes complete protein. AB590671 - Synthetic construct DNA, clone: pFN21AE1779, Homo sapiens CD80 gene for CD80 molecule, without stop codon, in Flexi system. AY081815 - Homo sapiens costimulatory molecule variant IgV-CD80 (CD80) mRNA, complete cds, alternatively spliced. JD544794 - Sequence 525818 from Patent EP1572962. JD099884 - Sequence 80908 from Patent EP1572962. JD195205 - Sequence 176229 from Patent EP1572962. JD248995 - Sequence 230019 from Patent EP1572962. JD274360 - Sequence 255384 from Patent EP1572962. JD153520 - Sequence 134544 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04514 - Cell adhesion molecules (CAMs) hsa04620 - Toll-like receptor signaling pathway hsa04672 - Intestinal immune network for IgA production hsa04940 - Type I diabetes mellitus hsa05320 - Autoimmune thyroid disease hsa05322 - Systemic lupus erythematosus hsa05330 - Allograft rejection hsa05332 - Graft-versus-host disease hsa05416 - Viral myocarditis
BioCarta from NCI Cancer Genome Anatomy Project h_asbcellPathway - Antigen Dependent B Cell Activation h_blymphocytePathway - B Lymphocyte Cell Surface Molecules h_ctla4Pathway - The Co-Stimulatory Signal During T-cell Activation