Description: Homo sapiens monoglyceride lipase (MGLL), transcript variant 2, mRNA. RefSeq Summary (NM_001256585): This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]. Transcript (Including UTRs) Position: hg19 chr3:127,434,317-127,542,093 Size: 107,777 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr3:127,434,465-127,540,661 Size: 106,197 Coding Exon Count: 5
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MGLL CDC HuGE Published Literature: MGLL Positive Disease Associations: C-Reactive Protein
, Hemoglobins Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99685
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006954 inflammatory response GO:0009966 regulation of signal transduction GO:0016042 lipid catabolic process GO:0019369 arachidonic acid metabolic process GO:0019433 triglyceride catabolic process GO:0036155 acylglycerol acyl-chain remodeling GO:0046464 acylglycerol catabolic process GO:0050727 regulation of inflammatory response GO:0051930 regulation of sensory perception of pain GO:2000124 regulation of endocannabinoid signaling pathway