Description: Homo sapiens F-box protein 45 (FBXO45), mRNA. RefSeq Summary (NM_001105573): Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Transcript (Including UTRs) Position: hg19 chr3:196,295,725-196,315,930 Size: 20,206 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr3:196,295,856-196,311,189 Size: 15,334 Coding Exon Count: 3
ID:FBSP1_HUMAN DESCRIPTION: RecName: Full=F-box/SPRY domain-containing protein 1; AltName: Full=F-box only protein 45; Short=hFbxo45; FUNCTION: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Forms a complex with MYCBP2 and SKP1 but does not appear to form an authentic SCF (SKP1-CUL1-F-box protein) complex (By similarity). Interacts (via B30.2/SPRY domain) with TP73 (via SAM domain); leading to TP73 ubiquitination and degradation by proteasome. Interacts (via SRY domain) with UNC13A; leading to degradation of UNC13A by the proteasome (By similarity). SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). INDUCTION: Down-regulated in response to DNA-damage. SIMILARITY: Belongs to the FBXO45/Fsn family. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 F-box domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P0C2W1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.