Human Gene TMEM14E (uc010hvo.3)
  Description: Homo sapiens transmembrane protein 14E (TMEM14E), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:152,057,487-152,058,779 Size: 1,293 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr3:152,058,316-152,058,693 Size: 378 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:152,057,487-152,058,779)mRNA (may differ from genome)Protein (125 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGeneCardsHGNCLynxMGI
neXtProtPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TM14E_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 14E;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the UPF0136 (TMEM14) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.15 RPKM in Whole Blood
Total median expression: 3.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.8086-0.300 Picture PostScript Text
3' UTR -199.99829-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005349 - UPF0136_TM

Pfam Domains:
PF03647 - Transmembrane proteins 14C

ModBase Predicted Comparative 3D Structure on Q6UXP3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY358260 - Homo sapiens clone DNA176661 QMDP9344 (UNQ9344) mRNA, complete cds.
JD385717 - Sequence 366741 from Patent EP1572962.
JD156223 - Sequence 137247 from Patent EP1572962.
JD367655 - Sequence 348679 from Patent EP1572962.
JD156224 - Sequence 137248 from Patent EP1572962.
JD367656 - Sequence 348680 from Patent EP1572962.
JD413817 - Sequence 394841 from Patent EP1572962.
JD535480 - Sequence 516504 from Patent EP1572962.
JD367652 - Sequence 348676 from Patent EP1572962.
JD566813 - Sequence 547837 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001123228, NP_001116700, Q6UXP3, TM14E_HUMAN, UNQ9344/PRO34067
UCSC ID: uc010hvo.3
RefSeq Accession: NM_001123228
Protein: Q6UXP3 (aka TM14E_HUMAN)
CCDS: CCDS43161.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001123228.1
exon count: 1CDS single in 3' UTR: no RNA size: 1293
ORF size: 378CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 864.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.