Human Gene ASTE1 (uc010htm.1)
  Description: Homo sapiens asteroid homolog 1 (Drosophila) (ASTE1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:130,732,721-130,745,636 Size: 12,916 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr3:130,732,901-130,744,150 Size: 11,250 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:130,732,721-130,745,636)mRNA (may differ from genome)Protein (704 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIPubMed
UniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.82 RPKM in Testis
Total median expression: 126.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.40207-0.210 Picture PostScript Text
3' UTR -27.50180-0.153 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026832 - Asteroid
IPR006085 - XPG_DNA_repair_N

Pfam Domains:
PF00752 - XPG N-terminal domain
PF12813 - XPG domain containing

SCOP Domains:
88723 - PIN domain-like

ModBase Predicted Comparative 3D Structure on D6RG30
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004518 nuclease activity

Biological Process:
GO:0006281 DNA repair
GO:0090305 nucleic acid phosphodiester bond hydrolysis


-  Descriptions from all associated GenBank mRNAs
  AF113539 - Homo sapiens hypothalamus protein HT001 mRNA, complete cds.
AK027258 - Homo sapiens cDNA: FLJ23605 fis, clone LNG15982, highly similar to AF113539 Homo sapiens hypothalamus protein HT001 mRNA.
BC069265 - Homo sapiens asteroid homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:6427121).
BC103709 - Homo sapiens asteroid homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:6008729), partial cds.
JD245494 - Sequence 226518 from Patent EP1572962.
BC110616 - Homo sapiens asteroid homolog 1 (Drosophila), mRNA (cDNA clone MGC:129980 IMAGE:40033986), complete cds.
AK294156 - Homo sapiens cDNA FLJ52104 complete cds.
BC030274 - Homo sapiens asteroid homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:3920927), partial cds.
KJ902497 - Synthetic construct Homo sapiens clone ccsbBroadEn_11891 ASTE1 gene, encodes complete protein.
KJ898705 - Synthetic construct Homo sapiens clone ccsbBroadEn_08099 ASTE1 gene, encodes complete protein.
AK301388 - Homo sapiens cDNA FLJ60917 complete cds.
AK027806 - Homo sapiens cDNA FLJ14900 fis, clone PLACE1005176, highly similar to Homo sapiens hypothalamus protein HT001 mRNA.
JD467529 - Sequence 448553 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC069265, D6RG30, D6RG30_HUMAN, hCG_15790, NM_014065, NP_054784
UCSC ID: uc010htm.1
RefSeq Accession: NM_014065
Protein: D6RG30 CCDS: CCDS3068.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC069265.1
exon count: 7CDS single in 3' UTR: no RNA size: 2530
ORF size: 2115CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4390.00frame shift in genome: no % Coverage: 98.89
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.